CWC22 — 131 ClinVar variants
All ClinVar germline CWC22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 120 flagged for review →
4 Benign · 7 Likely benign · 120 Uncertain significance
Full CWC22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 120
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CWC22 p.Ala419Thr Uncertain significance Single submitter
- CWC22 p.Ala674Ser Uncertain significance Single submitter
- CWC22 p.Arg156Lys Uncertain significance Single submitter
- CWC22 p.Arg236Thr Uncertain significance Single submitter
- CWC22 p.Arg246Gly Uncertain significance Single submitter
- CWC22 p.Arg318His Uncertain significance Single submitter
- CWC22 p.Arg320Gln Uncertain significance Single submitter
- CWC22 p.Arg343Trp Uncertain significance Single submitter
- CWC22 p.Arg456His Uncertain significance Single submitter
- CWC22 p.Arg457His Uncertain significance Single submitter
- CWC22 p.Arg644Gln Uncertain significance Single submitter
- CWC22 p.Arg823Ser Uncertain significance Single submitter
- CWC22 p.Arg870Gly Uncertain significance Single submitter
- CWC22 p.Asn223Ser Uncertain significance Single submitter
- CWC22 p.Asn70His Uncertain significance Single submitter
- CWC22 p.Asn873Ser Uncertain significance Single submitter
- CWC22 p.Asp15Asn Uncertain significance Single submitter
- CWC22 p.Asp388Tyr Uncertain significance Single submitter
- CWC22 p.Asp436Glu Uncertain significance Single submitter
- CWC22 p.Asp769Asn Uncertain significance Single submitter
- CWC22 p.Asp818His Uncertain significance Single submitter
- CWC22 p.Asp842Glu Uncertain significance Single submitter
- CWC22 p.Asp869Gly Uncertain significance Single submitter
- CWC22 p.Gln110Leu Uncertain significance Single submitter
- CWC22 p.Gln417Arg Uncertain significance Single submitter
- CWC22 p.Gln7Pro Uncertain significance Single submitter
- CWC22 p.Gln896Arg Uncertain significance Single submitter
- CWC22 p.Glu504Ala Uncertain significance Single submitter
- CWC22 p.Glu700Asp Uncertain significance Single submitter
- CWC22 p.Glu700Gly Uncertain significance Single submitter
- CWC22 p.Glu729Lys Uncertain significance Single submitter
- CWC22 p.Glu759Lys Uncertain significance Single submitter
- CWC22 p.Glu813Lys Uncertain significance Single submitter
- CWC22 p.Glu876Lys Uncertain significance Single submitter
- CWC22 p.Glu901Gly Uncertain significance Single submitter
- CWC22 p.Gly527Asp Uncertain significance Single submitter
- CWC22 p.Gly595Arg Uncertain significance Single submitter
- CWC22 p.Gly817Ala Uncertain significance Single submitter
- CWC22 p.Gly863Arg Uncertain significance Single submitter
- CWC22 p.His14Asp Uncertain significance Single submitter
- CWC22 p.His816Arg Uncertain significance Single submitter
- CWC22 p.His836Arg Uncertain significance Single submitter
- CWC22 p.His836Tyr Uncertain significance Single submitter
- CWC22 p.Ile170Thr Uncertain significance Single submitter
- CWC22 p.Ile264Thr Uncertain significance Single submitter
- CWC22 p.Ile322Thr Uncertain significance Single submitter
- CWC22 p.Ile568Val Uncertain significance Single submitter
- CWC22 p.Ile734Val Uncertain significance Single submitter
- CWC22 p.Leu218Ser Uncertain significance Single submitter
- CWC22 p.Leu278Phe Uncertain significance Single submitter
- CWC22 p.Leu489Phe Uncertain significance Single submitter
- CWC22 p.Lys118Arg Uncertain significance Single submitter
- CWC22 p.Lys598Arg Uncertain significance Single submitter
- CWC22 p.Lys893Glu Uncertain significance Single submitter
- CWC22 p.Met339Ile Uncertain significance Single submitter
- CWC22 p.Met387Val Uncertain significance Single submitter
- CWC22 p.Met522Val Uncertain significance Single submitter
- CWC22 p.Pro40Arg Uncertain significance Single submitter
- CWC22 p.Pro40Leu Uncertain significance Single submitter
- CWC22 p.Pro617Ser Uncertain significance Single submitter
- CWC22 p.Pro904Ala Uncertain significance Single submitter
