CWC25 — 68 ClinVar variants
All ClinVar germline CWC25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
4 Likely benign · 64 Uncertain significance
Full CWC25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CWC25 p.Ala124Gly Uncertain significance Single submitter
- CWC25 p.Ala329Val Uncertain significance Single submitter
- CWC25 p.Ala367Ser Uncertain significance Single submitter
- CWC25 p.Ala367Thr Uncertain significance Single submitter
- CWC25 p.Arg135Trp Uncertain significance Single submitter
- CWC25 p.Arg198Cys Uncertain significance Single submitter
- CWC25 p.Arg232Gln Uncertain significance Single submitter
- CWC25 p.Arg250Ser Uncertain significance Single submitter
- CWC25 p.Arg345Trp Uncertain significance Single submitter
- CWC25 p.Arg372Gln Uncertain significance Single submitter
- CWC25 p.Arg42Gln Uncertain significance Single submitter
- CWC25 p.Asn125Ser Uncertain significance Single submitter
- CWC25 p.Asn216Asp Uncertain significance Single submitter
- CWC25 p.Asp203Glu Uncertain significance Single submitter
- CWC25 p.Glu172Lys Uncertain significance Single submitter
- CWC25 p.Gly228Ser Uncertain significance Single submitter
- CWC25 p.Gly331Val Uncertain significance Single submitter
- CWC25 p.His186Arg Uncertain significance Single submitter
- CWC25 p.Ile134Thr Uncertain significance Single submitter
- CWC25 p.Ile408Met Uncertain significance Single submitter
- CWC25 p.Ile408Thr Uncertain significance Single submitter
- CWC25 p.Ile92Thr Uncertain significance Single submitter
- CWC25 p.Leu240Phe Uncertain significance Single submitter
- CWC25 p.Leu87Pro Uncertain significance Single submitter
- CWC25 p.Lys212Asn Uncertain significance Single submitter
- CWC25 p.Lys300Thr Uncertain significance Single submitter
- CWC25 p.Lys364Arg Uncertain significance Single submitter
- CWC25 p.Lys420Asn Uncertain significance Single submitter
- CWC25 p.Met130Ile Uncertain significance Single submitter
- CWC25 p.Met214Leu Uncertain significance Single submitter
- CWC25 p.Pro219Ser Uncertain significance Single submitter
- CWC25 p.Ser210Pro Uncertain significance Single submitter
- CWC25 p.Thr245Ala Uncertain significance Single submitter
- CWC25 p.Thr333Ser Uncertain significance Single submitter
- CWC25 p.Val231Phe Uncertain significance Single submitter
- CWC25 p.Val63Ile Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CWC25 p.Arg135Gln Uncertain significance Single submitter
- CWC25 p.Arg151Gln Uncertain significance Single submitter
- CWC25 p.Arg236Cys Uncertain significance Single submitter
- CWC25 p.Arg343Gln Uncertain significance Single submitter
- CWC25 p.Arg382Trp Uncertain significance Single submitter
- CWC25 p.Arg389Pro Uncertain significance Single submitter
- CWC25 p.Arg403Gln Uncertain significance Single submitter
- CWC25 p.Arg48Lys Uncertain significance Single submitter
- CWC25 p.Arg55His Uncertain significance Single submitter
- CWC25 p.Arg83His Uncertain significance Single submitter
- CWC25 p.Gln168Leu Uncertain significance Single submitter
- CWC25 p.Glu202Lys Uncertain significance Single submitter
- CWC25 p.Glu68Gly Uncertain significance Single submitter
