CYP2F1 — 97 ClinVar variants
All ClinVar germline CYP2F1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →
8 Benign · 5 Likely benign · 84 Uncertain significance
Full CYP2F1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 87
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP2F1 p.Ala114Thr Uncertain significance Single submitter
- CYP2F1 p.Ala14Val Uncertain significance Single submitter
- CYP2F1 p.Ala339Thr Uncertain significance Single submitter
- CYP2F1 p.Ala351Val Uncertain significance Single submitter
- CYP2F1 p.Ala360Gly Uncertain significance Single submitter
- CYP2F1 p.Ala452Thr Uncertain significance Single submitter
- CYP2F1 p.Ala464Val Uncertain significance Single submitter
- CYP2F1 p.Arg145Gln Uncertain significance Single submitter
- CYP2F1 p.Arg158Gln Uncertain significance Single submitter
- CYP2F1 p.Arg482Gln Uncertain significance Single submitter
- CYP2F1 p.Arg489Cys Uncertain significance Single submitter
- CYP2F1 p.Asn106Ser Uncertain significance Single submitter
- CYP2F1 p.Asp225Asn Uncertain significance Single submitter
- CYP2F1 p.Asp263Asn Uncertain significance Single submitter
- CYP2F1 p.Asp50His Uncertain significance Single submitter
- CYP2F1 p.Cys180Arg Uncertain significance Single submitter
- CYP2F1 p.Gln207Lys Uncertain significance Single submitter
- CYP2F1 p.Gln418Glu Uncertain significance Single submitter
- CYP2F1 p.Glu215Lys Uncertain significance Single submitter
- CYP2F1 p.Ile468Met Uncertain significance Single submitter
- CYP2F1 p.Ile8Val Uncertain significance Single submitter
- CYP2F1 p.Met444Ile Uncertain significance Single submitter
- CYP2F1 p.Met51Ile Uncertain significance Single submitter
- CYP2F1 p.Phe408Leu Uncertain significance Single submitter
- CYP2F1 p.Phe95Leu Uncertain significance Single submitter
- CYP2F1 p.Pro102Ser Uncertain significance Single submitter
- CYP2F1 p.Val16Ile Uncertain significance Single submitter
Predictors split 60
The independent predictors disagree with each other — read with care.
- CYP2F1 p.Leu391Pro Benign Multiple submitters
- CYP2F1 p.Val175Gly Benign Multiple submitters
- CYP2F1 p.Val175Leu Benign Multiple submitters
- CYP2F1 p.Ala310Thr Uncertain significance Single submitter
- CYP2F1 p.Ala351Thr Uncertain significance Single submitter
- CYP2F1 p.Arg120Gln Uncertain significance Single submitter
- CYP2F1 p.Arg262Trp Uncertain significance Single submitter
- CYP2F1 p.Arg378Cys Uncertain significance Single submitter
- CYP2F1 p.Arg433Cys Uncertain significance Single submitter
- CYP2F1 p.Arg443Cys Uncertain significance Single submitter
- CYP2F1 p.Arg491His Uncertain significance Single submitter
- CYP2F1 p.Arg74Gln Uncertain significance Single submitter
- CYP2F1 p.Asn203Lys Uncertain significance Single submitter
- CYP2F1 p.Asn237Ile Uncertain significance Single submitter
- CYP2F1 p.Asn417Ser Uncertain significance Single submitter
- CYP2F1 p.Asp398Asn Uncertain significance Single submitter
- CYP2F1 p.Asp415Asn Uncertain significance Single submitter
- CYP2F1 p.Asp467Tyr Uncertain significance Single submitter
- CYP2F1 p.Asp469Asn Uncertain significance Single submitter
- CYP2F1 p.Asp469His Uncertain significance Single submitter
- CYP2F1 p.Gln126Leu Uncertain significance Single submitter
- CYP2F1 p.Gln325His Uncertain significance Single submitter
- CYP2F1 p.Gln325Leu Uncertain significance Single submitter
- CYP2F1 p.Gln418Pro Uncertain significance Single submitter
- CYP2F1 p.Glu411Lys Uncertain significance Single submitter
- CYP2F1 p.Glu439Gly Uncertain significance Single submitter
- CYP2F1 p.Gly136Val Uncertain significance Single submitter
- CYP2F1 p.Gly214Ser Uncertain significance Single submitter
- CYP2F1 p.Gly299Cys Uncertain significance Single submitter
- CYP2F1 p.Gly80Arg Uncertain significance Single submitter
- CYP2F1 p.Ile129Asn Uncertain significance Single submitter
- CYP2F1 p.Ile142Thr Uncertain significance Single submitter
- CYP2F1 p.Leu196Phe Uncertain significance Single submitter
- CYP2F1 p.Leu441Met Uncertain significance Single submitter
- CYP2F1 p.Leu459Gln Uncertain significance Single submitter
- CYP2F1 p.Leu55Phe Uncertain significance Single submitter
- CYP2F1 p.Met137Leu Uncertain significance Single submitter
- CYP2F1 p.Met427Val Uncertain significance Single submitter
- CYP2F1 p.Phe264Leu Uncertain significance Single submitter
- CYP2F1 p.Pro338Leu Uncertain significance Single submitter
