CXCL14 — 18 ClinVar variants
All ClinVar germline CXCL14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
1 Likely benign · 17 Uncertain significance
Full CXCL14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCL14 c.-2G>C Uncertain significance Single submitter
- CXCL14 p.Ala14Thr Uncertain significance Single submitter
- CXCL14 p.Ala6Thr Uncertain significance Single submitter
- CXCL14 p.Ala7Thr Uncertain significance Single submitter
- CXCL14 p.Asn88Asp Uncertain significance Single submitter
- CXCL14 p.Ile58Val Uncertain significance Single submitter
- CXCL14 p.Leu15Val Uncertain significance Single submitter
- CXCL14 p.Lys26Arg Uncertain significance Single submitter
- CXCL14 p.Lys45Arg Uncertain significance Single submitter
- CXCL14 p.Pro75Thr Uncertain significance Single submitter
- CXCL14 p.Val56Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CXCL14 p.Arg35His Uncertain significance Single submitter
- CXCL14 p.Arg67Gln Uncertain significance Single submitter
- CXCL14 p.Arg82His Uncertain significance Single submitter
- CXCL14 p.Ser64Pro Uncertain significance Single submitter
- CXCL14 p.Thr59Ser Uncertain significance Single submitter
- CXCL14 p.Val39Met Uncertain significance Single submitter
All CXCL14 variants
Likely benign 1
- p.Val63Met Single submitter
Uncertain significance 17
- c.-2G>C Single submitter ⚠
- p.Ala14Thr Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Ala7Thr Single submitter ⚠
- p.Arg35His Single submitter ⚠
- p.Arg67Gln Single submitter ⚠
- p.Arg82His Single submitter ⚠
- p.Asn88Asp Single submitter ⚠
- p.Ile58Val Single submitter ⚠
- p.Leu15Val Single submitter ⚠
- p.Lys26Arg Single submitter ⚠
- p.Lys45Arg Single submitter ⚠
- p.Pro75Thr Single submitter ⚠
- p.Ser64Pro Single submitter ⚠
- p.Thr59Ser Single submitter ⚠
- p.Val39Met Single submitter ⚠
- p.Val56Ile Single submitter ⚠