CXCL11 — 15 ClinVar variants
All ClinVar germline CXCL11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
1 Likely benign · 14 Uncertain significance
Full CXCL11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCL11 p.Gln20Pro Uncertain significance Single submitter
- CXCL11 p.Gln72Arg Uncertain significance Single submitter
- CXCL11 p.Gln81Leu Uncertain significance Single submitter
- CXCL11 p.Ile64Val Uncertain significance Single submitter
- CXCL11 p.Lys38Thr Uncertain significance Single submitter
- CXCL11 p.Lys78Asn Uncertain significance Single submitter
- CXCL11 p.Lys88Thr Uncertain significance Single submitter
- CXCL11 p.Met6Thr Uncertain significance Single submitter
- CXCL11 p.Thr17Ala Uncertain significance Single submitter
- CXCL11 p.Val12Leu Uncertain significance Single submitter
- CXCL11 p.Val89Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CXCL11 variants
Likely benign 1
- p.Ala16Thr Single submitter
Uncertain significance 14
- p.Arg29Cys Single submitter ⚠
- p.Gln20Pro Single submitter ⚠
- p.Gln72Arg Single submitter ⚠
- p.Gln81Leu Single submitter ⚠
- p.Ile45Thr Single submitter ⚠
- p.Ile64Val Single submitter ⚠
- p.Lys38Thr Single submitter ⚠
- p.Lys78Asn Single submitter ⚠
- p.Lys88Thr Single submitter ⚠
- p.Met6Thr Single submitter ⚠
- p.Phe25Leu Single submitter ⚠
- p.Thr17Ala Single submitter ⚠
- p.Val12Leu Single submitter ⚠
- p.Val89Ala Single submitter ⚠