CXCL17 — 10 ClinVar variants
All ClinVar germline CXCL17 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
1 Benign · 9 Uncertain significance
Full CXCL17 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCL17 p.Ala29Thr Uncertain significance Single submitter
- CXCL17 p.Arg88Lys Uncertain significance Single submitter
- CXCL17 p.Cys110Arg Uncertain significance Single submitter
- CXCL17 p.Cys50Ser Uncertain significance Single submitter
- CXCL17 p.Gly69Glu Uncertain significance Single submitter
- CXCL17 p.Met15Ile Uncertain significance Single submitter
- CXCL17 p.Met65Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All CXCL17 variants
Benign 1
- p.Ser18= Multiple submitters
Uncertain significance 9
- p.Ala29Thr Single submitter ⚠
- p.Arg88Lys Single submitter ⚠
- p.Cys110Arg Single submitter ⚠
- p.Cys50Ser Single submitter ⚠
- p.Gly69Glu Single submitter ⚠
- p.Met15Ile Single submitter ⚠
- p.Met65Ile Single submitter ⚠
- p.Ser22Thr Single submitter ⚠
- p.Trp42Cys Single submitter ⚠