CYP3A7 — 71 ClinVar variants
All ClinVar germline CYP3A7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Benign · 8 Likely benign · 62 Uncertain significance
Full CYP3A7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP3A7 p.Ala455Asp Uncertain significance Single submitter
- CYP3A7 p.Arg478Cys Uncertain significance Single submitter
- CYP3A7 p.Arg478His Uncertain significance Single submitter
- CYP3A7 p.Asn214Lys Uncertain significance Single submitter
- CYP3A7 p.Asn426Lys Uncertain significance Single submitter
- CYP3A7 p.Asp123Asn Uncertain significance Single submitter
- CYP3A7 p.Cys442Phe Uncertain significance Single submitter
- CYP3A7 p.Glu144Lys Uncertain significance Single submitter
- CYP3A7 p.Glu165Gln Uncertain significance Single submitter
- CYP3A7 p.Glu308Ala Uncertain significance Single submitter
- CYP3A7 p.Glu498Lys Uncertain significance Single submitter
- CYP3A7 p.Gly438Glu Uncertain significance Single submitter
- CYP3A7 p.His287Tyr Uncertain significance Single submitter
- CYP3A7 p.Ile129Lys Uncertain significance Single submitter
- CYP3A7 p.Ile246Leu Uncertain significance Single submitter
- CYP3A7 p.Ile246Val Uncertain significance Single submitter
- CYP3A7 p.Ile443Thr Uncertain significance Single submitter
- CYP3A7 p.Leu216Ser Uncertain significance Single submitter
- CYP3A7 p.Leu290Arg Uncertain significance Single submitter
- CYP3A7 p.Leu32Val Uncertain significance Single submitter
- CYP3A7 p.Leu401Pro Uncertain significance Single submitter
- CYP3A7 p.Leu51Phe Uncertain significance Single submitter
- CYP3A7 p.Met358Ile Uncertain significance Single submitter
- CYP3A7 p.Met371Ile Uncertain significance Single submitter
- CYP3A7 p.Met395Thr Uncertain significance Single submitter
- CYP3A7 p.Phe203Leu Uncertain significance Single submitter
- CYP3A7 p.Pro344Ala Uncertain significance Single submitter
- CYP3A7 p.Pro368Ser Uncertain significance Single submitter
- CYP3A7 p.Ser247Arg Uncertain significance Single submitter
- CYP3A7 p.Ser252Thr Uncertain significance Single submitter
- CYP3A7 p.Ser315Phe Uncertain significance Single submitter
- CYP3A7 p.Ser420Gly Uncertain significance Single submitter
- CYP3A7 p.Thr286Asn Uncertain significance Single submitter
- CYP3A7 p.Thr471Ala Uncertain significance Single submitter
- CYP3A7 p.Trp12Leu Uncertain significance Single submitter
- CYP3A7 p.Val101Ala Uncertain significance Single submitter
- CYP3A7 p.Val220Ile Uncertain significance Single submitter
- CYP3A7 p.Val392Met Uncertain significance Single submitter
- CYP3A7 p.Val393Ala Uncertain significance Single submitter
- CYP3A7 p.Val400Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CYP3A7 p.Arg162Trp Uncertain significance Single submitter
- CYP3A7 p.Asn423Ile Uncertain significance Single submitter
- CYP3A7 p.Asn441Lys Uncertain significance Single submitter
- CYP3A7 p.Asp326His Uncertain significance Single submitter
- CYP3A7 p.Gly112Arg Uncertain significance Single submitter
- CYP3A7 p.Gly385Glu Uncertain significance Single submitter
- CYP3A7 p.Met358Val Uncertain significance Single submitter
- CYP3A7 p.Met371Lys Uncertain significance Single submitter
- CYP3A7 p.Phe367Leu Uncertain significance Single submitter
- CYP3A7 p.Pro231Leu Uncertain significance Single submitter
- CYP3A7 p.Ser180Cys Uncertain significance Single submitter
- CYP3A7 p.Ser311Gly Uncertain significance Single submitter
- CYP3A7 p.Thr485Arg Uncertain significance Single submitter
- CYP3A7 p.Val376Phe Uncertain significance Single submitter
All CYP3A7 variants
Benign 1
- p.Val71Ala Multiple submitters
Likely benign 8
- p.Ala50Val Single submitter
- p.Asn426Ser Single submitter
- p.Ile318Met Single submitter
- p.Leu142= Single submitter
- p.Leu233Phe Single submitter
- p.Leu353Met Single submitter
- p.Ser192Asn Single submitter
- p.Val400Ala Single submitter
Uncertain significance 62
- c.866-1G>T Single submitter
- p.Ala455Asp Single submitter ⚠
- p.Arg162Trp Single submitter ⚠
- p.Arg260His Single submitter
- p.Arg478Cys Single submitter ⚠
- p.Arg478His Single submitter ⚠
- p.Asn214Lys Single submitter ⚠
- p.Asn423Ile Single submitter ⚠
- p.Asn426Lys Single submitter ⚠
- p.Asn441Lys Single submitter ⚠
- p.Asp123Asn Single submitter ⚠
- p.Asp326His Single submitter ⚠
- p.Cys442Phe Single submitter ⚠
- p.Cys64Tyr Single submitter
- p.Glu144Lys Single submitter ⚠
- p.Glu165Gln Single submitter ⚠
- p.Glu308Ala Single submitter ⚠
- p.Glu498Lys Single submitter ⚠
- p.Gly112Arg Single submitter ⚠
- p.Gly385Glu Single submitter ⚠
- p.Gly438Glu Single submitter ⚠
- p.His287Tyr Single submitter ⚠
- p.Ile129Lys Single submitter ⚠
- p.Ile149Thr Single submitter
- p.Ile246Leu Single submitter ⚠
- p.Ile246Val Single submitter ⚠
- p.Ile443Thr Single submitter ⚠
- p.Leu216Ser Single submitter ⚠
- p.Leu290Arg Single submitter ⚠
- p.Leu32Val Single submitter ⚠
- p.Leu401Pro Single submitter ⚠
- p.Leu51Phe Single submitter ⚠
- p.Met358Ile Single submitter ⚠
- p.Met358Val Single submitter ⚠
- p.Met371Ile Single submitter ⚠
- p.Met371Lys Single submitter ⚠
- p.Met395Thr Single submitter ⚠
- p.Phe203Leu Single submitter ⚠
- p.Phe367Leu Single submitter ⚠
- p.Pro218Gln Single submitter
- p.Pro231Leu Single submitter ⚠
- p.Pro344Ala Single submitter ⚠
- p.Pro368Ser Single submitter ⚠
- p.Ser180Cys Single submitter ⚠
- p.Ser247Arg Single submitter ⚠
- p.Ser252Thr Single submitter ⚠
- p.Ser311Gly Single submitter ⚠
- p.Ser315Phe Single submitter ⚠
- p.Ser420Gly Single submitter ⚠
- p.Thr286Asn Single submitter ⚠
- p.Thr310Met Single submitter
- p.Thr471Ala Single submitter ⚠
- p.Thr485Arg Single submitter ⚠
- p.Trp12Leu Single submitter ⚠
- p.Tyr68His Single submitter
- p.Val101Ala Single submitter ⚠
- p.Val191Ala Single submitter
- p.Val220Ile Single submitter ⚠
- p.Val376Phe Single submitter ⚠
- p.Val392Met Single submitter ⚠
- p.Val393Ala Single submitter ⚠
- p.Val400Ile Single submitter ⚠