- CWC22 p.Pro99Thr Uncertain significance Single submitter
- CWC22 p.Ser107Thr Uncertain significance Single submitter
- CWC22 p.Ser176Pro Uncertain significance Single submitter
- CWC22 p.Ser3Asn Uncertain significance Single submitter
- CWC22 p.Ser866Asn Uncertain significance Single submitter
- CWC22 p.Thr127Ile Uncertain significance Single submitter
- CWC22 p.Thr212Ile Uncertain significance Single submitter
- CWC22 p.Thr725Ala Uncertain significance Single submitter
- CWC22 p.Thr739Ala Uncertain significance Single submitter
- CWC22 p.Trp159Arg Uncertain significance Single submitter
- CWC22 p.Val103Ile Uncertain significance Single submitter
- CWC22 p.Val260Leu Uncertain significance Single submitter
- CWC22 p.Val381Ile Uncertain significance Single submitter
- CWC22 p.Val547Leu Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- CWC22 p.Arg128Pro Uncertain significance Single submitter
- CWC22 p.Arg17Thr Uncertain significance Single submitter
- CWC22 p.Arg246Gln Uncertain significance Single submitter
- CWC22 p.Arg41Gln Uncertain significance Single submitter
- CWC22 p.Arg41Trp Uncertain significance Single submitter
- CWC22 p.Arg43Thr Uncertain significance Single submitter
- CWC22 p.Arg73Gln Uncertain significance Single submitter
- CWC22 p.Arg81Lys Uncertain significance Single submitter
- CWC22 p.Arg847Gly Uncertain significance Single submitter
- CWC22 p.Arg859Gly Uncertain significance Single submitter
- CWC22 p.Arg85Gln Uncertain significance Single submitter
- CWC22 p.Arg85Trp Uncertain significance Single submitter
- CWC22 p.Arg877Thr Uncertain significance Single submitter
- CWC22 p.Arg89Trp Uncertain significance Single submitter
- CWC22 p.Asp123Ala Uncertain significance Single submitter
- CWC22 p.Asp416Gly Uncertain significance Single submitter
- CWC22 p.Gln251Lys Uncertain significance Single submitter
- CWC22 p.Glu432Ala Uncertain significance Single submitter
- CWC22 p.Glu480Ala Uncertain significance Single submitter
- CWC22 p.Glu695Ala Uncertain significance Single submitter
- CWC22 p.Glu74Gly Uncertain significance Single submitter
- CWC22 p.Ile336Val Uncertain significance Single submitter
- CWC22 p.Ile493Val Uncertain significance Single submitter
- CWC22 p.Ile654Thr Uncertain significance Single submitter
- CWC22 p.Leu359Met Uncertain significance Single submitter
- CWC22 p.Leu560Phe Uncertain significance Single submitter
- CWC22 p.Lys235Arg Uncertain significance Single submitter
- CWC22 p.Lys330Arg Uncertain significance Single submitter
- CWC22 p.Lys598Gln Uncertain significance Single submitter
- CWC22 p.Met277Ile Uncertain significance Single submitter
- CWC22 p.Met594Val Uncertain significance Single submitter
- CWC22 p.Pro389Ser Uncertain significance Single submitter
- CWC22 p.Ser421Arg Uncertain significance Single submitter
- CWC22 p.Ser422Asn Uncertain significance Single submitter
- CWC22 p.Ser685Cys Uncertain significance Single submitter
- CWC22 p.Ser687Cys Uncertain significance Single submitter
- CWC22 p.Ser692Cys Uncertain significance Single submitter
- CWC22 p.Ser693Asn Uncertain significance Single submitter
- CWC22 p.Ser772Ala Uncertain significance Single submitter
- CWC22 p.Ser882Cys Uncertain significance Single submitter
- CWC22 p.Ser93Cys Uncertain significance Single submitter
- CWC22 p.Tyr33Cys Uncertain significance Single submitter
- CWC22 p.Tyr45Cys Uncertain significance Single submitter
- CWC22 p.Val290Ile Uncertain significance Single submitter
- CWC22 p.Val307Leu Uncertain significance Single submitter
All CWC22 variants
Benign 4
- p.Asp741Val Multiple submitters
- p.Gln365= Multiple submitters
- c.1147+2dup Single submitter
- c.2141-5C>T Single submitter
Likely benign 7
- p.Ala216= Single submitter
- p.Arg60His Single submitter
- p.Asn736Lys Single submitter
- p.Asp789Gly Single submitter
- p.Ser798Asn Single submitter
- p.Thr115Ala Single submitter
- p.Thr83Met Single submitter
