CXCL13 — 9 ClinVar variants
All ClinVar germline CXCL13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
1 Likely benign · 8 Uncertain significance
Full CXCL13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCL13 p.Arg46Pro Uncertain significance Single submitter
- CXCL13 p.Arg56His Uncertain significance Single submitter
- CXCL13 p.Gln80Lys Uncertain significance Single submitter
- CXCL13 p.Glu38Lys Uncertain significance Single submitter
- CXCL13 p.Pro19Ser Uncertain significance Single submitter
- CXCL13 p.Thr29Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All CXCL13 variants
Likely benign 1
- p.Lys107Arg Single submitter
Uncertain significance 8
- p.Arg46Cys Single submitter ⚠
- p.Arg46Pro Single submitter ⚠
- p.Arg56His Single submitter ⚠
- p.Gln80Lys Single submitter ⚠
- p.Glu38Lys Single submitter ⚠
- p.Pro19Ser Single submitter ⚠
- p.Ser95Cys Single submitter ⚠
- p.Thr29Ile Single submitter ⚠