CXCR1 — 77 ClinVar variants
All ClinVar germline CXCR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
3 Benign · 9 Likely benign · 65 Uncertain significance
Full CXCR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCR1 p.Ala196Val Uncertain significance Single submitter
- CXCR1 p.Ala97Ser Uncertain significance Single submitter
- CXCR1 p.Ala97Thr Uncertain significance Single submitter
- CXCR1 p.Arg150Cys Uncertain significance Single submitter
- CXCR1 p.Arg199Trp Uncertain significance Single submitter
-
CXCR1 p.Arg203Gln
Uncertain significance
Single submitter
susceptibility to HIV infection
- CXCR1 p.Arg203Trp Uncertain significance Single submitter
- CXCR1 p.Arg227Cys Uncertain significance Single submitter
- CXCR1 p.Arg279Pro Uncertain significance Single submitter
-
CXCR1 p.Arg280Cys
Uncertain significance
Single submitter
susceptibility to HIV infection
- CXCR1 p.Arg333Cys Uncertain significance Single submitter
- CXCR1 p.Arg71His Uncertain significance Single submitter
- CXCR1 p.Asn38Ile Uncertain significance Single submitter
- CXCR1 p.Asn57Lys Uncertain significance Single submitter
- CXCR1 p.Asp134Glu Uncertain significance Single submitter
- CXCR1 p.Asp288Val Uncertain significance Single submitter
- CXCR1 p.Asp85Asn Uncertain significance Single submitter
- CXCR1 p.Cys187Phe Uncertain significance Single submitter
- CXCR1 p.Glu275Asp Uncertain significance Single submitter
- CXCR1 p.Gly19Val Uncertain significance Single submitter
- CXCR1 p.Gly223Arg Uncertain significance Single submitter
- CXCR1 p.Gly284Ser Uncertain significance Single submitter
- CXCR1 p.His151Tyr Uncertain significance Single submitter
- CXCR1 p.His207Asp Uncertain significance Single submitter
- CXCR1 p.His334Arg Uncertain significance Single submitter
- CXCR1 p.Ile304Asn Uncertain significance Single submitter
- CXCR1 p.Leu158Phe Uncertain significance Single submitter
- CXCR1 p.Leu163Pro Uncertain significance Single submitter
- CXCR1 p.Leu205Met Uncertain significance Single submitter
- CXCR1 p.Leu293Pro Uncertain significance Single submitter
- CXCR1 p.Leu86Pro Uncertain significance Single submitter
- CXCR1 p.Leu92Phe Uncertain significance Single submitter
- CXCR1 p.Lys111Arg Uncertain significance Single submitter
- CXCR1 p.Lys111Glu Uncertain significance Single submitter
- CXCR1 p.Met268Lys Uncertain significance Single submitter
- CXCR1 p.Met61Ile Uncertain significance Single submitter
- CXCR1 p.Phe312Ser Uncertain significance Single submitter
- CXCR1 p.Pro170Arg Uncertain significance Single submitter
- CXCR1 p.Pro21Ser Uncertain significance Single submitter
- CXCR1 p.Pro22Ser Uncertain significance Single submitter
- CXCR1 p.Pro29Thr Uncertain significance Single submitter
- CXCR1 p.Ser132Asn Uncertain significance Single submitter
- CXCR1 p.Ser164Cys Uncertain significance Single submitter
- CXCR1 p.Thr107Ile Uncertain significance Single submitter
- CXCR1 p.Thr34Ile Uncertain significance Single submitter
- CXCR1 p.Tyr66Asn Uncertain significance Single submitter
- CXCR1 p.Tyr77Phe Uncertain significance Single submitter
- CXCR1 p.Val140Phe Uncertain significance Single submitter
- CXCR1 p.Val201Ala Uncertain significance Single submitter
- CXCR1 p.Val243Phe Uncertain significance Single submitter
- CXCR1 p.Val248Ile Uncertain significance Single submitter
- CXCR1 p.Val261Ile Uncertain significance Single submitter
- CXCR1 p.Arg227Ser Uncertain significance No assertion criteria
Predictors split 12
The independent predictors disagree with each other — read with care.
