CWF19L2 — 149 ClinVar variants

All ClinVar germline CWF19L2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 144 flagged for review →

5 Likely benign · 144 Uncertain significance

Full CWF19L2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 144

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 81

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 63

The independent predictors disagree with each other — read with care.

All CWF19L2 variants

Likely benign 5

p.Arg284Gln Single submitter
p.Ile67= Single submitter
p.Lys143= Single submitter
p.Ser436Leu Single submitter
p.Val557= Single submitter

Uncertain significance 144

p.Ala15Val Single submitter ⚠
p.Ala28Val Single submitter ⚠
p.Ala522Thr Single submitter ⚠
p.Ala691Gly Single submitter ⚠
p.Ala781Thr Single submitter ⚠
p.Arg286Trp Single submitter ⚠
p.Arg317Ile Single submitter ⚠
p.Arg421Cys Single submitter ⚠
p.Arg46Cys Single submitter ⚠
p.Arg470Trp Single submitter ⚠
p.Arg482Cys Single submitter ⚠
p.Arg53Trp Single submitter ⚠
p.Arg574Ile Single submitter ⚠
p.Arg704Trp Single submitter ⚠
p.Asn329Asp Single submitter ⚠
p.Asn411Ser Single submitter ⚠
p.Asn702Ser Single submitter ⚠
p.Asn799Ile Single submitter ⚠
p.Asp129Val Single submitter ⚠
p.Asp204Gly Single submitter ⚠
p.Asp213Glu Single submitter ⚠
p.Asp227Val Single submitter ⚠
p.Asp271Gly Single submitter ⚠
p.Asp281Gly Single submitter ⚠
p.Asp316Val Single submitter ⚠
p.Asp461Ala Single submitter ⚠
p.Asp471Tyr Single submitter ⚠
p.Asp491Gly Single submitter ⚠
p.Asp542Asn Single submitter ⚠
p.Asp638Gly Single submitter ⚠
p.Asp809Asn Single submitter ⚠
p.Asp837Tyr Single submitter ⚠
p.Asp855Ala Single submitter ⚠
p.Cys214Gly Single submitter ⚠
p.Cys699Tyr Single submitter ⚠
p.Cys751Tyr Single submitter ⚠
p.Gln182Lys Single submitter ⚠
p.Gln24Lys Single submitter ⚠
p.Gln266Arg Single submitter ⚠
p.Gln398Arg Single submitter ⚠
p.Gln570Pro Single submitter ⚠
p.Gln763Arg Single submitter ⚠
p.Gln763His Single submitter ⚠
p.Glu195Gly Single submitter ⚠
p.Glu257Lys Single submitter ⚠
p.Glu301Gln Single submitter ⚠
p.Glu330Ala Single submitter ⚠
p.Glu358Lys Single submitter ⚠
p.Glu376Gly Single submitter ⚠
p.Glu387Gln Single submitter ⚠
p.Glu41Gly Single submitter ⚠
p.Glu41Val Single submitter ⚠
p.Glu44Lys Single submitter ⚠
p.Glu545Gly Single submitter ⚠
p.Glu55Gly Single submitter ⚠
p.Glu568Asp Single submitter ⚠
p.Glu92Asp Single submitter ⚠
p.Gly142Arg Single submitter ⚠
p.Gly362Arg Single submitter ⚠
p.Gly399Ser Single submitter ⚠
p.Gly426Arg Single submitter ⚠
p.Gly54Val Single submitter ⚠
p.Gly555Arg Single submitter ⚠
p.Gly564Arg Single submitter ⚠
p.Gly571Glu Single submitter ⚠
p.Gly693Asp Single submitter ⚠
p.Gly693Val Single submitter ⚠
p.Gly817Glu Single submitter ⚠
p.Gly852Ala Single submitter ⚠
p.His710Asn Single submitter ⚠
p.His718Arg Single submitter ⚠
p.His833Arg Single submitter ⚠
p.His839Gln Single submitter ⚠
p.Ile18Val Single submitter ⚠
p.Ile264Val Single submitter ⚠
p.Ile485Phe Single submitter ⚠
p.Ile487Met Single submitter ⚠
p.Ile662Val Single submitter ⚠
p.Ile713Val Single submitter ⚠
p.Ile783Val Single submitter ⚠
p.Ile789Met Single submitter ⚠
p.Ile789Val Single submitter ⚠
p.Ile835Thr Single submitter ⚠
p.Ile835Val Single submitter ⚠
p.Ile856Val Single submitter ⚠
p.Leu488Pro Single submitter ⚠
p.Leu49Pro Single submitter ⚠
p.Leu802Phe Single submitter ⚠
p.Leu877Pro Single submitter ⚠
p.Lys163Asn Single submitter ⚠
p.Lys221Glu Single submitter ⚠
p.Lys565Thr Single submitter ⚠
p.Lys607Glu Single submitter ⚠
p.Lys643Arg Single submitter ⚠
p.Lys659Glu Single submitter ⚠
p.Lys660Gln Single submitter ⚠
p.Lys801Asn Single submitter ⚠
p.Lys81Glu Single submitter ⚠
p.Lys874Arg Single submitter ⚠
p.Lys875Glu Single submitter ⚠
p.Met262Val Single submitter ⚠
p.Met506Ile Single submitter ⚠
p.Met626Val Single submitter ⚠
p.Met735Val Single submitter ⚠
p.Met760Arg Single submitter ⚠
p.Met766Val Single submitter ⚠
p.Phe361Ser Single submitter ⚠
p.Pro200Leu Single submitter ⚠
p.Pro211Arg Single submitter ⚠
p.Pro211Ser Single submitter ⚠
p.Pro480Leu Single submitter ⚠
p.Pro782Ala Single submitter ⚠
p.Pro819Leu Single submitter ⚠
p.Ser109Phe Single submitter ⚠
p.Ser141Ala Single submitter ⚠
p.Ser168Leu Single submitter ⚠
p.Ser231Asn Single submitter ⚠
p.Ser372Phe Single submitter ⚠
p.Ser390Arg Single submitter ⚠
p.Ser390Cys Single submitter ⚠
p.Ser412Gly Single submitter ⚠
p.Ser418Leu Single submitter ⚠
p.Ser536Phe Single submitter ⚠
p.Ser580Leu Single submitter ⚠
p.Ser667Cys Single submitter ⚠
p.Ser681Gly Single submitter ⚠
p.Ser705Cys Single submitter ⚠
p.Ser822Phe Single submitter ⚠
p.Thr220Ala Single submitter ⚠
p.Thr346Ala Single submitter ⚠
p.Thr346Met Single submitter ⚠
p.Thr3Ala Single submitter ⚠
p.Thr562Pro Single submitter ⚠
p.Thr581Ala Single submitter ⚠
p.Tyr237Phe Single submitter ⚠
p.Tyr633Cys Single submitter ⚠
p.Tyr633His Single submitter ⚠
p.Tyr768Cys Single submitter ⚠
p.Tyr784Cys Single submitter ⚠
p.Tyr844Ser Single submitter ⚠
p.Val224Glu Single submitter ⚠
p.Val225Ile Single submitter ⚠
p.Val490Ala Single submitter ⚠
p.Val741Leu Single submitter ⚠