CYP4A11 — 93 ClinVar variants

All ClinVar germline CYP4A11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →

2 Benign · 5 Likely benign · 86 Uncertain significance

Full CYP4A11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 77

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 58

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 19

The independent predictors disagree with each other — read with care.

All CYP4A11 variants

Benign 2

p.Ile487= Multiple submitters
c.337+9G>A Single submitter

Likely benign 5

p.Arg74Gln Single submitter
p.Gln68Lys Single submitter
p.His204Tyr Single submitter
p.His40= Single submitter
p.Val189Ile Single submitter

Uncertain significance 86

p.Ala163Val Single submitter ⚠
p.Ala220Gly Single submitter ⚠
p.Ala22Asp Single submitter ⚠
p.Ala272Pro Single submitter ⚠
p.Ala298Thr Single submitter ⚠
p.Ala313Thr Single submitter
p.Ala379Thr Single submitter ⚠
p.Ala437Ser Single submitter ⚠
p.Ala472Thr Single submitter
p.Ala492Ser Single submitter ⚠
p.Arg144Gln Single submitter ⚠
p.Arg144Trp Single submitter
p.Arg250Cys Single submitter ⚠
p.Arg250Leu Single submitter ⚠
p.Arg312His Single submitter ⚠
p.Arg403Cys Single submitter ⚠
p.Arg403His Single submitter ⚠
p.Arg41Lys Single submitter ⚠
p.Arg505Gly Single submitter ⚠
p.Arg74Trp Single submitter ⚠
p.Arg96Cys Single submitter ⚠
p.Asn456Lys Single submitter ⚠
p.Asn465His Single submitter ⚠
p.Asp164Gly Single submitter ⚠
p.Asp211Tyr Single submitter ⚠
p.Asp264Glu Single submitter ⚠
p.Asp290His Single submitter ⚠
p.Asp308Glu Single submitter ⚠
p.Asp324Asn Single submitter ⚠
p.Cys200Tyr Single submitter ⚠
p.Cys256Gly Single submitter ⚠
p.Gln238Glu Single submitter ⚠
p.Gln268Arg Single submitter ⚠
p.Gln42Arg Single submitter ⚠
p.Glu314Asp Single submitter ⚠
p.Glu466Gln Single submitter
p.Gly206Asp Single submitter ⚠
p.Gly206Ser Single submitter ⚠
p.Gly329Val Single submitter ⚠
p.Gly356Asp Single submitter ⚠
p.Gly388Val Single submitter ⚠
p.Gly439Ala Single submitter ⚠
p.Gly453Val Single submitter ⚠
p.His260Arg Single submitter ⚠
p.His420Arg Single submitter ⚠
p.Ile26Thr Single submitter ⚠
p.Ile283Met Single submitter ⚠
p.Ile330Met Single submitter ⚠
p.Ile361Leu Single submitter ⚠
p.Ile458Thr Single submitter ⚠
p.Ile63Leu Single submitter ⚠
p.Leu170Pro Single submitter ⚠
p.Leu183Pro Single submitter ⚠
p.Leu30Gln Single submitter
p.Leu334His Single submitter ⚠
p.Leu37Ile Single submitter ⚠
p.Leu418Ile Single submitter ⚠
p.Leu90Ile Single submitter ⚠
p.Lys271Asn Single submitter ⚠
p.Lys282Thr Single submitter ⚠
p.Met198Arg Single submitter ⚠
p.Met410Ile Single submitter ⚠
p.Met410Val Single submitter ⚠
p.Phe60Cys Single submitter ⚠
p.Pro114Leu Single submitter ⚠
p.Pro157Leu Single submitter
p.Pro341Thr Single submitter ⚠
p.Pro385Leu Single submitter ⚠
p.Pro422Thr Single submitter ⚠
p.Pro484Ala Single submitter ⚠
p.Pro490Ser Single submitter ⚠
p.Pro512Arg Single submitter ⚠
p.Pro83Ser Single submitter ⚠
p.Pro87Ala Single submitter ⚠
p.Pro87Arg Single submitter
p.Ser207Arg Single submitter ⚠
p.Ser244Asn Single submitter ⚠
p.Thr241Ser Single submitter ⚠
p.Thr317Met Single submitter ⚠
p.Thr326Ile Single submitter ⚠
p.Thr362Ile Single submitter
p.Thr471Met Single submitter ⚠
p.Trp425Ser Single submitter ⚠
p.Tyr38His Single submitter ⚠
p.Val168Met Single submitter ⚠
p.Val397Phe Single submitter