CYP4F12 — 92 ClinVar variants
All ClinVar germline CYP4F12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
7 Likely benign · 85 Uncertain significance
Full CYP4F12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP4F12 p.Ala472Pro Uncertain significance Single submitter
- CYP4F12 p.Ala472Val Uncertain significance Single submitter
- CYP4F12 p.Ala474Thr Uncertain significance Single submitter
- CYP4F12 p.Arg108Gln Uncertain significance Single submitter
- CYP4F12 p.Arg126Lys Uncertain significance Single submitter
- CYP4F12 p.Arg188His Uncertain significance Single submitter
- CYP4F12 p.Arg261His Uncertain significance Single submitter
- CYP4F12 p.Arg353His Uncertain significance Single submitter
- CYP4F12 p.Arg365Pro Uncertain significance Single submitter
- CYP4F12 p.Arg390Thr Uncertain significance Single submitter
- CYP4F12 p.Arg412Gln Uncertain significance Single submitter
- CYP4F12 p.Arg444Pro Uncertain significance Single submitter
- CYP4F12 p.Arg499His Uncertain significance Single submitter
- CYP4F12 p.Arg507Ser Uncertain significance Single submitter
- CYP4F12 p.Arg515Pro Uncertain significance Single submitter
- CYP4F12 p.Asn449Ser Uncertain significance Single submitter
- CYP4F12 p.Asp201Gly Uncertain significance Single submitter
- CYP4F12 p.Asp331Asn Uncertain significance Single submitter
- CYP4F12 p.Cys384Trp Uncertain significance Single submitter
- CYP4F12 p.Cys468Tyr Uncertain significance Single submitter
- CYP4F12 p.Glu233Gly Uncertain significance Single submitter
- CYP4F12 p.Glu387Lys Uncertain significance Single submitter
- CYP4F12 p.Gly282Ala Uncertain significance Single submitter
- CYP4F12 p.His147Arg Uncertain significance Single submitter
- CYP4F12 p.His213Arg Uncertain significance Single submitter
- CYP4F12 p.His242Gln Uncertain significance Single submitter
- CYP4F12 p.Ile125Phe Uncertain significance Single submitter
- CYP4F12 p.Ile283Thr Uncertain significance Single submitter
- CYP4F12 p.Ile425Thr Uncertain significance Single submitter
- CYP4F12 p.Leu151Val Uncertain significance Single submitter
- CYP4F12 p.Leu20Pro Uncertain significance Single submitter
- CYP4F12 p.Leu249Phe Uncertain significance Single submitter
- CYP4F12 p.Leu303Pro Uncertain significance Single submitter
- CYP4F12 p.Leu362Arg Uncertain significance Single submitter
- CYP4F12 p.Leu486Pro Uncertain significance Single submitter
- CYP4F12 p.Lys292Met Uncertain significance Single submitter
- CYP4F12 p.Lys56Thr Uncertain significance Single submitter
- CYP4F12 p.Met191Ile Uncertain significance Single submitter
- CYP4F12 p.Met326Leu Uncertain significance Single submitter
- CYP4F12 p.Pro218Ser Uncertain significance Single submitter
- CYP4F12 p.Pro394Ala Uncertain significance Single submitter
- CYP4F12 p.Pro442Ala Uncertain significance Single submitter
- CYP4F12 p.Pro460Leu Uncertain significance Single submitter
- CYP4F12 p.Pro460Ser Uncertain significance Single submitter
- CYP4F12 p.Ser170Asn Uncertain significance Single submitter
- CYP4F12 p.Ser236Arg Uncertain significance Single submitter
- CYP4F12 p.Ser338Phe Uncertain significance Single submitter
- CYP4F12 p.Trp144Cys Uncertain significance Single submitter
- CYP4F12 p.Trp59Arg Uncertain significance Single submitter
- CYP4F12 p.Val358Met Uncertain significance Single submitter
- CYP4F12 p.Val480Ala Uncertain significance Single submitter
- CYP4F12 p.Val481Ala Uncertain significance Single submitter
- CYP4F12 p.Val516Ala Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- CYP4F12 p.Arg146Cys Uncertain significance Single submitter
- CYP4F12 p.Arg149Trp Uncertain significance Single submitter
- CYP4F12 p.Arg255His Uncertain significance Single submitter
- CYP4F12 p.Arg272Trp Uncertain significance Single submitter
- CYP4F12 p.Arg275Cys Uncertain significance Single submitter
- CYP4F12 p.Arg275His Uncertain significance Single submitter
- CYP4F12 p.Arg353Cys Uncertain significance Single submitter
- CYP4F12 p.Arg355Gln Uncertain significance Single submitter
- CYP4F12 p.Arg365Gly Uncertain significance Single submitter
