CYP2J2 — 68 ClinVar variants
All ClinVar germline CYP2J2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
2 Benign · 3 Likely benign · 63 Uncertain significance
Full CYP2J2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP2J2 p.Ala133Thr Uncertain significance Single submitter
- CYP2J2 p.Ala14Pro Uncertain significance Single submitter
- CYP2J2 p.Ala4Glu Uncertain significance Single submitter
- CYP2J2 p.Ala9Ser Uncertain significance Single submitter
- CYP2J2 p.Asn476Lys Uncertain significance Single submitter
- CYP2J2 p.Asp279Glu Uncertain significance Single submitter
- CYP2J2 p.Asp85Asn Uncertain significance Single submitter
- CYP2J2 p.Cys448Tyr Uncertain significance Single submitter
- CYP2J2 p.Glu156Lys Uncertain significance Single submitter
- CYP2J2 p.Glu451Lys Uncertain significance Single submitter
- CYP2J2 p.Glu62Gly Uncertain significance Single submitter
- CYP2J2 p.Glu82Lys Uncertain significance Single submitter
- CYP2J2 p.Gly198Arg Uncertain significance Single submitter
- CYP2J2 p.Gly312Ala Uncertain significance Single submitter
- CYP2J2 p.Ile375Asn Uncertain significance Single submitter
- CYP2J2 p.Ile86Met Uncertain significance Single submitter
- CYP2J2 p.Leu101Arg Uncertain significance Single submitter
- CYP2J2 p.Leu308Pro Uncertain significance Single submitter
- CYP2J2 p.Lys122Thr Uncertain significance Single submitter
- CYP2J2 p.Ser304Arg Uncertain significance Single submitter
- CYP2J2 p.Thr219Ile Uncertain significance Single submitter
- CYP2J2 p.Thr313Ile Uncertain significance Single submitter
- CYP2J2 p.Tyr220Cys Uncertain significance Single submitter
- CYP2J2 p.Val502Met Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- CYP2J2 p.Ala163Thr Uncertain significance Single submitter
- CYP2J2 p.Ala454Ser Uncertain significance Single submitter
- CYP2J2 p.Arg117Gln Uncertain significance Single submitter
- CYP2J2 p.Arg158His Uncertain significance Single submitter
- CYP2J2 p.Arg321Gln Uncertain significance Single submitter
- CYP2J2 p.Arg39Cys Uncertain significance Single submitter
- CYP2J2 p.Arg472Ser Uncertain significance Single submitter
- CYP2J2 p.Arg495Cys Uncertain significance Single submitter
- CYP2J2 p.Arg495Ser Uncertain significance Single submitter
- CYP2J2 p.Asn110Ile Uncertain significance Single submitter
- CYP2J2 p.Asn250Lys Uncertain significance Single submitter
- CYP2J2 p.Asn42Thr Uncertain significance Single submitter
- CYP2J2 p.Asn77Ile Uncertain significance Single submitter
- CYP2J2 p.Asp179Glu Uncertain significance Single submitter
- CYP2J2 p.Asp419Tyr Uncertain significance Single submitter
- CYP2J2 p.Gln228Glu Uncertain significance Single submitter
- CYP2J2 p.Glu161Lys Uncertain significance Single submitter
- CYP2J2 p.Glu173Lys Uncertain significance Single submitter
- CYP2J2 p.Glu477Lys Uncertain significance Single submitter
- CYP2J2 p.His367Arg Uncertain significance Single submitter
- CYP2J2 p.Ile192Val Uncertain significance Single submitter
- CYP2J2 p.Ile262Thr Uncertain significance Single submitter
- CYP2J2 p.Ile278Thr Uncertain significance Single submitter
- CYP2J2 p.Leu142Val Uncertain significance Single submitter
