CYP2C18 — 80 ClinVar variants
All ClinVar germline CYP2C18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
6 Benign · 9 Likely benign · 65 Uncertain significance
Full CYP2C18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP2C18 p.Met406Ile Uncertain significance Multiple submitters
- CYP2C18 p.Ala289Thr Uncertain significance Single submitter
- CYP2C18 p.Ala350Pro Uncertain significance Single submitter
- CYP2C18 p.Arg132Pro Uncertain significance Single submitter
- CYP2C18 p.Arg150Cys Uncertain significance Single submitter
- CYP2C18 p.Arg206Ser Uncertain significance Single submitter
- CYP2C18 p.Arg357Lys Uncertain significance Single submitter
- CYP2C18 p.Arg478Cys Uncertain significance Single submitter
- CYP2C18 p.Asn116Ser Uncertain significance Single submitter
- CYP2C18 p.Asn202Ser Uncertain significance Single submitter
- CYP2C18 p.Asp191Gly Uncertain significance Single submitter
- CYP2C18 p.Cys216Arg Uncertain significance Single submitter
- CYP2C18 p.Cys216Ser Uncertain significance Single submitter
- CYP2C18 p.Cys266Arg Uncertain significance Single submitter
- CYP2C18 p.Glu142Lys Uncertain significance Single submitter
- CYP2C18 p.Glu148Val Uncertain significance Single submitter
- CYP2C18 p.Glu235Asp Uncertain significance Single submitter
- CYP2C18 p.Glu246Lys Uncertain significance Single submitter
- CYP2C18 p.Glu354Lys Uncertain significance Single submitter
- CYP2C18 p.His353Arg Uncertain significance Single submitter
- CYP2C18 p.Ile169Thr Uncertain significance Single submitter
- CYP2C18 p.Ile178Thr Uncertain significance Single submitter
- CYP2C18 p.Ile359Thr Uncertain significance Single submitter
- CYP2C18 p.Leu197Met Uncertain significance Single submitter
- CYP2C18 p.Leu19His Uncertain significance Single submitter
- CYP2C18 p.Leu314Pro Uncertain significance Single submitter
- CYP2C18 p.Leu366Val Uncertain significance Single submitter
- CYP2C18 p.Lys138Asn Uncertain significance Single submitter
- CYP2C18 p.Lys241Arg Uncertain significance Single submitter
- CYP2C18 p.Lys249Arg Uncertain significance Single submitter
- CYP2C18 p.Lys275Asn Uncertain significance Single submitter
- CYP2C18 p.Met198Thr Uncertain significance Single submitter
- CYP2C18 p.Met257Val Uncertain significance Single submitter
- CYP2C18 p.Met271Ile Uncertain significance Single submitter
- CYP2C18 p.Met294Ile Uncertain significance Single submitter
- CYP2C18 p.Phe187Tyr Uncertain significance Single submitter
- CYP2C18 p.Phe407Tyr Uncertain significance Single submitter
- CYP2C18 p.Ser99Thr Uncertain significance Single submitter
- CYP2C18 p.Thr167Ile Uncertain significance Single submitter
- CYP2C18 p.Thr290Ala Uncertain significance Single submitter
- CYP2C18 p.Thr301Lys Uncertain significance Single submitter
- CYP2C18 p.Tyr243Ser Uncertain significance Single submitter
- CYP2C18 p.Tyr358His Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CYP2C18 p.Arg186Gln Uncertain significance Single submitter
- CYP2C18 p.Asn116Lys Uncertain significance Single submitter
- CYP2C18 p.Asn277Thr Uncertain significance Single submitter
- CYP2C18 p.Asp423Ala Uncertain significance Single submitter
- CYP2C18 p.Gln44Leu Uncertain significance Single submitter
- CYP2C18 p.Glu155Asp Uncertain significance Single submitter
- CYP2C18 p.Glu93Lys Likely benign Single submitter
- CYP2C18 p.Ile248Met Uncertain significance Single submitter
- CYP2C18 p.Lys108Thr Uncertain significance Single submitter
