CYP2W1 — 128 ClinVar variants
All ClinVar germline CYP2W1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 119 flagged for review →
3 Benign · 9 Likely benign · 116 Uncertain significance
Full CYP2W1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 119
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP2W1 p.Ala169Thr Uncertain significance Single submitter
- CYP2W1 p.Ala369Thr Uncertain significance Single submitter
- CYP2W1 p.Ala472Thr Uncertain significance Single submitter
- CYP2W1 p.Ala474Thr Uncertain significance Single submitter
- CYP2W1 p.Arg126Pro Uncertain significance Single submitter
- CYP2W1 p.Arg186Cys Uncertain significance Single submitter
- CYP2W1 p.Arg251Gln Uncertain significance Single submitter
- CYP2W1 p.Arg334Gln Uncertain significance Single submitter
- CYP2W1 p.Arg356Gln Uncertain significance Single submitter
- CYP2W1 p.Arg455Cys Uncertain significance Single submitter
- CYP2W1 p.Arg473Gln Uncertain significance Single submitter
- CYP2W1 p.Arg473Trp Uncertain significance Single submitter
- CYP2W1 p.Asp203Asn Uncertain significance Single submitter
- CYP2W1 p.Asp266Glu Uncertain significance Single submitter
- CYP2W1 p.Asp371Glu Uncertain significance Single submitter
- CYP2W1 p.Gln109Arg Uncertain significance Single submitter
- CYP2W1 p.Gly10Val Uncertain significance Single submitter
- CYP2W1 p.Gly185Cys Uncertain significance Single submitter
- CYP2W1 p.Gly200Ala Uncertain significance Single submitter
- CYP2W1 p.Gly272Arg Uncertain significance Single submitter
- CYP2W1 p.Gly42Arg Uncertain significance Single submitter
- CYP2W1 p.Gly64Arg Uncertain significance Single submitter
- CYP2W1 p.His315Tyr Uncertain significance Single submitter
- CYP2W1 p.His70Tyr Uncertain significance Single submitter
- CYP2W1 p.Ile114Ser Uncertain significance Single submitter
- CYP2W1 p.Ile114Val Uncertain significance Single submitter
- CYP2W1 p.Leu136Pro Uncertain significance Single submitter
- CYP2W1 p.Leu351Phe Uncertain significance Single submitter
- CYP2W1 p.Leu361Val Uncertain significance Single submitter
- CYP2W1 p.Leu446Pro Uncertain significance Single submitter
- CYP2W1 p.Met57Thr Uncertain significance Single submitter
- CYP2W1 p.Phe115Ile Uncertain significance Single submitter
- CYP2W1 p.Phe217Ser Uncertain significance Single submitter
- CYP2W1 p.Pro362Leu Uncertain significance Single submitter
- CYP2W1 p.Pro39Thr Uncertain significance Single submitter
- CYP2W1 p.Pro479Leu Uncertain significance Single submitter
- CYP2W1 p.Ser391Leu Uncertain significance Single submitter
- CYP2W1 p.Trp122Leu Uncertain significance Single submitter
- CYP2W1 p.Trp173Ser Uncertain significance Single submitter
- CYP2W1 p.Val138Met Uncertain significance Single submitter
- CYP2W1 p.Val240Ile Uncertain significance Single submitter
Predictors split 78
The independent predictors disagree with each other — read with care.
- CYP2W1 p.Ala120Val Uncertain significance Single submitter
- CYP2W1 p.Ala124Ser Uncertain significance Single submitter
- CYP2W1 p.Ala181Val Uncertain significance Single submitter
- CYP2W1 p.Ala20Thr Uncertain significance Single submitter
- CYP2W1 p.Ala250Val Uncertain significance Single submitter
- CYP2W1 p.Ala284Val Uncertain significance Single submitter
- CYP2W1 p.Ala413Thr Uncertain significance Single submitter
- CYP2W1 p.Ala428Thr Uncertain significance Single submitter
- CYP2W1 p.Arg121His Uncertain significance Single submitter
- CYP2W1 p.Arg126His Uncertain significance Single submitter
- CYP2W1 p.Arg140Trp Uncertain significance Single submitter
- CYP2W1 p.Arg164Trp Uncertain significance Single submitter
- CYP2W1 p.Arg231Trp Uncertain significance Single submitter
- CYP2W1 p.Arg235Cys Uncertain significance Single submitter
- CYP2W1 p.Arg241Cys Uncertain significance Single submitter
- CYP2W1 p.Arg241His Uncertain significance Single submitter
- CYP2W1 p.Arg251Trp Uncertain significance Single submitter
