CYLC1 — 77 ClinVar variants
All ClinVar germline CYLC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Conflicting · 8 Likely benign · 68 Uncertain significance
Full CYLC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYLC1 p.Ala554Ser Uncertain significance Single submitter
- CYLC1 p.Ala595Val Uncertain significance Single submitter
- CYLC1 p.Ala611Asp Uncertain significance Single submitter
- CYLC1 p.Arg623His Uncertain significance Single submitter
- CYLC1 p.Asn156Asp Uncertain significance Single submitter
- CYLC1 p.Asp525Asn Uncertain significance Single submitter
- CYLC1 p.Asp525Val Uncertain significance Single submitter
- CYLC1 p.Asp542Glu Uncertain significance Single submitter
- CYLC1 p.Asp62Val Uncertain significance Single submitter
- CYLC1 p.Cys612Tyr Uncertain significance Single submitter
- CYLC1 p.Gln155Glu Uncertain significance Single submitter
- CYLC1 p.Gln253Arg Uncertain significance Single submitter
- CYLC1 p.Glu67Gly Uncertain significance Single submitter
- CYLC1 p.Glu67Lys Uncertain significance Single submitter
- CYLC1 p.Gly136Asp Uncertain significance Single submitter
- CYLC1 p.Gly504Val Uncertain significance Single submitter
- CYLC1 p.Gly531Ser Uncertain significance Single submitter
- CYLC1 p.Gly598Ser Uncertain significance Single submitter
- CYLC1 p.His215Arg Uncertain significance Single submitter
- CYLC1 p.His498Arg Uncertain significance Single submitter
- CYLC1 p.His61Tyr Uncertain significance Single submitter
- CYLC1 p.Ile77Met Uncertain significance Single submitter
- CYLC1 p.Leu573Pro Uncertain significance Single submitter
- CYLC1 p.Lys129Asn Uncertain significance Single submitter
- CYLC1 p.Lys198Asn Uncertain significance Single submitter
- CYLC1 p.Lys456Asn Uncertain significance Single submitter
- CYLC1 p.Met581Ile Uncertain significance Single submitter
- CYLC1 p.Pro142Ser Uncertain significance Single submitter
- CYLC1 p.Pro162Ser Uncertain significance Single submitter
- CYLC1 p.Pro220Ser Uncertain significance Single submitter
- CYLC1 p.Pro233Leu Uncertain significance Single submitter
- CYLC1 p.Pro367Thr Uncertain significance Single submitter
- CYLC1 p.Pro89His Uncertain significance Single submitter
- CYLC1 p.Pro89Leu Uncertain significance Single submitter
- CYLC1 p.Ser535Thr Uncertain significance Single submitter
- CYLC1 p.Thr92Ala Uncertain significance Single submitter
- CYLC1 p.Val148Ala Uncertain significance Single submitter
- CYLC1 p.Val317Ile Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- CYLC1 p.Arg344Met Uncertain significance Single submitter
- CYLC1 p.Arg637Ser Uncertain significance Single submitter
- CYLC1 p.Asn194Ser Uncertain significance Single submitter
- CYLC1 p.Asp199Tyr Uncertain significance Single submitter
- CYLC1 p.Asp305Tyr Uncertain significance Single submitter
- CYLC1 p.Asp309His Uncertain significance Single submitter
- CYLC1 p.Asp325Gly Uncertain significance Single submitter
- CYLC1 p.Asp342Tyr Uncertain significance Single submitter
- CYLC1 p.Asp358Gly Uncertain significance Single submitter
- CYLC1 p.Asp471Tyr Uncertain significance Single submitter
- CYLC1 p.Asp489Asn Uncertain significance Single submitter
- CYLC1 p.Asp512His Uncertain significance Single submitter
- CYLC1 p.Gly457Arg Uncertain significance Single submitter
- CYLC1 p.Lys274Asn Uncertain significance Single submitter
- CYLC1 p.Lys274Glu Uncertain significance Single submitter
- CYLC1 p.Lys307Asn Uncertain significance Single submitter