- CYP2C18 p.Met136Leu Uncertain significance Single submitter
- CYP2C18 p.Met136Val Uncertain significance Single submitter
- CYP2C18 p.Pro174Thr Uncertain significance Single submitter
- CYP2C18 p.Pro220Ser Uncertain significance Single submitter
- CYP2C18 p.Pro404Arg Uncertain significance Single submitter
- CYP2C18 p.Pro464Thr Uncertain significance Single submitter
- CYP2C18 p.Pro73Ser Uncertain significance Single submitter
- CYP2C18 p.Ser140Asn Uncertain significance Single submitter
- CYP2C18 p.Ser140Thr Uncertain significance Single submitter
- CYP2C18 p.Ser303Asn Uncertain significance Single submitter
- CYP2C18 p.Thr299Ile Benign Single submitter
- CYP2C18 p.Thr302Met Uncertain significance Single submitter
- CYP2C18 p.Val75Ala Uncertain significance Single submitter
All CYP2C18 variants
Benign 6
- p.Arg442Leu Single submitter
- p.Asp165= Single submitter
- p.Ile223= Single submitter
- p.Ser393= Single submitter
- p.Thr299Ile Single submitter ⚠
- p.Val330Leu Single submitter
Likely benign 9
- p.Arg261Gln Single submitter
- p.Asn258Asp Single submitter
- p.Glu93Lys Single submitter ⚠
- p.Ile240Val Single submitter
- p.Met198Leu Single submitter
- p.Met434Ile Single submitter
- p.Met50Ile Single submitter
- p.Ser209= Single submitter
- p.Ser460Pro Single submitter
Uncertain significance 65
- p.Met406Ile Multiple submitters ⚠
- p.Ala289Thr Single submitter ⚠
- p.Ala350Pro Single submitter ⚠
- p.Arg132Pro Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg206Ser Single submitter ⚠
- p.Arg357Lys Single submitter ⚠
- p.Arg478Cys Single submitter ⚠
- p.Asn116Lys Single submitter ⚠
- p.Asn116Ser Single submitter ⚠
- p.Asn202Ser Single submitter ⚠
- p.Asn277Thr Single submitter ⚠
- p.Asp191Gly Single submitter ⚠
- p.Asp423Ala Single submitter ⚠
- p.Cys216Arg Single submitter ⚠
- p.Cys216Ser Single submitter ⚠
- p.Cys266Arg Single submitter ⚠
- p.Gln44Leu Single submitter ⚠
- p.Glu142Lys Single submitter ⚠
- p.Glu148Val Single submitter ⚠
- p.Glu155Asp Single submitter ⚠
- p.Glu235Asp Single submitter ⚠
- p.Glu246Lys Single submitter ⚠
- p.Glu354Lys Single submitter ⚠
- p.His353Arg Single submitter ⚠
- p.Ile169Thr Single submitter ⚠
- p.Ile178Thr Single submitter ⚠
- p.Ile248Met Single submitter ⚠
- p.Ile359Thr Single submitter ⚠
- p.Ile381Met Single submitter
- p.Leu197Met Single submitter ⚠
- p.Leu19His Single submitter ⚠
- p.Leu314Pro Single submitter ⚠
- p.Leu366Val Single submitter ⚠
- p.Lys108Thr Single submitter ⚠
- p.Lys138Asn Single submitter ⚠
- p.Lys241Arg Single submitter ⚠
- p.Lys249Arg Single submitter ⚠
- p.Lys275Asn Single submitter ⚠
- p.Met136Leu Single submitter ⚠
- p.Met136Val Single submitter ⚠
- p.Met198Thr Single submitter ⚠
- p.Met257Val Single submitter ⚠
- p.Met271Ile Single submitter ⚠
- p.Met294Ile Single submitter ⚠
- p.Phe187Tyr Single submitter ⚠
- p.Phe407Tyr Single submitter ⚠
- p.Pro174Thr Single submitter ⚠
- p.Pro220Ser Single submitter ⚠
- p.Pro367Leu Single submitter
- p.Pro404Arg Single submitter ⚠
- p.Pro464Thr Single submitter ⚠
- p.Pro73Ser Single submitter ⚠
- p.Ser140Asn Single submitter ⚠
- p.Ser140Thr Single submitter ⚠
- p.Ser303Asn Single submitter ⚠
- p.Ser99Thr Single submitter ⚠
- p.Thr167Ile Single submitter ⚠
- p.Thr290Ala Single submitter ⚠
- p.Thr301Lys Single submitter ⚠
- p.Thr302Met Single submitter ⚠
- p.Tyr243Ser Single submitter ⚠
- p.Tyr358His Single submitter ⚠
- p.Val75Ala Single submitter ⚠