CYP4F11 — 111 ClinVar variants
All ClinVar germline CYP4F11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 96 flagged for review →
8 Likely benign · 103 Uncertain significance
Full CYP4F11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 96
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP4F11 p.Ala116Val Uncertain significance Single submitter
- CYP4F11 p.Ala15Val Uncertain significance Single submitter
- CYP4F11 p.Ala224Thr Uncertain significance Single submitter
- CYP4F11 p.Ala376Val Uncertain significance Single submitter
- CYP4F11 p.Ala457Pro Uncertain significance Single submitter
- CYP4F11 p.Arg108Gln Uncertain significance Single submitter
- CYP4F11 p.Arg188Thr Uncertain significance Single submitter
- CYP4F11 p.Arg412Cys Uncertain significance Single submitter
- CYP4F11 p.Arg46His Uncertain significance Single submitter
- CYP4F11 p.Arg499His Uncertain significance Single submitter
- CYP4F11 p.Asp142Gly Uncertain significance Single submitter
- CYP4F11 p.Asp284Glu Uncertain significance Single submitter
- CYP4F11 p.Asp285Asn Uncertain significance Single submitter
- CYP4F11 p.Asp297Glu Uncertain significance Single submitter
- CYP4F11 p.Asp309Glu Uncertain significance Single submitter
- CYP4F11 p.Gln237Lys Uncertain significance Single submitter
- CYP4F11 p.Gln272Arg Uncertain significance Single submitter
- CYP4F11 p.Gln281Arg Uncertain significance Single submitter
- CYP4F11 p.Gln3Glu Uncertain significance Single submitter
- CYP4F11 p.Gln49His Uncertain significance Single submitter
- CYP4F11 p.Glu71Lys Uncertain significance Single submitter
- CYP4F11 p.Gly10Arg Uncertain significance Single submitter
- CYP4F11 p.Gly10Asp Uncertain significance Single submitter
- CYP4F11 p.Gly282Ser Uncertain significance Single submitter
- CYP4F11 p.Gly336Arg Uncertain significance Single submitter
- CYP4F11 p.His147Arg Uncertain significance Single submitter
- CYP4F11 p.His194Tyr Uncertain significance Single submitter
- CYP4F11 p.His261Gln Uncertain significance Single submitter
- CYP4F11 p.Ile106Val Uncertain significance Single submitter
- CYP4F11 p.Ile491Phe Uncertain significance Single submitter
- CYP4F11 p.Leu24Met Uncertain significance Single submitter
- CYP4F11 p.Leu35Val Uncertain significance Single submitter
- CYP4F11 p.Leu504Pro Uncertain significance Single submitter
- CYP4F11 p.Leu9Val Uncertain significance Single submitter
- CYP4F11 p.Met150Ile Uncertain significance Single submitter
- CYP4F11 p.Met383Ile Uncertain significance Single submitter
- CYP4F11 p.Phe210Tyr Uncertain significance Single submitter
- CYP4F11 p.Phe458Val Uncertain significance Single submitter
- CYP4F11 p.Pro18Arg Uncertain significance Single submitter
- CYP4F11 p.Pro18Leu Uncertain significance Single submitter
- CYP4F11 p.Pro18Ser Uncertain significance Single submitter
- CYP4F11 p.Pro279Leu Uncertain significance Single submitter
- CYP4F11 p.Pro279Ser Uncertain significance Single submitter
- CYP4F11 p.Pro2Arg Uncertain significance Single submitter
- CYP4F11 p.Pro502Arg Uncertain significance Single submitter
- CYP4F11 p.Pro502Ser Uncertain significance Single submitter
- CYP4F11 p.Pro55Ala Uncertain significance Single submitter
- CYP4F11 p.Pro69Ser Uncertain significance Single submitter
- CYP4F11 p.Ser170Arg Uncertain significance Single submitter