- CYLC1 p.Lys308Arg Uncertain significance Single submitter
- CYLC1 p.Lys402Thr Uncertain significance Single submitter
- CYLC1 p.Lys434Thr Uncertain significance Single submitter
- CYLC1 p.Lys435Asn Uncertain significance Single submitter
- CYLC1 p.Lys503Arg Uncertain significance Single submitter
- CYLC1 p.Pro631Ser Uncertain significance Single submitter
- CYLC1 p.Pro636Gln Uncertain significance Single submitter
- CYLC1 p.Ser118Phe Uncertain significance Single submitter
- CYLC1 p.Ser192Leu Uncertain significance Single submitter
- CYLC1 p.Ser196Thr Uncertain significance Single submitter
- CYLC1 p.Ser277Tyr Uncertain significance Single submitter
- CYLC1 p.Ser519Thr Uncertain significance Single submitter
- CYLC1 p.Ser596Asn Uncertain significance Single submitter
- CYLC1 p.Thr209Ile Uncertain significance Single submitter
All CYLC1 variants
Conflicting classifications of pathogenicity 1
- p.Gln42Lys Single submitter ⚠
Likely benign 8
- c.17+4A>G Single submitter
- p.Asn382Lys Single submitter
- p.His32= Single submitter
- p.Ile147= Single submitter
- p.Leu41Pro Single submitter
- p.Lys304= Single submitter
- p.Pro233Ser Single submitter
- p.Ser273= Single submitter
Uncertain significance 68
- p.Ala554Ser Single submitter ⚠
- p.Ala595Val Single submitter ⚠
- p.Ala611Asp Single submitter ⚠
- p.Arg344Met Single submitter ⚠
- p.Arg623His Single submitter ⚠
- p.Arg637Ser Single submitter ⚠
- p.Asn156Asp Single submitter ⚠
- p.Asn194Ser Single submitter ⚠
- p.Asp199Tyr Single submitter ⚠
- p.Asp305Tyr Single submitter ⚠
- p.Asp309His Single submitter ⚠
- p.Asp325Gly Single submitter ⚠
- p.Asp342Tyr Single submitter ⚠
- p.Asp358Gly Single submitter ⚠
- p.Asp471Tyr Single submitter ⚠
- p.Asp489Asn Single submitter ⚠
- p.Asp512His Single submitter ⚠
- p.Asp525Asn Single submitter ⚠
- p.Asp525Val Single submitter ⚠
- p.Asp542Glu Single submitter ⚠
- p.Asp62Val Single submitter ⚠
- p.Cys612Tyr Single submitter ⚠
- p.Gln155Glu Single submitter ⚠
- p.Gln253Arg Single submitter ⚠
- p.Glu67Gly Single submitter ⚠
- p.Glu67Lys Single submitter ⚠
- p.Gly136Asp Single submitter ⚠
- p.Gly457Arg Single submitter ⚠
- p.Gly504Val Single submitter ⚠
- p.Gly531Ser Single submitter ⚠
- p.Gly598Ser Single submitter ⚠
- p.His215Arg Single submitter ⚠
- p.His498Arg Single submitter ⚠
- p.His61Tyr Single submitter ⚠
- p.Ile77Met Single submitter ⚠
- p.Leu573Pro Single submitter ⚠
- p.Lys129Asn Single submitter ⚠
- p.Lys198Asn Single submitter ⚠
- p.Lys274Asn Single submitter ⚠
- p.Lys274Glu Single submitter ⚠
- p.Lys307Asn Single submitter ⚠
- p.Lys308Arg Single submitter ⚠
- p.Lys402Thr Single submitter ⚠
- p.Lys434Thr Single submitter ⚠
- p.Lys435Asn Single submitter ⚠
- p.Lys456Asn Single submitter ⚠
- p.Lys503Arg Single submitter ⚠
- p.Met581Ile Single submitter ⚠
- p.Pro142Ser Single submitter ⚠
- p.Pro162Ser Single submitter ⚠
- p.Pro220Ser Single submitter ⚠
- p.Pro233Leu Single submitter ⚠
- p.Pro367Thr Single submitter ⚠
- p.Pro631Ser Single submitter ⚠
- p.Pro636Gln Single submitter ⚠
- p.Pro89His Single submitter ⚠
- p.Pro89Leu Single submitter ⚠
- p.Ser118Phe Single submitter ⚠
- p.Ser192Leu Single submitter ⚠
- p.Ser196Thr Single submitter ⚠
- p.Ser277Tyr Single submitter ⚠
- p.Ser519Thr Single submitter ⚠
- p.Ser535Thr Single submitter ⚠
- p.Ser596Asn Single submitter ⚠
- p.Thr209Ile Single submitter ⚠
- p.Thr92Ala Single submitter ⚠
- p.Val148Ala Single submitter ⚠
- p.Val317Ile Single submitter ⚠