CUTC — 40 ClinVar variants
All ClinVar germline CUTC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
1 Likely benign · 39 Uncertain significance
Full CUTC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CUTC p.Ala13Pro Uncertain significance Single submitter
- CUTC p.Ala46Asp Uncertain significance Single submitter
- CUTC p.Arg104His Uncertain significance Single submitter
- CUTC p.Arg146Gln Uncertain significance Single submitter
- CUTC p.Arg168Cys Uncertain significance Single submitter
- CUTC p.Arg48Pro Uncertain significance Single submitter
- CUTC p.Arg83Gln Uncertain significance Single submitter
- CUTC p.Arg83Trp Uncertain significance Single submitter
- CUTC p.Asn24Lys Uncertain significance Single submitter
- CUTC p.Asp149Glu Uncertain significance Single submitter
- CUTC p.Cys31Phe Uncertain significance Single submitter
- CUTC p.Cys52Tyr Uncertain significance Single submitter
- CUTC p.Gly202Asp Uncertain significance Single submitter
- CUTC p.Gly58Arg Uncertain significance Single submitter
- CUTC p.Ile185Thr Uncertain significance Single submitter
- CUTC p.Ile196Thr Uncertain significance Single submitter
- CUTC p.Lys234Arg Uncertain significance Single submitter
- CUTC p.Met99Thr Uncertain significance Single submitter
- CUTC p.Met99Val Uncertain significance Single submitter
- CUTC p.Ser231Leu Uncertain significance Single submitter
- CUTC p.Ser249Pro Uncertain significance Single submitter
- CUTC p.Val169Met Uncertain significance Single submitter
- CUTC p.Val261Ala Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CUTC p.Ala268Thr Uncertain significance Single submitter
- CUTC p.Arg104Cys Uncertain significance Single submitter
- CUTC p.Arg12Gly Uncertain significance Single submitter
- CUTC p.Arg226Trp Uncertain significance Single submitter
- CUTC p.Asp126Asn Uncertain significance Single submitter
- CUTC p.Asp33Glu Uncertain significance Single submitter
- CUTC p.Cys223Gly Uncertain significance Single submitter
- CUTC p.Gly194Asp Uncertain significance Single submitter
- CUTC p.His124Tyr Uncertain significance Single submitter
- CUTC p.Ile196Val Uncertain significance Single submitter
- CUTC p.Ile271Asn Uncertain significance Single submitter
- CUTC p.Ile271Met Uncertain significance Single submitter
- CUTC p.Leu213Phe Uncertain significance Single submitter
- CUTC p.Lys260Gln Likely benign Single submitter
- CUTC p.Met28Val Uncertain significance Single submitter
- CUTC p.Ser252Phe Uncertain significance Single submitter
- CUTC p.Tyr109Cys Uncertain significance Single submitter
All CUTC variants
Likely benign 1
- p.Lys260Gln Single submitter ⚠
Uncertain significance 39
- p.Ala13Pro Single submitter ⚠
- p.Ala268Thr Single submitter ⚠
- p.Ala46Asp Single submitter ⚠
- p.Arg104Cys Single submitter ⚠
- p.Arg104His Single submitter ⚠
- p.Arg12Gly Single submitter ⚠
- p.Arg146Gln Single submitter ⚠
- p.Arg168Cys Single submitter ⚠
- p.Arg226Trp Single submitter ⚠
- p.Arg48Pro Single submitter ⚠
- p.Arg83Gln Single submitter ⚠
- p.Arg83Trp Single submitter ⚠
- p.Asn24Lys Single submitter ⚠
- p.Asp126Asn Single submitter ⚠
- p.Asp149Glu Single submitter ⚠
- p.Asp33Glu Single submitter ⚠
- p.Cys223Gly Single submitter ⚠
- p.Cys31Phe Single submitter ⚠
- p.Cys52Tyr Single submitter ⚠
- p.Gly194Asp Single submitter ⚠
- p.Gly202Asp Single submitter ⚠
- p.Gly58Arg Single submitter ⚠
- p.His124Tyr Single submitter ⚠
- p.Ile185Thr Single submitter ⚠
- p.Ile196Thr Single submitter ⚠
- p.Ile196Val Single submitter ⚠
- p.Ile271Asn Single submitter ⚠
- p.Ile271Met Single submitter ⚠
- p.Leu213Phe Single submitter ⚠
- p.Lys234Arg Single submitter ⚠
- p.Met28Val Single submitter ⚠
- p.Met99Thr Single submitter ⚠
- p.Met99Val Single submitter ⚠
- p.Ser231Leu Single submitter ⚠
- p.Ser249Pro Single submitter ⚠
- p.Ser252Phe Single submitter ⚠
- p.Tyr109Cys Single submitter ⚠
- p.Val169Met Single submitter ⚠
- p.Val261Ala Single submitter ⚠