CXCL3 — 17 ClinVar variants
All ClinVar germline CXCL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
3 Likely benign · 14 Uncertain significance
Full CXCL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCL3 p.Ala2Gly Uncertain significance Single submitter
- CXCL3 p.Ala4Gly Uncertain significance Single submitter
- CXCL3 p.Ala8Ser Uncertain significance Single submitter
- CXCL3 p.Arg17Leu Uncertain significance Single submitter
- CXCL3 p.Arg42Gly Uncertain significance Single submitter
- CXCL3 p.Gln58Arg Uncertain significance Single submitter
- CXCL3 p.Ser64Phe Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CXCL3 p.Ala32Ser Uncertain significance Single submitter
- CXCL3 p.Ala32Val Uncertain significance Single submitter
- CXCL3 p.Ala84Ser Uncertain significance Single submitter
- CXCL3 p.Arg42His Uncertain significance Single submitter
- CXCL3 p.Leu49Arg Uncertain significance Single submitter
- CXCL3 p.Pro65Arg Uncertain significance Single submitter
- CXCL3 p.Ser59Cys Uncertain significance Single submitter
All CXCL3 variants
Likely benign 3
- p.Arg63Lys Single submitter
- p.Lys82Gln Single submitter
- p.Ser36Pro Single submitter
Uncertain significance 14
- p.Ala2Gly Single submitter ⚠
- p.Ala32Ser Single submitter ⚠
- p.Ala32Val Single submitter ⚠
- p.Ala4Gly Single submitter ⚠
- p.Ala84Ser Single submitter ⚠
- p.Ala8Ser Single submitter ⚠
- p.Arg17Leu Single submitter ⚠
- p.Arg42Gly Single submitter ⚠
- p.Arg42His Single submitter ⚠
- p.Gln58Arg Single submitter ⚠
- p.Leu49Arg Single submitter ⚠
- p.Pro65Arg Single submitter ⚠
- p.Ser59Cys Single submitter ⚠
- p.Ser64Phe Single submitter ⚠