CXCL9 — 21 ClinVar variants
All ClinVar germline CXCL9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
1 Benign · 1 Likely benign · 19 Uncertain significance
Full CXCL9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCL9 p.Arg114Gln Uncertain significance Single submitter
- CXCL9 p.Arg118His Uncertain significance Single submitter
- CXCL9 p.Cys31Tyr Uncertain significance Single submitter
- CXCL9 p.Glu59Lys Uncertain significance Single submitter
- CXCL9 p.Lys97Thr Uncertain significance Single submitter
- CXCL9 p.Phe52Val Uncertain significance Single submitter
- CXCL9 p.Ser45Phe Uncertain significance Single submitter
- CXCL9 p.Val25Ala Uncertain significance Single submitter
- CXCL9 p.Val25Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CXCL9 p.Arg30His Uncertain significance Single submitter
- CXCL9 p.Gly11Asp Uncertain significance Single submitter
- CXCL9 p.Gly70Ala Uncertain significance Single submitter
- CXCL9 p.Ile34Ser Uncertain significance Single submitter
- CXCL9 p.Ile34Thr Uncertain significance Single submitter
- CXCL9 p.Ile41Thr Uncertain significance Single submitter
- CXCL9 p.Lys104Thr Uncertain significance Single submitter
- CXCL9 p.Lys108Glu Uncertain significance Single submitter
- CXCL9 p.Ser35Gly Uncertain significance Single submitter
- CXCL9 p.Ser79Leu Uncertain significance Single submitter
All CXCL9 variants
Benign 1
- p.Thr125= Single submitter
Likely benign 1
- p.Thr40Ser Single submitter
Uncertain significance 19
- p.Arg114Gln Single submitter ⚠
- p.Arg118His Single submitter ⚠
- p.Arg30His Single submitter ⚠
- p.Cys31Tyr Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Gly11Asp Single submitter ⚠
- p.Gly70Ala Single submitter ⚠
- p.Ile34Ser Single submitter ⚠
- p.Ile34Thr Single submitter ⚠
- p.Ile41Thr Single submitter ⚠
- p.Lys104Thr Single submitter ⚠
- p.Lys108Glu Single submitter ⚠
- p.Lys97Thr Single submitter ⚠
- p.Phe52Val Single submitter ⚠
- p.Ser35Gly Single submitter ⚠
- p.Ser45Phe Single submitter ⚠
- p.Ser79Leu Single submitter ⚠
- p.Val25Ala Single submitter ⚠
- p.Val25Leu Single submitter ⚠