CXCL6 — 20 ClinVar variants
All ClinVar germline CXCL6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
1 Benign · 19 Uncertain significance
Full CXCL6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCL6 p.Arg48Pro Uncertain significance Single submitter
- CXCL6 p.Cys75Arg Uncertain significance Single submitter
- CXCL6 p.Gly38Arg Uncertain significance Single submitter
- CXCL6 p.Gly38Val Uncertain significance Single submitter
- CXCL6 p.Leu99Val Uncertain significance Single submitter
- CXCL6 p.Lys61Arg Uncertain significance Single submitter
- CXCL6 p.Pro4Arg Uncertain significance Single submitter
- CXCL6 p.Pro4Thr Uncertain significance Single submitter
- CXCL6 p.Ser15Trp Uncertain significance Single submitter
- CXCL6 p.Thr29Met Uncertain significance Single submitter
- CXCL6 p.Val11Ala Uncertain significance Single submitter
- CXCL6 p.Val90Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CXCL6 p.Arg53Leu Uncertain significance Single submitter
- CXCL6 p.Asn114Asp Uncertain significance Single submitter
- CXCL6 p.Leu21Gln Uncertain significance Single submitter
- CXCL6 p.Lys101Asn Uncertain significance Single submitter
- CXCL6 p.Lys61Glu Uncertain significance Single submitter
- CXCL6 p.Lys85Arg Uncertain significance Single submitter
- CXCL6 p.Val80Gly Uncertain significance Single submitter
All CXCL6 variants
Benign 1
- p.Val81fs Single submitter
Uncertain significance 19
- p.Arg48Pro Single submitter ⚠
- p.Arg53Leu Single submitter ⚠
- p.Asn114Asp Single submitter ⚠
- p.Cys75Arg Single submitter ⚠
- p.Gly38Arg Single submitter ⚠
- p.Gly38Val Single submitter ⚠
- p.Leu21Gln Single submitter ⚠
- p.Leu99Val Single submitter ⚠
- p.Lys101Asn Single submitter ⚠
- p.Lys61Arg Single submitter ⚠
- p.Lys61Glu Single submitter ⚠
- p.Lys85Arg Single submitter ⚠
- p.Pro4Arg Single submitter ⚠
- p.Pro4Thr Single submitter ⚠
- p.Ser15Trp Single submitter ⚠
- p.Thr29Met Single submitter ⚠
- p.Val11Ala Single submitter ⚠
- p.Val80Gly Single submitter ⚠
- p.Val90Ile Single submitter ⚠