- CYP4F12 p.Arg365His Uncertain significance Single submitter
- CYP4F12 p.Arg500Gly Uncertain significance Single submitter
- CYP4F12 p.Gln241Pro Uncertain significance Single submitter
- CYP4F12 p.Glu352Lys Uncertain significance Single submitter
- CYP4F12 p.Glu517Asp Uncertain significance Single submitter
- CYP4F12 p.Gly310Arg Uncertain significance Single submitter
- CYP4F12 p.Gly452Glu Likely benign Single submitter
- CYP4F12 p.His213Pro Uncertain significance Single submitter
- CYP4F12 p.Ile299Thr Uncertain significance Single submitter
- CYP4F12 p.Leu197Arg Uncertain significance Single submitter
- CYP4F12 p.Leu278Pro Uncertain significance Single submitter
- CYP4F12 p.Phe127Leu Uncertain significance Single submitter
- CYP4F12 p.Pro130His Uncertain significance Single submitter
- CYP4F12 p.Pro394Leu Uncertain significance Single submitter
- CYP4F12 p.Thr324Ser Uncertain significance Single submitter
- CYP4F12 p.Thr333Met Uncertain significance Single submitter
- CYP4F12 p.Tyr163Asn Uncertain significance Single submitter
All CYP4F12 variants
Likely benign 7
- p.Arg146His Single submitter
- p.Arg254Gln Single submitter
- p.Asn343His Single submitter
- p.Gly452Glu Single submitter ⚠
- p.Phe327= Single submitter
- p.Phe98Leu Single submitter
- p.Ser85Pro Single submitter
Uncertain significance 85
- p.Ala472Pro Single submitter ⚠
- p.Ala472Val Single submitter ⚠
- p.Ala474Thr Single submitter ⚠
- p.Arg108Gln Single submitter ⚠
- p.Arg126Lys Single submitter ⚠
- p.Arg146Cys Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Arg188His Single submitter ⚠
- p.Arg255His Single submitter ⚠
- p.Arg261His Single submitter ⚠
- p.Arg272Trp Single submitter ⚠
- p.Arg275Cys Single submitter ⚠
- p.Arg275His Single submitter ⚠
- p.Arg319Thr Single submitter
- p.Arg353Cys Single submitter ⚠
- p.Arg353His Single submitter ⚠
- p.Arg355Gln Single submitter ⚠
- p.Arg365Gly Single submitter ⚠
- p.Arg365His Single submitter ⚠
- p.Arg365Pro Single submitter ⚠
- p.Arg390Thr Single submitter ⚠
- p.Arg412Gln Single submitter ⚠
- p.Arg444Pro Single submitter ⚠
- p.Arg499His Single submitter ⚠
- p.Arg500Gly Single submitter ⚠
- p.Arg507Ser Single submitter ⚠
- p.Arg515Pro Single submitter ⚠
- p.Asn449Ser Single submitter ⚠
- p.Asp201Gly Single submitter ⚠
- p.Asp331Asn Single submitter ⚠
- p.Asp405Glu Single submitter
- p.Asp441Glu Single submitter
- p.Cys214Phe Single submitter
- p.Cys384Trp Single submitter ⚠
- p.Cys468Tyr Single submitter ⚠
- p.Gln241Pro Single submitter ⚠
- p.Glu233Gly Single submitter ⚠
- p.Glu352Lys Single submitter ⚠
- p.Glu387Lys Single submitter ⚠
- p.Glu517Asp Single submitter ⚠
- p.Gly282Ala Single submitter ⚠
- p.Gly310Arg Single submitter ⚠
- p.His147Arg Single submitter ⚠
- p.His213Arg Single submitter ⚠
- p.His213Pro Single submitter ⚠
- p.His242Gln Single submitter ⚠
- p.Ile125Phe Single submitter ⚠
- p.Ile283Thr Single submitter ⚠
- p.Ile299Thr Single submitter ⚠
- p.Ile425Thr Single submitter ⚠
- p.Leu151Val Single submitter ⚠
- p.Leu197Arg Single submitter ⚠
- p.Leu20Pro Single submitter ⚠
- p.Leu249Phe Single submitter ⚠
- p.Leu278Pro Single submitter ⚠
- p.Leu303Pro Single submitter ⚠
- p.Leu362Arg Single submitter ⚠
- p.Leu486Pro Single submitter ⚠
- p.Leu512Phe Single submitter
- p.Lys292Met Single submitter ⚠
- p.Lys56Thr Single submitter ⚠
- p.Met191Ile Single submitter ⚠
- p.Met326Leu Single submitter ⚠
- p.Met506Lys Single submitter
- p.Phe127Leu Single submitter ⚠
- p.Pro130His Single submitter ⚠
- p.Pro218Ser Single submitter ⚠
- p.Pro394Ala Single submitter ⚠
- p.Pro394Leu Single submitter ⚠
- p.Pro442Ala Single submitter ⚠
- p.Pro460Leu Single submitter ⚠
- p.Pro460Ser Single submitter ⚠
- p.Ser170Asn Single submitter ⚠
- p.Ser236Arg Single submitter ⚠
- p.Ser338Phe Single submitter ⚠
- p.Thr324Ser Single submitter ⚠
- p.Thr333Met Single submitter ⚠
- p.Trp144Cys Single submitter ⚠
- p.Trp59Arg Single submitter ⚠
- p.Tyr163Asn Single submitter ⚠
- p.Val358Met Single submitter ⚠
- p.Val433Ala Single submitter
- p.Val480Ala Single submitter ⚠
- p.Val481Ala Single submitter ⚠
- p.Val516Ala Single submitter ⚠