CYGB — 34 ClinVar variants
All ClinVar germline CYGB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
2 Benign · 1 Likely benign · 31 Uncertain significance
Full CYGB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYGB p.Ala107Thr Uncertain significance Single submitter
- CYGB p.Arg15Gln Uncertain significance Single submitter
- CYGB p.Arg15Gly Uncertain significance Single submitter
- CYGB p.Arg74Gln Uncertain significance Single submitter
- CYGB p.Arg84Gln Uncertain significance Single submitter
- CYGB p.Gly6Ser Uncertain significance Single submitter
- CYGB p.Ile10Val Uncertain significance Single submitter
- CYGB p.Ile126Phe Uncertain significance Single submitter
- CYGB p.Leu115Pro Uncertain significance Single submitter
- CYGB p.Leu157Phe Uncertain significance Single submitter
- CYGB p.Met8Ile Uncertain significance Single submitter
- CYGB p.Pro181Ser Uncertain significance Single submitter
- CYGB p.Pro182Gln Uncertain significance Single submitter
- CYGB p.Pro186Thr Uncertain significance Single submitter
- CYGB p.Thr147Met Uncertain significance Single submitter
- CYGB p.Thr179Ala Uncertain significance Single submitter
- CYGB p.Val102Ala Uncertain significance Single submitter
- CYGB p.Val93Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CYGB p.Arg12Leu Uncertain significance Single submitter
- CYGB p.Arg155Cys Uncertain significance Single submitter
- CYGB p.Arg155His Uncertain significance Single submitter
- CYGB p.Arg79Trp Uncertain significance Single submitter
- CYGB p.Asp68Asn Uncertain significance Single submitter
- CYGB p.Asp68Glu Likely benign Single submitter
- CYGB p.Gln58Lys Uncertain significance Single submitter
- CYGB p.Gln77Arg Uncertain significance Single submitter
- CYGB p.Glu137Lys Uncertain significance Single submitter
- CYGB p.Lys101Arg Uncertain significance Single submitter
- CYGB p.Pro144Leu Uncertain significance Single submitter
- CYGB p.Ser104Cys Uncertain significance Single submitter
- CYGB p.Ser55Leu Uncertain significance Single submitter
- CYGB p.Val85Ile Uncertain significance Single submitter
All CYGB variants
Likely benign 1
- p.Asp68Glu Single submitter ⚠
Uncertain significance 31
- p.Ala107Thr Single submitter ⚠
- p.Arg12Leu Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg155His Single submitter ⚠
- p.Arg15Gln Single submitter ⚠
- p.Arg15Gly Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Arg79Trp Single submitter ⚠
- p.Arg84Gln Single submitter ⚠
- p.Asp68Asn Single submitter ⚠
- p.Gln58Lys Single submitter ⚠
- p.Gln77Arg Single submitter ⚠
- p.Glu137Lys Single submitter ⚠
- p.Gly6Ser Single submitter ⚠
- p.Ile10Val Single submitter ⚠
- p.Ile126Phe Single submitter ⚠
- p.Leu115Pro Single submitter ⚠
- p.Leu157Phe Single submitter ⚠
- p.Lys101Arg Single submitter ⚠
- p.Met8Ile Single submitter ⚠
- p.Pro144Leu Single submitter ⚠
- p.Pro181Ser Single submitter ⚠
- p.Pro182Gln Single submitter ⚠
- p.Pro186Thr Single submitter ⚠
- p.Ser104Cys Single submitter ⚠
- p.Ser55Leu Single submitter ⚠
- p.Thr147Met Single submitter ⚠
- p.Thr179Ala Single submitter ⚠
- p.Val102Ala Single submitter ⚠
- p.Val85Ile Single submitter ⚠
- p.Val93Met Single submitter ⚠