CXCL2 — 19 ClinVar variants
All ClinVar germline CXCL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
4 Likely benign · 15 Uncertain significance
Full CXCL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCL2 p.Arg14Gly Uncertain significance Single submitter
- CXCL2 p.Arg30Gly Uncertain significance Single submitter
- CXCL2 p.Arg30Trp Uncertain significance Single submitter
- CXCL2 p.Arg3Gly Uncertain significance Single submitter
- CXCL2 p.Gln50Arg Uncertain significance Single submitter
- CXCL2 p.Gly104Asp Uncertain significance Single submitter
- CXCL2 p.Lys61Arg Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- CXCL2 p.Ala27Ser Uncertain significance Single submitter
- CXCL2 p.Ala76Thr Uncertain significance Single submitter
- CXCL2 p.Ala89Val Uncertain significance Single submitter
- CXCL2 p.Arg14Gln Uncertain significance Single submitter
- CXCL2 p.Arg17Pro Uncertain significance Single submitter
- CXCL2 p.Gln50Leu Uncertain significance Single submitter
- CXCL2 p.Ile96Ser Uncertain significance Single submitter
- CXCL2 p.Ser7Tyr Uncertain significance Single submitter
All CXCL2 variants
Likely benign 4
- p.Ala38Val Single submitter
- p.Ala8Thr Single submitter
- p.Pro36Ser Single submitter
- p.Ser29Gly Single submitter
Uncertain significance 15
- p.Ala27Ser Single submitter ⚠
- p.Ala76Thr Single submitter ⚠
- p.Ala89Val Single submitter ⚠
- p.Arg14Gln Single submitter ⚠
- p.Arg14Gly Single submitter ⚠
- p.Arg17Pro Single submitter ⚠
- p.Arg30Gly Single submitter ⚠
- p.Arg30Trp Single submitter ⚠
- p.Arg3Gly Single submitter ⚠
- p.Gln50Arg Single submitter ⚠
- p.Gln50Leu Single submitter ⚠
- p.Gly104Asp Single submitter ⚠
- p.Ile96Ser Single submitter ⚠
- p.Lys61Arg Single submitter ⚠
- p.Ser7Tyr Single submitter ⚠