- CYP2W1 p.Arg30Gln Uncertain significance Single submitter
- CYP2W1 p.Arg321Gly Uncertain significance Single submitter
- CYP2W1 p.Arg328Cys Uncertain significance Single submitter
- CYP2W1 p.Arg328His Benign Single submitter
- CYP2W1 p.Arg328Leu Uncertain significance Single submitter
- CYP2W1 p.Arg337Trp Uncertain significance Single submitter
- CYP2W1 p.Arg366Cys Uncertain significance Single submitter
- CYP2W1 p.Arg36His Uncertain significance Single submitter
- CYP2W1 p.Arg420Pro Uncertain significance Single submitter
- CYP2W1 p.Arg430Cys Uncertain significance Single submitter
- CYP2W1 p.Arg437His Uncertain significance Single submitter
- CYP2W1 p.Arg62Cys Uncertain significance Single submitter
- CYP2W1 p.Arg73Cys Likely benign Single submitter
- CYP2W1 p.Asn406Ser Uncertain significance Single submitter
- CYP2W1 p.Asp259Asn Uncertain significance Single submitter
- CYP2W1 p.Asp275Tyr Uncertain significance Single submitter
- CYP2W1 p.Asp276Val Uncertain significance Single submitter
- CYP2W1 p.Asp98Asn Uncertain significance Single submitter
- CYP2W1 p.Cys485Arg Uncertain significance Single submitter
- CYP2W1 p.Gln127Leu Uncertain significance Single submitter
- CYP2W1 p.Glu238Lys Uncertain significance Single submitter
- CYP2W1 p.Glu249Lys Uncertain significance Single submitter
- CYP2W1 p.Gly172Asp Uncertain significance Single submitter
- CYP2W1 p.Gly279Val Uncertain significance Single submitter
- CYP2W1 p.Gly461Asp Uncertain significance Single submitter
- CYP2W1 p.Gly93Arg Uncertain significance Single submitter
- CYP2W1 p.His134Tyr Uncertain significance Single submitter
- CYP2W1 p.Ile243Thr Uncertain significance Single submitter
- CYP2W1 p.Ile269Met Uncertain significance Single submitter
- CYP2W1 p.Leu280Met Uncertain significance Single submitter
- CYP2W1 p.Leu393Phe Uncertain significance Single submitter
- CYP2W1 p.Lys75Glu Uncertain significance Single submitter
- CYP2W1 p.Met206Ile Uncertain significance Single submitter
- CYP2W1 p.Phe281Leu Uncertain significance Single submitter
- CYP2W1 p.Pro175Leu Uncertain significance Single submitter
- CYP2W1 p.Pro221Ala Uncertain significance Single submitter
- CYP2W1 p.Pro232Ala Uncertain significance Single submitter
- CYP2W1 p.Pro253Ser Uncertain significance Single submitter
- CYP2W1 p.Pro316Leu Uncertain significance Single submitter
- CYP2W1 p.Pro362Ala Uncertain significance Single submitter
- CYP2W1 p.Pro387Thr Uncertain significance Single submitter
- CYP2W1 p.Pro402Ala Uncertain significance Single submitter
- CYP2W1 p.Pro464Ala Uncertain significance Single submitter
- CYP2W1 p.Ser26Phe Uncertain significance Single submitter
- CYP2W1 p.Ser302Leu Uncertain significance Single submitter
- CYP2W1 p.Ser427Cys Uncertain significance Single submitter
- CYP2W1 p.Ser50Leu Uncertain significance Single submitter
- CYP2W1 p.Thr179Asn Uncertain significance Single submitter
- CYP2W1 p.Thr359Arg Uncertain significance Single submitter
- CYP2W1 p.Thr359Met Uncertain significance Single submitter
- CYP2W1 p.Tyr63Cys Uncertain significance Single submitter
- CYP2W1 p.Val143Glu Uncertain significance Single submitter
- CYP2W1 p.Val255Met Likely benign Single submitter
- CYP2W1 p.Val261Met Uncertain significance Single submitter
- CYP2W1 p.Val318Gly Uncertain significance Single submitter
- CYP2W1 p.Val322Met Uncertain significance Single submitter
- CYP2W1 p.Val329Met Uncertain significance Single submitter
- CYP2W1 p.Val350Met Uncertain significance Single submitter
- CYP2W1 p.Val364Ala Uncertain significance Single submitter
- CYP2W1 p.Val364Met Uncertain significance Single submitter
- CYP2W1 p.Val69Met Uncertain significance Single submitter
All CYP2W1 variants
Benign 3
- p.Arg328His Single submitter ⚠
- p.Ile102= Single submitter
- p.Pro257= Single submitter
Likely benign 9
- p.Ala284Asp Single submitter
- p.Ala90Val Single submitter
- p.Arg337Gln Single submitter
- p.Arg73Cys Single submitter ⚠
- p.Leu183Val Single submitter
