CXADR — 55 ClinVar variants
All ClinVar germline CXADR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Benign · 8 Likely benign · 46 Uncertain significance
Full CXADR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXADR p.Ala144Val Uncertain significance Single submitter
- CXADR p.Arg217Lys Uncertain significance Single submitter
- CXADR p.Arg226Pro Uncertain significance Single submitter
- CXADR p.Arg287Cys Uncertain significance Single submitter
- CXADR p.Arg328His Uncertain significance Single submitter
- CXADR p.Arg90Gln Uncertain significance Single submitter
- CXADR p.Asn298Ser Uncertain significance Single submitter
- CXADR p.Asp361Asn Uncertain significance Single submitter
- CXADR p.Asp77Gly Uncertain significance Single submitter
- CXADR p.Gln119His Uncertain significance Single submitter
- CXADR p.Glu48Lys Uncertain significance Single submitter
- CXADR p.Glu56Lys Uncertain significance Single submitter
- CXADR p.Gly241Glu Uncertain significance Single submitter
- CXADR p.Gly296Ser Uncertain significance Single submitter
- CXADR p.Ile364Val Uncertain significance Single submitter
- CXADR p.Met305Val Uncertain significance Single submitter
- CXADR p.Phe258Leu Uncertain significance Single submitter
- CXADR p.Pro322Ser Uncertain significance Single submitter
- CXADR p.Ser21Asn Uncertain significance Single submitter
- CXADR p.Ser289Tyr Uncertain significance Single submitter
- CXADR p.Ser363Phe Uncertain significance Single submitter
- CXADR p.Ser46Asn Uncertain significance Single submitter
- CXADR p.Thr246Ala Uncertain significance Single submitter
- CXADR p.Tyr269Asn Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- CXADR p.Ala251Val Likely benign Single submitter
- CXADR p.Arg261His Likely benign Single submitter
- CXADR p.Arg264Cys Uncertain significance Single submitter
- CXADR p.Asp361Glu Uncertain significance Single submitter
- CXADR p.Asp97Gly Uncertain significance Single submitter
- CXADR p.Ile105Leu Uncertain significance Single submitter
- CXADR p.Ile22Leu Uncertain significance Single submitter
- CXADR p.Ile239Phe Uncertain significance Single submitter
- CXADR p.Ile239Thr Uncertain significance Single submitter
- CXADR p.Leu250Val Uncertain significance Single submitter
- CXADR p.Leu255Phe Uncertain significance Single submitter
- CXADR p.Leu345Arg Uncertain significance Single submitter
- CXADR p.Leu9Phe Uncertain significance Single submitter
- CXADR p.Lys165Asn Uncertain significance Single submitter
- CXADR p.Lys42Arg Uncertain significance Single submitter
- CXADR p.Lys99Glu Uncertain significance Single submitter
- CXADR p.Met354Thr Uncertain significance Single submitter
- CXADR p.Pro52Leu Uncertain significance Single submitter
- CXADR p.Ser359Arg Uncertain significance Single submitter
- CXADR p.Thr108Met Uncertain significance Single submitter
- CXADR p.Thr117Ser Uncertain significance Single submitter
- CXADR p.Thr290Ile Uncertain significance Single submitter
- CXADR p.Thr94Met Uncertain significance Single submitter
- CXADR p.Tyr74His Uncertain significance Single submitter
All CXADR variants
Benign 1
- p.Thr193= Multiple submitters
Likely benign 8
- p.Ala251Val Single submitter ⚠
- p.Arg261His Single submitter ⚠
- p.Glu311= Single submitter
- p.Ile295= Single submitter
- p.Pro333= Single submitter
- p.Thr288= Single submitter
- p.Thr290= Single submitter
- p.Thr334= Single submitter
Uncertain significance 46
- p.Ala144Val Single submitter ⚠
- p.Arg217Lys Single submitter ⚠
- p.Arg226Pro Single submitter ⚠
- p.Arg264Cys Single submitter ⚠
- p.Arg287Cys Single submitter ⚠
- p.Arg328His Single submitter ⚠
- p.Arg90Gln Single submitter ⚠
- p.Asn298Ser Single submitter ⚠
- p.Asp361Asn Single submitter ⚠
- p.Asp361Glu Single submitter ⚠
- p.Asp77Gly Single submitter ⚠
- p.Asp97Gly Single submitter ⚠
- p.Gln119His Single submitter ⚠
- p.Glu48Lys Single submitter ⚠
- p.Glu56Lys Single submitter ⚠
- p.Gly241Glu Single submitter ⚠
- p.Gly296Ser Single submitter ⚠
- p.Ile105Leu Single submitter ⚠
- p.Ile22Leu Single submitter ⚠
- p.Ile239Phe Single submitter ⚠
- p.Ile239Thr Single submitter ⚠
- p.Ile364Val Single submitter ⚠
- p.Leu250Val Single submitter ⚠
- p.Leu255Phe Single submitter ⚠
- p.Leu345Arg Single submitter ⚠
- p.Leu9Phe Single submitter ⚠
- p.Lys165Asn Single submitter ⚠
- p.Lys42Arg Single submitter ⚠
- p.Lys99Glu Single submitter ⚠
- p.Met305Val Single submitter ⚠
- p.Met354Thr Single submitter ⚠
- p.Phe258Leu Single submitter ⚠
- p.Pro322Ser Single submitter ⚠
- p.Pro52Leu Single submitter ⚠
- p.Ser21Asn Single submitter ⚠
- p.Ser289Tyr Single submitter ⚠
- p.Ser359Arg Single submitter ⚠
- p.Ser363Phe Single submitter ⚠
- p.Ser46Asn Single submitter ⚠
- p.Thr108Met Single submitter ⚠
- p.Thr117Ser Single submitter ⚠
- p.Thr246Ala Single submitter ⚠
- p.Thr290Ile Single submitter ⚠
- p.Thr94Met Single submitter ⚠
- p.Tyr269Asn Single submitter ⚠
- p.Tyr74His Single submitter ⚠