CYLC2 — 69 ClinVar variants
All ClinVar germline CYLC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
8 Likely benign · 61 Uncertain significance
Full CYLC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYLC2 p.Ala296Thr Uncertain significance Single submitter
- CYLC2 p.Ala327Glu Uncertain significance Single submitter
- CYLC2 p.Arg55Gln Uncertain significance Single submitter
- CYLC2 p.Arg55Trp Uncertain significance Single submitter
- CYLC2 p.Arg71Gly Uncertain significance Single submitter
- CYLC2 p.Arg83Gly Uncertain significance Single submitter
- CYLC2 p.Asp156Glu Uncertain significance Single submitter
- CYLC2 p.Asp240Ala Uncertain significance Single submitter
- CYLC2 p.Asp244Glu Uncertain significance Single submitter
- CYLC2 p.Asp63Gly Uncertain significance Single submitter
- CYLC2 p.Gly254Ser Uncertain significance Single submitter
- CYLC2 p.Gly347Asp Uncertain significance Single submitter
- CYLC2 p.Ile114Thr Uncertain significance Single submitter
- CYLC2 p.Ile62Thr Uncertain significance Single submitter
- CYLC2 p.Thr297Arg Uncertain significance Single submitter
- CYLC2 p.Thr308Ala Uncertain significance Single submitter
- CYLC2 p.Val237Ile Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- CYLC2 p.Asp330His Uncertain significance Multiple submitters
- CYLC2 p.Ala175Val Uncertain significance Single submitter
- CYLC2 p.Ala331Glu Likely benign Single submitter
- CYLC2 p.Arg42Gln Uncertain significance Single submitter
- CYLC2 p.Arg95Thr Uncertain significance Single submitter
- CYLC2 p.Asn252His Uncertain significance Single submitter
- CYLC2 p.Asp140Tyr Uncertain significance Single submitter
- CYLC2 p.Asp146Gly Uncertain significance Single submitter
- CYLC2 p.Asp201His Uncertain significance Single submitter
- CYLC2 p.Asp223Tyr Uncertain significance Single submitter
- CYLC2 p.Asp244His Uncertain significance Single submitter
- CYLC2 p.Asp286His Uncertain significance Single submitter
- CYLC2 p.Asp287Gly Uncertain significance Single submitter
- CYLC2 p.Asp318Val Uncertain significance Single submitter
- CYLC2 p.Asp330Tyr Uncertain significance Single submitter
- CYLC2 p.Glu311Lys Uncertain significance Single submitter
- CYLC2 p.Gly144Asp Uncertain significance Single submitter
- CYLC2 p.Gly199Val Uncertain significance Single submitter
- CYLC2 p.Gly220Cys Uncertain significance Single submitter
- CYLC2 p.Lys158Glu Uncertain significance Single submitter
- CYLC2 p.Lys191Arg Uncertain significance Single submitter
- CYLC2 p.Lys221Glu Uncertain significance Single submitter
- CYLC2 p.Lys222Arg Uncertain significance Single submitter
- CYLC2 p.Lys243Arg Uncertain significance Single submitter
- CYLC2 p.Lys248Ile Uncertain significance Single submitter
- CYLC2 p.Lys271Asn Uncertain significance Single submitter
- CYLC2 p.Lys272Glu Uncertain significance Single submitter
- CYLC2 p.Lys302Thr Uncertain significance Single submitter
- CYLC2 p.Lys316Asn Uncertain significance Single submitter
- CYLC2 p.Lys328Arg Uncertain significance Single submitter
- CYLC2 p.Lys328Glu Uncertain significance Single submitter
- CYLC2 p.Pro19Thr Uncertain significance Single submitter
