CYP4F3 — 114 ClinVar variants
All ClinVar germline CYP4F3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 97 flagged for review →
4 Benign · 1 Benign/Likely benign · 9 Likely benign · 100 Uncertain significance
Full CYP4F3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 97
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP4F3 p.Ala291Asp Uncertain significance Single submitter
- CYP4F3 p.Ala432Asp Uncertain significance Single submitter
- CYP4F3 p.Arg507Gly Uncertain significance Single submitter
- CYP4F3 p.Asp121Tyr Uncertain significance Single submitter
- CYP4F3 p.Asp265Glu Uncertain significance Single submitter
- CYP4F3 p.Asp300Val Uncertain significance Single submitter
- CYP4F3 p.Asp373Glu Uncertain significance Single submitter
- CYP4F3 p.Asp405Ala Uncertain significance Single submitter
- CYP4F3 p.Cys206Arg Uncertain significance Single submitter
- CYP4F3 p.Cys402Phe Uncertain significance Single submitter
- CYP4F3 p.Glu357Asp Uncertain significance Single submitter
- CYP4F3 p.Glu387Asp Uncertain significance Single submitter
- CYP4F3 p.Gly282Asp Uncertain significance Single submitter
- CYP4F3 p.Gly426Arg Uncertain significance Single submitter
- CYP4F3 p.His175Leu Uncertain significance Single submitter
- CYP4F3 p.His63Leu Uncertain significance Single submitter
- CYP4F3 p.Leu128Pro Uncertain significance Single submitter
- CYP4F3 p.Leu138Pro Uncertain significance Single submitter
- CYP4F3 p.Leu421Phe Uncertain significance Single submitter
- CYP4F3 p.Lys479Met Uncertain significance Single submitter
- CYP4F3 p.Phe157Leu Uncertain significance Single submitter
- CYP4F3 p.Pro18Leu Uncertain significance Single submitter
- CYP4F3 p.Pro442Leu Uncertain significance Single submitter
- CYP4F3 p.Pro442Thr Uncertain significance Single submitter
- CYP4F3 p.Pro460Ser Uncertain significance Single submitter
- CYP4F3 p.Ser209Arg Uncertain significance Single submitter
- CYP4F3 p.Ser229Arg Uncertain significance Single submitter
- CYP4F3 p.Ser8Leu Uncertain significance Single submitter
- CYP4F3 p.Thr485Arg Uncertain significance Single submitter
- CYP4F3 p.Thr485Lys Uncertain significance Single submitter
- CYP4F3 p.Thr496Ser Uncertain significance Single submitter
- CYP4F3 p.Thr83Ile Uncertain significance Single submitter
- CYP4F3 p.Val25Ala Uncertain significance Single submitter
Predictors split 64
The independent predictors disagree with each other — read with care.
- CYP4F3 p.Val270Ile Benign/Likely benign Multiple submitters
- CYP4F3 p.Ala259Val Uncertain significance Single submitter
- CYP4F3 p.Arg146Cys Uncertain significance Single submitter
- CYP4F3 p.Arg149Leu Uncertain significance Single submitter
- CYP4F3 p.Arg149Trp Uncertain significance Single submitter
- CYP4F3 p.Arg188His Uncertain significance Single submitter
- CYP4F3 p.Arg255His Uncertain significance Single submitter
- CYP4F3 p.Arg274Trp Uncertain significance Single submitter
- CYP4F3 p.Arg275Cys Uncertain significance Single submitter
- CYP4F3 p.Arg353Cys Uncertain significance Single submitter
- CYP4F3 p.Arg353His Uncertain significance Single submitter
- CYP4F3 p.Arg353Leu Uncertain significance Single submitter
- CYP4F3 p.Arg355Gln Uncertain significance Single submitter
- CYP4F3 p.Arg355Trp Uncertain significance Single submitter
- CYP4F3 p.Arg365Cys Uncertain significance Single submitter