- CYP4F11 p.Ser209Arg Uncertain significance Single submitter
- CYP4F11 p.Ser219Asn Uncertain significance Single submitter
- CYP4F11 p.Ser462Leu Uncertain significance Single submitter
- CYP4F11 p.Ser5Gly Uncertain significance Single submitter
- CYP4F11 p.Ser7Thr Uncertain significance Single submitter
- CYP4F11 p.Thr111Asn Uncertain significance Single submitter
- CYP4F11 p.Thr243Lys Uncertain significance Single submitter
- CYP4F11 p.Thr332Ser Uncertain significance Single submitter
- CYP4F11 p.Thr40Ile Uncertain significance Single submitter
- CYP4F11 p.Thr496Ile Uncertain significance Single submitter
- CYP4F11 p.Trp339Cys Uncertain significance Single submitter
- CYP4F11 p.Tyr42His Uncertain significance Single submitter
- CYP4F11 p.Tyr440Cys Uncertain significance Single submitter
- CYP4F11 p.Val14Leu Uncertain significance Single submitter
- CYP4F11 p.Val14Met Uncertain significance Single submitter
- CYP4F11 p.Val270Ile Uncertain significance Single submitter
- CYP4F11 p.Val34Ile Uncertain significance Single submitter
- CYP4F11 p.Val395Ile Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- CYP4F11 p.Arg108Trp Uncertain significance Single submitter
- CYP4F11 p.Arg255Cys Uncertain significance Single submitter
- CYP4F11 p.Arg255His Uncertain significance Single submitter
- CYP4F11 p.Arg257Cys Uncertain significance Single submitter
- CYP4F11 p.Arg274Gln Uncertain significance Single submitter
- CYP4F11 p.Arg275Cys Uncertain significance Single submitter
- CYP4F11 p.Arg355Gln Uncertain significance Single submitter
- CYP4F11 p.Arg365Cys Uncertain significance Single submitter
- CYP4F11 p.Arg365His Uncertain significance Single submitter
- CYP4F11 p.Arg365Ser Uncertain significance Single submitter
- CYP4F11 p.Arg515Trp Uncertain significance Single submitter
- CYP4F11 p.Asn449Asp Uncertain significance Single submitter
- CYP4F11 p.Asp317Asn Uncertain significance Single submitter
- CYP4F11 p.Gly87Ser Uncertain significance Single submitter
- CYP4F11 p.His488Leu Uncertain significance Single submitter
- CYP4F11 p.Ile459Thr Uncertain significance Single submitter
- CYP4F11 p.Leu30His Uncertain significance Single submitter
- CYP4F11 p.Leu31Pro Uncertain significance Single submitter
- CYP4F11 p.Met383Arg Uncertain significance Single submitter
- CYP4F11 p.Phe192Ser Uncertain significance Single submitter
- CYP4F11 p.Pro104Ala Uncertain significance Single submitter
- CYP4F11 p.Pro396Ser Uncertain significance Single submitter
- CYP4F11 p.Pro431Ser Uncertain significance Single submitter
- CYP4F11 p.Pro435Leu Uncertain significance Single submitter
- CYP4F11 p.Pro493Leu Uncertain significance Single submitter
- CYP4F11 p.Thr70Met Uncertain significance Single submitter
- CYP4F11 p.Tyr125Cys Uncertain significance Single submitter
- CYP4F11 p.Tyr247Cys Uncertain significance Single submitter
- CYP4F11 p.Val439Phe Uncertain significance Single submitter
All CYP4F11 variants
Likely benign 8
- p.Ala472Val Single submitter
- p.Arg499Cys Single submitter
- p.Ile491Val Single submitter
- p.Lys363Arg Single submitter
- p.Pro2Leu Single submitter
- p.Val25Ala Single submitter
- p.Val413Ile Single submitter
- p.Val439= Single submitter
Uncertain significance 103
- p.Ala116Val Single submitter ⚠
- p.Ala15Val Single submitter ⚠
