CXCL1 — 25 ClinVar variants
All ClinVar germline CXCL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Benign · 4 Likely benign · 20 Uncertain significance
Full CXCL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCL1 p.Ala33Thr Uncertain significance Single submitter
- CXCL1 p.Ala4Pro Uncertain significance Single submitter
- CXCL1 p.Ala4Thr Uncertain significance Single submitter
- CXCL1 p.Ala9Thr Uncertain significance Single submitter
- CXCL1 p.Arg14Trp Uncertain significance Single submitter
- CXCL1 p.Arg17Leu Uncertain significance Single submitter
- CXCL1 p.Arg31His Uncertain significance Single submitter
- CXCL1 p.Gln44Glu Uncertain significance Single submitter
- CXCL1 p.Gln50Arg Uncertain significance Single submitter
- CXCL1 p.Gln50Lys Uncertain significance Single submitter
- CXCL1 p.Gly29Ser Uncertain significance Single submitter
- CXCL1 p.Gly51Arg Uncertain significance Single submitter
- CXCL1 p.His68Gln Uncertain significance Single submitter
- CXCL1 p.Lys99Met Uncertain significance Single submitter
- CXCL1 p.Pro10Ser Uncertain significance Single submitter
- CXCL1 p.Pro65Ser Uncertain significance Single submitter
- CXCL1 p.Ser11Gly Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CXCL1 variants
Benign 1
- p.Ala70Val Multiple submitters
Likely benign 4
- p.Arg82Gln Single submitter
- p.Asn61Lys Single submitter
- p.Lys83Glu Single submitter
- p.Pro54Leu Single submitter ⚠
Uncertain significance 20
- p.Ala33Thr Single submitter ⚠
- p.Ala4Pro Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Arg14Trp Single submitter ⚠
- p.Arg17Leu Single submitter ⚠
- p.Arg31His Single submitter ⚠
- p.Gln44Glu Single submitter ⚠
- p.Gln50Arg Single submitter ⚠
- p.Gln50Lys Single submitter ⚠
- p.Gly29Ser Single submitter ⚠
- p.Gly51Arg Single submitter ⚠
- p.His68Gln Single submitter ⚠
- p.Ile57Thr Single submitter ⚠
- p.Lys99Met Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro65Ser Single submitter ⚠
- p.Pro91Ser Single submitter ⚠
- p.Ser11Gly Single submitter ⚠
- p.Val62Met Single submitter ⚠