Uncertain significance 120
- p.Ala419Thr Single submitter ⚠
- p.Ala674Ser Single submitter ⚠
- p.Arg128Pro Single submitter ⚠
- p.Arg156Lys Single submitter ⚠
- p.Arg17Thr Single submitter ⚠
- p.Arg236Thr Single submitter ⚠
- p.Arg246Gln Single submitter ⚠
- p.Arg246Gly Single submitter ⚠
- p.Arg318His Single submitter ⚠
- p.Arg320Gln Single submitter ⚠
- p.Arg343Trp Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg43Thr Single submitter ⚠
- p.Arg456His Single submitter ⚠
- p.Arg457His Single submitter ⚠
- p.Arg644Gln Single submitter ⚠
- p.Arg73Gln Single submitter ⚠
- p.Arg81Lys Single submitter ⚠
- p.Arg823Ser Single submitter ⚠
- p.Arg847Gly Single submitter ⚠
- p.Arg859Gly Single submitter ⚠
- p.Arg85Gln Single submitter ⚠
- p.Arg85Trp Single submitter ⚠
- p.Arg870Gly Single submitter ⚠
- p.Arg877Thr Single submitter ⚠
- p.Arg89Trp Single submitter ⚠
- p.Asn223Ser Single submitter ⚠
- p.Asn70His Single submitter ⚠
- p.Asn873Ser Single submitter ⚠
- p.Asp123Ala Single submitter ⚠
- p.Asp15Asn Single submitter ⚠
- p.Asp388Tyr Single submitter ⚠
- p.Asp416Gly Single submitter ⚠
- p.Asp436Glu Single submitter ⚠
- p.Asp769Asn Single submitter ⚠
- p.Asp818His Single submitter ⚠
- p.Asp842Glu Single submitter ⚠
- p.Asp869Gly Single submitter ⚠
- p.Gln110Leu Single submitter ⚠
- p.Gln251Lys Single submitter ⚠
- p.Gln417Arg Single submitter ⚠
- p.Gln7Pro Single submitter ⚠
- p.Gln896Arg Single submitter ⚠
- p.Glu432Ala Single submitter ⚠
- p.Glu480Ala Single submitter ⚠
- p.Glu504Ala Single submitter ⚠
- p.Glu695Ala Single submitter ⚠
- p.Glu700Asp Single submitter ⚠
- p.Glu700Gly Single submitter ⚠
- p.Glu729Lys Single submitter ⚠
- p.Glu74Gly Single submitter ⚠
- p.Glu759Lys Single submitter ⚠
- p.Glu813Lys Single submitter ⚠
- p.Glu876Lys Single submitter ⚠
- p.Glu901Gly Single submitter ⚠
- p.Gly527Asp Single submitter ⚠
- p.Gly595Arg Single submitter ⚠
- p.Gly817Ala Single submitter ⚠
- p.Gly863Arg Single submitter ⚠
- p.His14Asp Single submitter ⚠
- p.His816Arg Single submitter ⚠
- p.His836Arg Single submitter ⚠
- p.His836Tyr Single submitter ⚠
- p.Ile170Thr Single submitter ⚠
- p.Ile264Thr Single submitter ⚠
- p.Ile322Thr Single submitter ⚠
- p.Ile336Val Single submitter ⚠
- p.Ile493Val Single submitter ⚠
- p.Ile568Val Single submitter ⚠
- p.Ile654Thr Single submitter ⚠
- p.Ile734Val Single submitter ⚠
- p.Leu218Ser Single submitter ⚠
- p.Leu278Phe Single submitter ⚠
- p.Leu359Met Single submitter ⚠
- p.Leu489Phe Single submitter ⚠
- p.Leu560Phe Single submitter ⚠
- p.Lys118Arg Single submitter ⚠
- p.Lys235Arg Single submitter ⚠
- p.Lys330Arg Single submitter ⚠
- p.Lys598Arg Single submitter ⚠
- p.Lys598Gln Single submitter ⚠
- p.Lys893Glu Single submitter ⚠
- p.Met277Ile Single submitter ⚠
- p.Met339Ile Single submitter ⚠
- p.Met387Val Single submitter ⚠
- p.Met522Val Single submitter ⚠
- p.Met594Val Single submitter ⚠
- p.Pro389Ser Single submitter ⚠
- p.Pro40Arg Single submitter ⚠
- p.Pro40Leu Single submitter ⚠
- p.Pro617Ser Single submitter ⚠
- p.Pro904Ala Single submitter ⚠
- p.Pro99Thr Single submitter ⚠
- p.Ser107Thr Single submitter ⚠
- p.Ser176Pro Single submitter ⚠
- p.Ser3Asn Single submitter ⚠
- p.Ser421Arg Single submitter ⚠
- p.Ser422Asn Single submitter ⚠
- p.Ser685Cys Single submitter ⚠
- p.Ser687Cys Single submitter ⚠
- p.Ser692Cys Single submitter ⚠
- p.Ser693Asn Single submitter ⚠
- p.Ser772Ala Single submitter ⚠
- p.Ser866Asn Single submitter ⚠
- p.Ser882Cys Single submitter ⚠
- p.Ser93Cys Single submitter ⚠
- p.Thr127Ile Single submitter ⚠
- p.Thr212Ile Single submitter ⚠
- p.Thr725Ala Single submitter ⚠
- p.Thr739Ala Single submitter ⚠
- p.Trp159Arg Single submitter ⚠
- p.Tyr33Cys Single submitter ⚠
- p.Tyr45Cys Single submitter ⚠
- p.Val103Ile Single submitter ⚠
- p.Val260Leu Single submitter ⚠
- p.Val290Ile Single submitter ⚠
- p.Val307Leu Single submitter ⚠
- p.Val381Ile Single submitter ⚠
- p.Val547Leu Single submitter ⚠