Sugi Variant

Sugi Variant/CYBC1

CYBC1 — 184 ClinVar variants

All ClinVar germline CYBC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →

3 Pathogenic · 2 Likely pathogenic · 3 Conflicting · 14 Benign · 8 Benign/Likely benign · 94 Likely benign · 60 Uncertain significance

Full CYBC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 48

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 32

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 15

The independent predictors disagree with each other — read with care.

All CYBC1 variants

Pathogenic 3

Likely pathogenic 2

Conflicting classifications of pathogenicity 3

Benign 14

Benign/Likely benign 8

Likely benign 94

Uncertain significance 60