- CYP2J2 p.Leu254Met Uncertain significance Single submitter
- CYP2J2 p.Leu256Phe Uncertain significance Single submitter
- CYP2J2 p.Lys264Thr Uncertain significance Single submitter
- CYP2J2 p.Lys41Glu Uncertain significance Single submitter
- CYP2J2 p.Met128Thr Uncertain significance Single submitter
- CYP2J2 p.Phe277Val Uncertain significance Single submitter
- CYP2J2 p.Phe483Ile Uncertain significance Single submitter
- CYP2J2 p.Phe57Ser Uncertain significance Single submitter
- CYP2J2 p.Pro45Leu Uncertain significance Single submitter
- CYP2J2 p.Ser295Gly Uncertain significance Single submitter
- CYP2J2 p.Thr114Asn Uncertain significance Single submitter
- CYP2J2 p.Thr406Met Uncertain significance Single submitter
- CYP2J2 p.Thr420Ile Uncertain significance Single submitter
- CYP2J2 p.Val365Ile Uncertain significance Single submitter
- CYP2J2 p.Val384Gly Uncertain significance Single submitter
All CYP2J2 variants
Likely benign 3
- p.Ala355Thr Single submitter
- p.Ala447Val Single submitter
- p.Pro112= Single submitter
Uncertain significance 63
- p.Ala133Thr Single submitter ⚠
- p.Ala14Pro Single submitter ⚠
- p.Ala163Thr Single submitter ⚠
- p.Ala454Ser Single submitter ⚠
- p.Ala4Glu Single submitter ⚠
- p.Ala9Ser Single submitter ⚠
- p.Arg117Gln Single submitter ⚠
- p.Arg158His Single submitter ⚠
- p.Arg321Gln Single submitter ⚠
- p.Arg39Cys Single submitter ⚠
- p.Arg472Ser Single submitter ⚠
- p.Arg495Cys Single submitter ⚠
- p.Arg495Ser Single submitter ⚠
- p.Asn110Ile Single submitter ⚠
- p.Asn250Lys Single submitter ⚠
- p.Asn42Thr Single submitter ⚠
- p.Asn476Lys Single submitter ⚠
- p.Asn77Ile Single submitter ⚠
- p.Asp179Glu Single submitter ⚠
- p.Asp279Glu Single submitter ⚠
- p.Asp419Tyr Single submitter ⚠
- p.Asp85Asn Single submitter ⚠
- p.Cys448Tyr Single submitter ⚠
- p.Gln228Glu Single submitter ⚠
- p.Glu156Lys Single submitter ⚠
- p.Glu161Lys Single submitter ⚠
- p.Glu173Lys Single submitter ⚠
- p.Glu451Lys Single submitter ⚠
- p.Glu477Lys Single submitter ⚠
- p.Glu62Gly Single submitter ⚠
- p.Glu82Lys Single submitter ⚠
- p.Gly198Arg Single submitter ⚠
- p.Gly312Ala Single submitter ⚠
- p.His367Arg Single submitter ⚠
- p.Ile192Val Single submitter ⚠
- p.Ile262Thr Single submitter ⚠
- p.Ile278Thr Single submitter ⚠
- p.Ile375Asn Single submitter ⚠
- p.Ile86Met Single submitter ⚠
- p.Leu101Arg Single submitter ⚠
- p.Leu142Val Single submitter ⚠
- p.Leu254Met Single submitter ⚠
- p.Leu256Phe Single submitter ⚠
- p.Leu308Pro Single submitter ⚠
- p.Lys122Thr Single submitter ⚠
- p.Lys264Thr Single submitter ⚠
- p.Lys41Glu Single submitter ⚠
- p.Met128Thr Single submitter ⚠
- p.Phe277Val Single submitter ⚠
- p.Phe483Ile Single submitter ⚠
- p.Phe57Ser Single submitter ⚠
- p.Pro45Leu Single submitter ⚠
- p.Ser295Gly Single submitter ⚠
- p.Ser304Arg Single submitter ⚠
- p.Thr114Asn Single submitter ⚠
- p.Thr219Ile Single submitter ⚠
- p.Thr313Ile Single submitter ⚠
- p.Thr406Met Single submitter ⚠
- p.Thr420Ile Single submitter ⚠
- p.Tyr220Cys Single submitter ⚠
- p.Val365Ile Single submitter ⚠
- p.Val384Gly Single submitter ⚠
- p.Val502Met Single submitter ⚠