- CYLC2 p.Pro40Ser Uncertain significance Single submitter
- CYLC2 p.Pro43Ser Uncertain significance Single submitter
- CYLC2 p.Pro74Gln Uncertain significance Single submitter
- CYLC2 p.Pro74Ser Uncertain significance Single submitter
- CYLC2 p.Pro88Gln Uncertain significance Single submitter
- CYLC2 p.Ser161Gly Uncertain significance Single submitter
- CYLC2 p.Ser202Leu Uncertain significance Single submitter
- CYLC2 p.Ser206Phe Uncertain significance Single submitter
- CYLC2 p.Ser230Leu Uncertain significance Single submitter
- CYLC2 p.Ser257Leu Uncertain significance Single submitter
- CYLC2 p.Thr297Met Uncertain significance Single submitter
- CYLC2 p.Thr58Met Uncertain significance Single submitter
- CYLC2 p.Trp28Arg Uncertain significance Single submitter
All CYLC2 variants
Likely benign 8
- p.Ala331Glu Single submitter ⚠
- p.Ala34Ser Single submitter
- p.Arg71His Single submitter
- p.Asn334Asp Single submitter
- p.Glu106Lys Single submitter
- p.Glu65= Single submitter
- p.Val303Asp Single submitter
- p.Glu309Lys No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 61
- p.Asp330His Multiple submitters ⚠
- p.Ala175Val Single submitter ⚠
- p.Ala296Thr Single submitter ⚠
- p.Ala327Glu Single submitter ⚠
- p.Arg42Gln Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg55Trp Single submitter ⚠
- p.Arg71Gly Single submitter ⚠
- p.Arg83Gly Single submitter ⚠
- p.Arg95Thr Single submitter ⚠
- p.Asn252His Single submitter ⚠
- p.Asp140Tyr Single submitter ⚠
- p.Asp146Gly Single submitter ⚠
- p.Asp156Glu Single submitter ⚠
- p.Asp201His Single submitter ⚠
- p.Asp223Tyr Single submitter ⚠
- p.Asp240Ala Single submitter ⚠
- p.Asp244Glu Single submitter ⚠
- p.Asp244His Single submitter ⚠
- p.Asp286His Single submitter ⚠
- p.Asp287Gly Single submitter ⚠
- p.Asp318Val Single submitter ⚠
- p.Asp330Tyr Single submitter ⚠
- p.Asp63Gly Single submitter ⚠
- p.Glu311Lys Single submitter ⚠
- p.Gly144Asp Single submitter ⚠
- p.Gly199Val Single submitter ⚠
- p.Gly220Cys Single submitter ⚠
- p.Gly254Ser Single submitter ⚠
- p.Gly347Asp Single submitter ⚠
- p.Ile114Thr Single submitter ⚠
- p.Ile62Thr Single submitter ⚠
- p.Lys158Glu Single submitter ⚠
- p.Lys191Arg Single submitter ⚠
- p.Lys221Glu Single submitter ⚠
- p.Lys222Arg Single submitter ⚠
- p.Lys243Arg Single submitter ⚠
- p.Lys248Ile Single submitter ⚠
- p.Lys271Asn Single submitter ⚠
- p.Lys272Glu Single submitter ⚠
- p.Lys302Thr Single submitter ⚠
- p.Lys316Asn Single submitter ⚠
- p.Lys328Arg Single submitter ⚠
- p.Lys328Glu Single submitter ⚠
- p.Pro19Thr Single submitter ⚠
- p.Pro40Ser Single submitter ⚠
- p.Pro43Ser Single submitter ⚠
- p.Pro74Gln Single submitter ⚠
- p.Pro74Ser Single submitter ⚠
- p.Pro88Gln Single submitter ⚠
- p.Ser161Gly Single submitter ⚠
- p.Ser202Leu Single submitter ⚠
- p.Ser206Phe Single submitter ⚠
- p.Ser230Leu Single submitter ⚠
- p.Ser257Leu Single submitter ⚠
- p.Thr297Arg Single submitter ⚠
- p.Thr297Met Single submitter ⚠
- p.Thr308Ala Single submitter ⚠
- p.Thr58Met Single submitter ⚠
- p.Trp28Arg Single submitter ⚠
- p.Val237Ile Single submitter ⚠