CXCL5 — 26 ClinVar variants
All ClinVar germline CXCL5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
2 Likely benign · 24 Uncertain significance
Full CXCL5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCL5 p.Ala35Val Uncertain significance Single submitter
- CXCL5 p.Ala70Thr Uncertain significance Single submitter
- CXCL5 p.Arg45Gly Uncertain significance Single submitter
- CXCL5 p.Arg48Gly Uncertain significance Single submitter
- CXCL5 p.Cys75Tyr Uncertain significance Single submitter
- CXCL5 p.Gln53Arg Uncertain significance Single submitter
- CXCL5 p.Gln74Arg Uncertain significance Single submitter
- CXCL5 p.Glu113Gly Uncertain significance Single submitter
- CXCL5 p.Gly109Arg Uncertain significance Single submitter
- CXCL5 p.Gly32Val Uncertain significance Single submitter
- CXCL5 p.Ile71Met Uncertain significance Single submitter
- CXCL5 p.Pro12Arg Uncertain significance Single submitter
- CXCL5 p.Ser6Arg Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CXCL5 p.Ala8Val Uncertain significance Single submitter
- CXCL5 p.Ala96Val Uncertain significance Single submitter
- CXCL5 p.Arg10Cys Uncertain significance Single submitter
- CXCL5 p.Cys19Tyr Uncertain significance Single submitter
- CXCL5 p.Leu22Val Uncertain significance Single submitter
- CXCL5 p.Lys101Asn Uncertain significance Single submitter
- CXCL5 p.Pro73Arg Uncertain significance Single submitter
- CXCL5 p.Ser15Trp Uncertain significance Single submitter
- CXCL5 p.Ser2Asn Uncertain significance Single submitter
- CXCL5 p.Ser83Phe Uncertain significance Single submitter
- CXCL5 p.Thr54Ala Uncertain significance Single submitter
All CXCL5 variants
Likely benign 2
- p.Gly57Arg Single submitter
- p.Val102Ile Single submitter
Uncertain significance 24
- p.Ala35Val Single submitter ⚠
- p.Ala70Thr Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Ala96Val Single submitter ⚠
- p.Arg10Cys Single submitter ⚠
- p.Arg45Gly Single submitter ⚠
- p.Arg48Gly Single submitter ⚠
- p.Cys19Tyr Single submitter ⚠
- p.Cys75Tyr Single submitter ⚠
- p.Gln53Arg Single submitter ⚠
- p.Gln74Arg Single submitter ⚠
- p.Glu113Gly Single submitter ⚠
- p.Gly109Arg Single submitter ⚠
- p.Gly32Val Single submitter ⚠
- p.Ile71Met Single submitter ⚠
- p.Leu22Val Single submitter ⚠
- p.Lys101Asn Single submitter ⚠
- p.Pro12Arg Single submitter ⚠
- p.Pro73Arg Single submitter ⚠
- p.Ser15Trp Single submitter ⚠
- p.Ser2Asn Single submitter ⚠
- p.Ser6Arg Single submitter ⚠
- p.Ser83Phe Single submitter ⚠
- p.Thr54Ala Single submitter ⚠