- CYP2F1 p.Pro405Leu Uncertain significance Single submitter
- CYP2F1 p.Pro405Ser Uncertain significance Single submitter
- CYP2F1 p.Pro461Leu Uncertain significance Single submitter
- CYP2F1 p.Pro481Leu Uncertain significance Single submitter
- CYP2F1 p.Ser117Gly Uncertain significance Single submitter
- CYP2F1 p.Ser128Ala Uncertain significance Single submitter
- CYP2F1 p.Ser255Leu Uncertain significance Single submitter
- CYP2F1 p.Ser3Gly Uncertain significance Single submitter
- CYP2F1 p.Ser400Cys Uncertain significance Single submitter
- CYP2F1 p.Ser440Leu Uncertain significance Single submitter
- CYP2F1 p.Ser48Phe Uncertain significance Single submitter
- CYP2F1 p.Ser5Asn Uncertain significance Single submitter
- CYP2F1 p.Ser5Cys Uncertain significance Single submitter
- CYP2F1 p.Thr168Lys Uncertain significance Single submitter
- CYP2F1 p.Thr291Ala Uncertain significance Single submitter
- CYP2F1 p.Thr306Met Uncertain significance Single submitter
- CYP2F1 p.Thr404Met Uncertain significance Single submitter
- CYP2F1 p.Tyr217Cys Uncertain significance Single submitter
- CYP2F1 p.Val356Met Uncertain significance Single submitter
- CYP2F1 p.Val395Ile Uncertain significance Single submitter
All CYP2F1 variants
Benign 8
- c.335-8C>G Multiple submitters
- p.Arg370= Multiple submitters
- p.Arg98Pro Multiple submitters
- p.Gln266His Multiple submitters
- p.Leu391Pro Multiple submitters ⚠
- p.Val175Gly Multiple submitters ⚠
- p.Val175Leu Multiple submitters ⚠
- p.Thr6fs Single submitter
Likely benign 5
- p.Gln126Arg Single submitter
- p.Glu61Lys Single submitter
- p.Lys301Glu Single submitter
- p.Thr386= Single submitter
- c.1152+4C>A No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 84
- p.Ala114Thr Single submitter ⚠
- p.Ala14Val Single submitter ⚠
- p.Ala310Thr Single submitter ⚠
- p.Ala339Thr Single submitter ⚠
- p.Ala351Thr Single submitter ⚠
- p.Ala351Val Single submitter ⚠
- p.Ala360Gly Single submitter ⚠
- p.Ala452Thr Single submitter ⚠
- p.Ala464Val Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg145Gln Single submitter ⚠
- p.Arg158Gln Single submitter ⚠
- p.Arg262Trp Single submitter ⚠
- p.Arg378Cys Single submitter ⚠
- p.Arg433Cys Single submitter ⚠
- p.Arg443Cys Single submitter ⚠
- p.Arg482Gln Single submitter ⚠
- p.Arg489Cys Single submitter ⚠
- p.Arg491His Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Asn106Ser Single submitter ⚠
- p.Asn203Lys Single submitter ⚠
- p.Asn237Ile Single submitter ⚠
- p.Asn417Ser Single submitter ⚠
- p.Asp225Asn Single submitter ⚠
- p.Asp263Asn Single submitter ⚠
- p.Asp398Asn Single submitter ⚠
- p.Asp415Asn Single submitter ⚠
- p.Asp467Tyr Single submitter ⚠
- p.Asp469Asn Single submitter ⚠
- p.Asp469His Single submitter ⚠
- p.Asp50His Single submitter ⚠
- p.Cys180Arg Single submitter ⚠
- p.Gln126Leu Single submitter ⚠
- p.Gln207Lys Single submitter ⚠
- p.Gln325His Single submitter ⚠
- p.Gln325Leu Single submitter ⚠
- p.Gln418Glu Single submitter ⚠
- p.Gln418Pro Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu411Lys Single submitter ⚠
- p.Glu439Gly Single submitter ⚠
- p.Gly136Val Single submitter ⚠
- p.Gly214Ser Single submitter ⚠
- p.Gly299Cys Single submitter ⚠
- p.Gly80Arg Single submitter ⚠
- p.Ile129Asn Single submitter ⚠
- p.Ile142Thr Single submitter ⚠
- p.Ile468Met Single submitter ⚠
- p.Ile8Val Single submitter ⚠
- p.Leu196Phe Single submitter ⚠
- p.Leu441Met Single submitter ⚠
- p.Leu459Gln Single submitter ⚠
- p.Leu55Phe Single submitter ⚠
- p.Met137Leu Single submitter ⚠
- p.Met427Val Single submitter ⚠
- p.Met444Ile Single submitter ⚠
- p.Met51Ile Single submitter ⚠
- p.Phe264Leu Single submitter ⚠
- p.Phe408Leu Single submitter ⚠
- p.Phe95Leu Single submitter ⚠
- p.Pro102Ser Single submitter ⚠
- p.Pro338Leu Single submitter ⚠
- p.Pro405Leu Single submitter ⚠
- p.Pro405Ser Single submitter ⚠
- p.Pro461Leu Single submitter ⚠
- p.Pro481Leu Single submitter ⚠
- p.Ser117Gly Single submitter ⚠
- p.Ser128Ala Single submitter ⚠
- p.Ser255Leu Single submitter ⚠
- p.Ser3Gly Single submitter ⚠
- p.Ser400Cys Single submitter ⚠
- p.Ser440Leu Single submitter ⚠
- p.Ser48Phe Single submitter ⚠
- p.Ser5Asn Single submitter ⚠
- p.Ser5Cys Single submitter ⚠
- p.Thr168Lys Single submitter ⚠
- p.Thr291Ala Single submitter ⚠
- p.Thr306Met Single submitter ⚠
- p.Thr404Met Single submitter ⚠
- p.Tyr217Cys Single submitter ⚠
- p.Val16Ile Single submitter ⚠
- p.Val356Met Single submitter ⚠
- p.Val395Ile Single submitter ⚠