CXCL10 — 16 ClinVar variants

All ClinVar germline CXCL10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →

1 Benign · 2 Likely benign · 13 Uncertain significance

Full CXCL10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 13

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 13

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

All CXCL10 variants

Benign 1

p.Ala81= Multiple submitters

Likely benign 2

p.Arg59His Single submitter
p.Ile12Val Single submitter

Uncertain significance 13

p.Ala53Val Single submitter ⚠
p.Ala64Val Single submitter ⚠
p.Arg29His Single submitter ⚠
p.Arg93Ser Single submitter ⚠
p.Cys30Tyr Single submitter ⚠
p.Gln38Lys Single submitter ⚠
p.Ile82Val Single submitter ⚠
p.Leu24Pro Single submitter ⚠
p.Lys68Glu Single submitter ⚠
p.Pro42Ala Single submitter ⚠
p.Ser90Arg Single submitter ⚠
p.Val28Ala Single submitter ⚠
p.Val60Ile Single submitter ⚠