CXCL8 — 6 ClinVar variants
All ClinVar germline CXCL8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 3 flagged for review →
3 Likely benign · 3 Uncertain significance
Full CXCL8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 3
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All CXCL8 variants
Likely benign 3
- c.64+5G>C Single submitter
- p.Ala6= Single submitter
- p.Glu31Ter No assertion criteria CXCL8-related disorder
Uncertain significance 3
- p.Ile49Thr Single submitter ⚠
- p.Pro80His Single submitter ⚠
- p.Val85Met Single submitter ⚠