- CXCR1 p.Ser342Leu Benign Multiple submitters
- CXCR1 p.Ala177Gly Uncertain significance Single submitter
- CXCR1 p.Ala286Thr Uncertain significance Single submitter
- CXCR1 p.Asn16His Uncertain significance Single submitter
- CXCR1 p.Gly159Asp Uncertain significance Single submitter
- CXCR1 p.His233Tyr Uncertain significance Single submitter
- CXCR1 p.Ile292Thr Uncertain significance Single submitter
- CXCR1 p.Leu109Pro Uncertain significance Single submitter
- CXCR1 p.Phe211Leu Benign Single submitter
- CXCR1 p.Ser327Ile Uncertain significance Single submitter
- CXCR1 p.Ser53Asn Uncertain significance Single submitter
- CXCR1 p.Trp95Ser Uncertain significance Single submitter
All CXCR1 variants
Benign 3
- p.Ala96= Multiple submitters
- p.Ser342Leu Multiple submitters ⚠
- p.Phe211Leu Single submitter ⚠
Likely benign 9
- p.Arg279Cys Multiple submitters
- p.Ala23Thr Single submitter
- p.Arg313His Single submitter
- p.Lys149= Single submitter
- p.Ser72= Single submitter
- p.Val272Met Single submitter
- p.Arg239= No assertion criteria CXCR1-related disorder
- p.Lys154= No assertion criteria CXCR1-related disorder
- p.Tyr305= No assertion criteria CXCR1-related disorder
Uncertain significance 65
- p.Met1Ile Multiple submitters susceptibility to HIV infection
- p.Ala138Thr Single submitter
- p.Ala177Gly Single submitter ⚠
- p.Ala196Val Single submitter ⚠
- p.Ala286Thr Single submitter ⚠
- p.Ala97Ser Single submitter ⚠
- p.Ala97Thr Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg199Trp Single submitter ⚠
- p.Arg203Gln Single submitter susceptibility to HIV infection ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg227Cys Single submitter ⚠
- p.Arg279Pro Single submitter ⚠
- p.Arg280Cys Single submitter susceptibility to HIV infection ⚠
- p.Arg333Cys Single submitter ⚠
- p.Arg71His Single submitter ⚠
- p.Asn16His Single submitter ⚠
- p.Asn38Ile Single submitter ⚠
- p.Asn57Lys Single submitter ⚠
- p.Asp134Glu Single submitter ⚠
- p.Asp288Val Single submitter ⚠
- p.Asp85Asn Single submitter ⚠
- p.Cys187Phe Single submitter ⚠
- p.Glu275Asp Single submitter ⚠
- p.Gly159Asp Single submitter ⚠
- p.Gly19Val Single submitter ⚠
- p.Gly223Arg Single submitter ⚠
- p.Gly284Ser Single submitter ⚠
- p.His151Tyr Single submitter ⚠
- p.His207Asp Single submitter ⚠
- p.His233Tyr Single submitter ⚠
- p.His334Arg Single submitter ⚠
- p.Ile292Thr Single submitter ⚠
- p.Ile304Asn Single submitter ⚠
- p.Leu109Pro Single submitter ⚠
- p.Leu158Phe Single submitter ⚠
- p.Leu163Pro Single submitter ⚠
- p.Leu205Met Single submitter ⚠
- p.Leu293Pro Single submitter ⚠
- p.Leu86Pro Single submitter ⚠
- p.Leu92Phe Single submitter ⚠
- p.Lys111Arg Single submitter ⚠
- p.Lys111Glu Single submitter ⚠
- p.Met268Lys Single submitter ⚠
- p.Met61Ile Single submitter ⚠
- p.Phe312Ser Single submitter ⚠
- p.Pro170Arg Single submitter ⚠
- p.Pro21Ser Single submitter ⚠
- p.Pro22Ser Single submitter ⚠
- p.Pro29Thr Single submitter ⚠
- p.Ser132Asn Single submitter ⚠
- p.Ser164Cys Single submitter ⚠
- p.Ser327Ile Single submitter ⚠
- p.Ser53Asn Single submitter ⚠
- p.Thr107Ile Single submitter ⚠
- p.Thr34Ile Single submitter ⚠
- p.Trp95Ser Single submitter ⚠
- p.Tyr66Asn Single submitter ⚠
- p.Tyr77Phe Single submitter ⚠
- p.Val140Phe Single submitter ⚠
- p.Val201Ala Single submitter ⚠
- p.Val243Phe Single submitter ⚠
- p.Val248Ile Single submitter ⚠
- p.Val261Ile Single submitter ⚠
- p.Arg227Ser No assertion criteria ⚠