Sugi Variant

Sugi Variant/CXCR2

CXCR2 — 238 ClinVar variants

All ClinVar germline CXCR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 121 flagged for review →

5 Pathogenic · 2 Likely pathogenic · 3 Conflicting · 9 Benign · 3 Benign/Likely benign · 95 Likely benign · 121 Uncertain significance

Full CXCR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 121

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 97

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 20

The independent predictors disagree with each other — read with care.

All CXCR2 variants

Pathogenic 5

Likely pathogenic 2

Conflicting classifications of pathogenicity 3

Benign 9

Benign/Likely benign 3

Likely benign 95

Uncertain significance 121