- CWC25 p.Gly331Arg Uncertain significance Single submitter
- CWC25 p.Leu128Pro Uncertain significance Single submitter
- CWC25 p.Leu336Phe Uncertain significance Single submitter
- CWC25 p.Leu379Pro Uncertain significance Single submitter
- CWC25 p.Lys144Arg Uncertain significance Single submitter
- CWC25 p.Lys182Glu Uncertain significance Single submitter
- CWC25 p.Lys184Arg Uncertain significance Single submitter
- CWC25 p.Lys368Met Uncertain significance Single submitter
- CWC25 p.Phe422Ser Uncertain significance Single submitter
- CWC25 p.Phe422Val Uncertain significance Single submitter
- CWC25 p.Pro267Leu Uncertain significance Single submitter
- CWC25 p.Ser201Arg Uncertain significance Single submitter
- CWC25 p.Ser275Thr Uncertain significance Single submitter
- CWC25 p.Trp354Arg Uncertain significance Single submitter
- CWC25 p.Tyr74Phe Uncertain significance Single submitter
All CWC25 variants
Likely benign 4
- p.Arg236His Single submitter
- p.Arg334= Single submitter
- p.Ser195= Single submitter
- p.Val231Ile Single submitter
Uncertain significance 64
- p.Ala124Gly Single submitter ⚠
- p.Ala329Val Single submitter ⚠
- p.Ala367Ser Single submitter ⚠
- p.Ala367Thr Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg135Trp Single submitter ⚠
- p.Arg151Gln Single submitter ⚠
- p.Arg198Cys Single submitter ⚠
- p.Arg232Gln Single submitter ⚠
- p.Arg236Cys Single submitter ⚠
- p.Arg250Ser Single submitter ⚠
- p.Arg343Gln Single submitter ⚠
- p.Arg345Trp Single submitter ⚠
- p.Arg372Gln Single submitter ⚠
- p.Arg382Trp Single submitter ⚠
- p.Arg389Pro Single submitter ⚠
- p.Arg403Gln Single submitter ⚠
- p.Arg42Gln Single submitter ⚠
- p.Arg48Lys Single submitter ⚠
- p.Arg55His Single submitter ⚠
- p.Arg83His Single submitter ⚠
- p.Asn125Ser Single submitter ⚠
- p.Asn216Asp Single submitter ⚠
- p.Asp203Glu Single submitter ⚠
- p.Gln168Leu Single submitter ⚠
- p.Glu172Lys Single submitter ⚠
- p.Glu202Lys Single submitter ⚠
- p.Glu68Gly Single submitter ⚠
- p.Gly228Ser Single submitter ⚠
- p.Gly331Arg Single submitter ⚠
- p.Gly331Val Single submitter ⚠
- p.His186Arg Single submitter ⚠
- p.Ile134Thr Single submitter ⚠
- p.Ile408Met Single submitter ⚠
- p.Ile408Thr Single submitter ⚠
- p.Ile92Thr Single submitter ⚠
- p.Leu128Pro Single submitter ⚠
- p.Leu240Phe Single submitter ⚠
- p.Leu336Phe Single submitter ⚠
- p.Leu379Pro Single submitter ⚠
- p.Leu87Pro Single submitter ⚠
- p.Lys144Arg Single submitter ⚠
- p.Lys182Glu Single submitter ⚠
- p.Lys184Arg Single submitter ⚠
- p.Lys212Asn Single submitter ⚠
- p.Lys300Thr Single submitter ⚠
- p.Lys364Arg Single submitter ⚠
- p.Lys368Met Single submitter ⚠
- p.Lys420Asn Single submitter ⚠
- p.Met130Ile Single submitter ⚠
- p.Met214Leu Single submitter ⚠
- p.Phe422Ser Single submitter ⚠
- p.Phe422Val Single submitter ⚠
- p.Pro219Ser Single submitter ⚠
- p.Pro267Leu Single submitter ⚠
- p.Ser201Arg Single submitter ⚠
- p.Ser210Pro Single submitter ⚠
- p.Ser275Thr Single submitter ⚠
- p.Thr245Ala Single submitter ⚠
- p.Thr333Ser Single submitter ⚠
- p.Trp354Arg Single submitter ⚠
- p.Tyr74Phe Single submitter ⚠
- p.Val231Phe Single submitter ⚠
- p.Val63Ile Single submitter ⚠