- p.Ala224Thr Single submitter ⚠
- p.Ala376Val Single submitter ⚠
- p.Ala457Pro Single submitter ⚠
- p.Arg108Gln Single submitter ⚠
- p.Arg108Trp Single submitter ⚠
- p.Arg188Thr Single submitter ⚠
- p.Arg255Cys Single submitter ⚠
- p.Arg255His Single submitter ⚠
- p.Arg257Cys Single submitter ⚠
- p.Arg274Gln Single submitter ⚠
- p.Arg275Cys Single submitter ⚠
- p.Arg355Gln Single submitter ⚠
- p.Arg365Cys Single submitter ⚠
- p.Arg365His Single submitter ⚠
- p.Arg365Ser Single submitter ⚠
- p.Arg412Cys Single submitter ⚠
- p.Arg46His Single submitter ⚠
- p.Arg499His Single submitter ⚠
- p.Arg515Trp Single submitter ⚠
- p.Asn449Asp Single submitter ⚠
- p.Asn58Lys Single submitter
- p.Asp142Gly Single submitter ⚠
- p.Asp284Glu Single submitter ⚠
- p.Asp285Asn Single submitter ⚠
- p.Asp297Glu Single submitter ⚠
- p.Asp309Glu Single submitter ⚠
- p.Asp317Asn Single submitter ⚠
- p.Gln237Lys Single submitter ⚠
- p.Gln272Arg Single submitter ⚠
- p.Gln281Arg Single submitter ⚠
- p.Gln3Glu Single submitter ⚠
- p.Gln49His Single submitter ⚠
- p.Glu71Lys Single submitter ⚠
- p.Gly10Arg Single submitter ⚠
- p.Gly10Asp Single submitter ⚠
- p.Gly26Glu Single submitter
- p.Gly282Ser Single submitter ⚠
- p.Gly336Arg Single submitter ⚠
- p.Gly87Ser Single submitter ⚠
- p.His147Arg Single submitter ⚠
- p.His194Tyr Single submitter ⚠
- p.His261Gln Single submitter ⚠
- p.His488Leu Single submitter ⚠
- p.Ile106Val Single submitter ⚠
- p.Ile459Thr Single submitter ⚠
- p.Ile491Phe Single submitter ⚠
- p.Leu200Phe Single submitter
- p.Leu24Met Single submitter ⚠
- p.Leu30His Single submitter ⚠
- p.Leu31Pro Single submitter ⚠
- p.Leu35Val Single submitter ⚠
- p.Leu492Pro Single submitter
- p.Leu504Pro Single submitter ⚠
- p.Leu9Val Single submitter ⚠
- p.Met150Ile Single submitter ⚠
- p.Met383Arg Single submitter ⚠
- p.Met383Ile Single submitter ⚠
- p.Phe192Ser Single submitter ⚠
- p.Phe210Tyr Single submitter ⚠
- p.Phe458Val Single submitter ⚠
- p.Pro104Ala Single submitter ⚠
- p.Pro18Arg Single submitter ⚠
- p.Pro18Leu Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro279Leu Single submitter ⚠
- p.Pro279Ser Single submitter ⚠
- p.Pro2Arg Single submitter ⚠
- p.Pro394Leu Single submitter
- p.Pro396Ser Single submitter ⚠
- p.Pro431Ser Single submitter ⚠
- p.Pro435Leu Single submitter ⚠
- p.Pro493Leu Single submitter ⚠
- p.Pro502Arg Single submitter ⚠
- p.Pro502Ser Single submitter ⚠
- p.Pro54Arg Single submitter
- p.Pro55Ala Single submitter ⚠
- p.Pro69Ser Single submitter ⚠
- p.Ser170Arg Single submitter ⚠
- p.Ser209Arg Single submitter ⚠
- p.Ser219Asn Single submitter ⚠
- p.Ser462Leu Single submitter ⚠
- p.Ser5Gly Single submitter ⚠
- p.Ser7Thr Single submitter ⚠
- p.Thr111Asn Single submitter ⚠
- p.Thr243Lys Single submitter ⚠
- p.Thr332Ser Single submitter ⚠
- p.Thr40Ile Single submitter ⚠
- p.Thr485Ile Single submitter
- p.Thr496Ile Single submitter ⚠
- p.Thr70Met Single submitter ⚠
- p.Trp339Cys Single submitter ⚠
- p.Tyr125Cys Single submitter ⚠
- p.Tyr247Cys Single submitter ⚠
- p.Tyr42His Single submitter ⚠
- p.Tyr440Cys Single submitter ⚠
- p.Val14Leu Single submitter ⚠
- p.Val14Met Single submitter ⚠
- p.Val270Ile Single submitter ⚠
- p.Val34Ile Single submitter ⚠
- p.Val395Ile Single submitter ⚠
- p.Val439Phe Single submitter ⚠