CXCR3 — 42 ClinVar variants
All ClinVar germline CXCR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Conflicting · 1 Benign · 7 Likely benign · 33 Uncertain significance
Full CXCR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCR3 p.Ala114Asp Uncertain significance Single submitter
- CXCR3 p.Ala287Asp Uncertain significance Single submitter
- CXCR3 p.Ala73Thr Uncertain significance Single submitter
- CXCR3 p.Ala76Val Uncertain significance Single submitter
- CXCR3 p.Arg162Gly Uncertain significance Single submitter
- CXCR3 p.Arg212His Uncertain significance Single submitter
- CXCR3 p.Arg250His Uncertain significance Single submitter
- CXCR3 p.Asp52Asn Uncertain significance Single submitter
- CXCR3 p.Asp52Glu Uncertain significance Single submitter
- CXCR3 p.Gln219Arg Uncertain significance Single submitter
- CXCR3 p.Ile279Asn Uncertain significance Single submitter
- CXCR3 p.Leu123Phe Uncertain significance Single submitter
- CXCR3 p.Leu286Phe Uncertain significance Single submitter
- CXCR3 p.Leu85Pro Uncertain significance Single submitter
- CXCR3 p.Met309Leu Uncertain significance Single submitter
- CXCR3 p.Pro41Leu Uncertain significance Single submitter
- CXCR3 p.Ser191Leu Uncertain significance Single submitter
- CXCR3 p.Thr213Met Uncertain significance Single submitter
- CXCR3 p.Tyr160Ser Uncertain significance Single submitter
- CXCR3 p.Val221Ala Uncertain significance Single submitter
- CXCR3 p.Val274Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- CXCR3 p.Arg167Pro Uncertain significance Single submitter
- CXCR3 p.Arg212Cys Uncertain significance Single submitter
- CXCR3 p.Gly72Ser Uncertain significance Single submitter
- CXCR3 p.Lys324Asn Uncertain significance Single submitter
- CXCR3 p.Ser24Arg Uncertain significance Single submitter
- CXCR3 p.Thr201Ile Uncertain significance Single submitter
- CXCR3 p.Val168Met Uncertain significance Single submitter
- CXCR3 p.Val77Met Uncertain significance Single submitter
All CXCR3 variants
Conflicting classifications of pathogenicity 1
- p.Trp330Cys Single submitter ⚠
Benign 1
- c.13-31A>T Multiple submitters
Likely benign 7
- c.13-107T>C Single submitter
- p.Ala84= Single submitter
- p.Arg292Gln Single submitter
- p.His237= Single submitter
- p.Ser191= Single submitter
- p.Thr100Ala Single submitter
- p.Val16Phe Single submitter
Uncertain significance 33
- c.13-102G>A Single submitter
- c.13-122T>C Single submitter
- c.13-50T>C Single submitter
- c.13-75A>G Single submitter
- p.Ala114Asp Single submitter ⚠
- p.Ala287Asp Single submitter ⚠
- p.Ala73Thr Single submitter ⚠
- p.Ala76Val Single submitter ⚠
- p.Arg162Gly Single submitter ⚠
- p.Arg167Pro Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg212His Single submitter ⚠
- p.Arg250His Single submitter ⚠
- p.Asp52Asn Single submitter ⚠
- p.Asp52Glu Single submitter ⚠
- p.Gln219Arg Single submitter ⚠
- p.Gly72Ser Single submitter ⚠
- p.Ile279Asn Single submitter ⚠
- p.Leu123Phe Single submitter ⚠
- p.Leu286Phe Single submitter ⚠
- p.Leu85Pro Single submitter ⚠
- p.Lys324Asn Single submitter ⚠
- p.Met309Leu Single submitter ⚠
- p.Pro41Leu Single submitter ⚠
- p.Ser191Leu Single submitter ⚠
- p.Ser24Arg Single submitter ⚠
- p.Thr201Ile Single submitter ⚠
- p.Thr213Met Single submitter ⚠
- p.Tyr160Ser Single submitter ⚠
- p.Val168Met Single submitter ⚠
- p.Val221Ala Single submitter ⚠
- p.Val274Leu Single submitter ⚠
- p.Val77Met Single submitter ⚠