- p.Leu223= Single submitter
- p.Pro142= Single submitter
- p.Val219Ile Single submitter
- p.Val255Met Single submitter ⚠
Uncertain significance 116
- p.Ala120Val Single submitter ⚠
- p.Ala124Ser Single submitter ⚠
- p.Ala169Thr Single submitter ⚠
- p.Ala181Val Single submitter ⚠
- p.Ala20Thr Single submitter ⚠
- p.Ala250Val Single submitter ⚠
- p.Ala284Val Single submitter ⚠
- p.Ala369Thr Single submitter ⚠
- p.Ala413Thr Single submitter ⚠
- p.Ala428Thr Single submitter ⚠
- p.Ala472Thr Single submitter ⚠
- p.Ala474Thr Single submitter ⚠
- p.Arg121His Single submitter ⚠
- p.Arg126His Single submitter ⚠
- p.Arg126Pro Single submitter ⚠
- p.Arg140Trp Single submitter ⚠
- p.Arg164Trp Single submitter ⚠
- p.Arg186Cys Single submitter ⚠
- p.Arg231Trp Single submitter ⚠
- p.Arg235Cys Single submitter ⚠
- p.Arg241Cys Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg251Gln Single submitter ⚠
- p.Arg251Trp Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg321Gly Single submitter ⚠
- p.Arg328Cys Single submitter ⚠
- p.Arg328Leu Single submitter ⚠
- p.Arg334Gln Single submitter ⚠
- p.Arg337Trp Single submitter ⚠
- p.Arg356Gln Single submitter ⚠
- p.Arg366Cys Single submitter ⚠
- p.Arg36His Single submitter ⚠
- p.Arg420Pro Single submitter ⚠
- p.Arg430Cys Single submitter ⚠
- p.Arg437His Single submitter ⚠
- p.Arg455Cys Single submitter ⚠
- p.Arg473Gln Single submitter ⚠
- p.Arg473Trp Single submitter ⚠
- p.Arg62Cys Single submitter ⚠
- p.Asn406Ser Single submitter ⚠
- p.Asp203Asn Single submitter ⚠
- p.Asp259Asn Single submitter ⚠
- p.Asp266Glu Single submitter ⚠
- p.Asp275Tyr Single submitter ⚠
- p.Asp276Val Single submitter ⚠
- p.Asp371Glu Single submitter ⚠
- p.Asp98Asn Single submitter ⚠
- p.Cys485Arg Single submitter ⚠
- p.Gln109Arg Single submitter ⚠
- p.Gln127Leu Single submitter ⚠
- p.Glu238Lys Single submitter ⚠
- p.Glu249Lys Single submitter ⚠
- p.Gly10Val Single submitter ⚠
- p.Gly172Asp Single submitter ⚠
- p.Gly185Cys Single submitter ⚠
- p.Gly200Ala Single submitter ⚠
- p.Gly272Arg Single submitter ⚠
- p.Gly279Val Single submitter ⚠
- p.Gly42Arg Single submitter ⚠
- p.Gly461Asp Single submitter ⚠
- p.Gly64Arg Single submitter ⚠
- p.Gly93Arg Single submitter ⚠
- p.His134Tyr Single submitter ⚠
- p.His315Tyr Single submitter ⚠
- p.His70Tyr Single submitter ⚠
- p.Ile114Ser Single submitter ⚠
- p.Ile114Val Single submitter ⚠
- p.Ile243Thr Single submitter ⚠
- p.Ile269Met Single submitter ⚠
- p.Leu136Pro Single submitter ⚠
- p.Leu280Met Single submitter ⚠
- p.Leu351Phe Single submitter ⚠
- p.Leu361Val Single submitter ⚠
- p.Leu393Phe Single submitter ⚠
- p.Leu446Pro Single submitter ⚠
- p.Lys75Glu Single submitter ⚠
- p.Met206Ile Single submitter ⚠
- p.Met57Thr Single submitter ⚠
- p.Phe115Ile Single submitter ⚠
- p.Phe217Ser Single submitter ⚠
- p.Phe281Leu Single submitter ⚠
- p.Pro175Leu Single submitter ⚠
- p.Pro221Ala Single submitter ⚠
- p.Pro232Ala Single submitter ⚠
- p.Pro253Ser Single submitter ⚠
- p.Pro316Leu Single submitter ⚠
- p.Pro362Ala Single submitter ⚠
- p.Pro362Leu Single submitter ⚠
- p.Pro387Thr Single submitter ⚠
- p.Pro39Thr Single submitter ⚠
- p.Pro402Ala Single submitter ⚠
- p.Pro464Ala Single submitter ⚠
- p.Pro479Leu Single submitter ⚠
- p.Ser26Phe Single submitter ⚠
- p.Ser302Leu Single submitter ⚠
- p.Ser391Leu Single submitter ⚠
- p.Ser427Cys Single submitter ⚠
- p.Ser50Leu Single submitter ⚠
- p.Thr179Asn Single submitter ⚠
- p.Thr359Arg Single submitter ⚠
- p.Thr359Met Single submitter ⚠
- p.Trp122Leu Single submitter ⚠
- p.Trp173Ser Single submitter ⚠
- p.Tyr63Cys Single submitter ⚠
- p.Val138Met Single submitter ⚠
- p.Val143Glu Single submitter ⚠
- p.Val240Ile Single submitter ⚠
- p.Val261Met Single submitter ⚠
- p.Val318Gly Single submitter ⚠
- p.Val322Met Single submitter ⚠
- p.Val329Met Single submitter ⚠
- p.Val350Met Single submitter ⚠
- p.Val364Ala Single submitter ⚠
- p.Val364Met Single submitter ⚠
- p.Val69Met Single submitter ⚠