CXCR6 — 32 ClinVar variants
All ClinVar germline CXCR6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Benign · 1 Benign/Likely benign · 2 Likely benign · 28 Uncertain significance
Full CXCR6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CXCR6 p.Ala221Thr Uncertain significance Single submitter
- CXCR6 p.Asn333Ser Uncertain significance Single submitter
- CXCR6 p.Asp323Glu Uncertain significance Single submitter
- CXCR6 p.Cys180Arg Uncertain significance Single submitter
- CXCR6 p.Glu94Gly Uncertain significance Single submitter
- CXCR6 p.Gly107Asp Uncertain significance Single submitter
- CXCR6 p.Gly313Glu Uncertain significance Single submitter
- CXCR6 p.Leu283Phe Uncertain significance Single submitter
- CXCR6 p.Leu34Pro Uncertain significance Single submitter
- CXCR6 p.Met263Thr Uncertain significance Single submitter
- CXCR6 p.Met37Thr Uncertain significance Single submitter
- CXCR6 p.Phe328Ser Uncertain significance Single submitter
- CXCR6 p.Phe58Val Uncertain significance Single submitter
- CXCR6 p.Phe80Ser Uncertain significance Single submitter
- CXCR6 p.Val191Leu Uncertain significance Single submitter
- CXCR6 p.Val209Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CXCR6 p.Arg127His Uncertain significance Single submitter
- CXCR6 p.Arg254Cys Uncertain significance Single submitter
- CXCR6 p.Asp9Ala Uncertain significance Single submitter
- CXCR6 p.Gly107Arg Uncertain significance Single submitter
- CXCR6 p.Ile111Thr Uncertain significance Single submitter
- CXCR6 p.Ile129Thr Uncertain significance Single submitter
- CXCR6 p.Met263Ile Uncertain significance Single submitter
- CXCR6 p.Met37Arg Uncertain significance Single submitter
- CXCR6 p.Phe29Ile Uncertain significance Single submitter
- CXCR6 p.Thr337Pro Uncertain significance Single submitter
- CXCR6 p.Thr66Met Uncertain significance Single submitter
- CXCR6 p.Val209Ala Uncertain significance Single submitter
All CXCR6 variants
Benign 1
- p.Phe234= Multiple submitters
Benign/Likely benign 1
- p.Asp184= Multiple submitters
Likely benign 2
- p.Asp77= Multiple submitters
- p.Ile158Val Single submitter
Uncertain significance 28
- p.Ala221Thr Single submitter ⚠
- p.Arg127His Single submitter ⚠
- p.Arg254Cys Single submitter ⚠
- p.Asn333Ser Single submitter ⚠
- p.Asp323Glu Single submitter ⚠
- p.Asp9Ala Single submitter ⚠
- p.Cys180Arg Single submitter ⚠
- p.Glu94Gly Single submitter ⚠
- p.Gly107Arg Single submitter ⚠
- p.Gly107Asp Single submitter ⚠
- p.Gly313Glu Single submitter ⚠
- p.Ile111Thr Single submitter ⚠
- p.Ile129Thr Single submitter ⚠
- p.Leu283Phe Single submitter ⚠
- p.Leu34Pro Single submitter ⚠
- p.Met263Ile Single submitter ⚠
- p.Met263Thr Single submitter ⚠
- p.Met37Arg Single submitter ⚠
- p.Met37Thr Single submitter ⚠
- p.Phe29Ile Single submitter ⚠
- p.Phe328Ser Single submitter ⚠
- p.Phe58Val Single submitter ⚠
- p.Phe80Ser Single submitter ⚠
- p.Thr337Pro Single submitter ⚠
- p.Thr66Met Single submitter ⚠
- p.Val191Leu Single submitter ⚠
- p.Val209Ala Single submitter ⚠
- p.Val209Ile Single submitter ⚠