- CYP4F3 p.Arg400His Uncertain significance Single submitter
- CYP4F3 p.Arg47His Likely benign Single submitter
- CYP4F3 p.Arg47Leu Uncertain significance Single submitter
- CYP4F3 p.Arg490Cys Uncertain significance Single submitter
- CYP4F3 p.Arg57Gln Uncertain significance Single submitter
- CYP4F3 p.Arg57Leu Uncertain significance Single submitter
- CYP4F3 p.Arg57Trp Uncertain significance Single submitter
- CYP4F3 p.Asn449Ile Uncertain significance Single submitter
- CYP4F3 p.Asp134Asn Uncertain significance Single submitter
- CYP4F3 p.Asp374Asn Uncertain significance Single submitter
- CYP4F3 p.Asp374Val Uncertain significance Single submitter
- CYP4F3 p.Cys420Gly Uncertain significance Single submitter
- CYP4F3 p.Gln404Arg Uncertain significance Single submitter
- CYP4F3 p.Glu371Lys Uncertain significance Single submitter
- CYP4F3 p.Glu477Lys Uncertain significance Single submitter
- CYP4F3 p.Glu497Lys Uncertain significance Single submitter
- CYP4F3 p.Glu509Gly Uncertain significance Single submitter
- CYP4F3 p.Glu517Gln Uncertain significance Single submitter
- CYP4F3 p.Gly253Ala Uncertain significance Single submitter
- CYP4F3 p.Gly411Arg Uncertain significance Single submitter
- CYP4F3 p.His347Arg Uncertain significance Single submitter
- CYP4F3 p.Ile318Met Uncertain significance Single submitter
- CYP4F3 p.Ile318Val Uncertain significance Single submitter
- CYP4F3 p.Ile406Phe Uncertain significance Single submitter
- CYP4F3 p.Ile406Thr Uncertain significance Single submitter
- CYP4F3 p.Leu241Pro Uncertain significance Single submitter
- CYP4F3 p.Leu313Phe Uncertain significance Single submitter
- CYP4F3 p.Met164Arg Uncertain significance Single submitter
- CYP4F3 p.Met478Val Uncertain significance Single submitter
- CYP4F3 p.Phe425Ser Uncertain significance Single submitter
- CYP4F3 p.Pro279Thr Uncertain significance Single submitter
- CYP4F3 p.Pro431Thr Uncertain significance Single submitter
- CYP4F3 p.Pro518Ala Uncertain significance Single submitter
- CYP4F3 p.Pro518Ser Uncertain significance Single submitter
- CYP4F3 p.Pro52Leu Uncertain significance Single submitter
- CYP4F3 p.Pro54Leu Uncertain significance Single submitter
- CYP4F3 p.Pro55Arg Uncertain significance Single submitter
- CYP4F3 p.Ser399Cys Uncertain significance Single submitter
- CYP4F3 p.Ser462Leu Uncertain significance Single submitter
- CYP4F3 p.Thr152Pro Uncertain significance Single submitter
- CYP4F3 p.Thr382Ala Uncertain significance Single submitter
- CYP4F3 p.Tyr247Cys Uncertain significance Single submitter
- CYP4F3 p.Tyr342Asn Uncertain significance Single submitter
- CYP4F3 p.Tyr39His Uncertain significance Single submitter
- CYP4F3 p.Val232Leu Uncertain significance Single submitter
- CYP4F3 p.Val398Ala Uncertain significance Single submitter
- CYP4F3 p.Val424Ala Uncertain significance Single submitter
- CYP4F3 p.Arg275His Uncertain significance No assertion criteria
- CYP4F3 p.Leu375Val Uncertain significance No assertion criteria
All CYP4F3 variants
Benign 4
- c.1398-10C>T Multiple submitters
- p.Met191Val Multiple submitters
- p.Val398Ile Multiple submitters
- p.Asp436= Single submitter
Benign/Likely benign 1
- p.Val270Ile Multiple submitters ⚠
Likely benign 9
- p.Ile173= Multiple submitters
- c.199-1695A>C Single submitter
- c.199-1719G>A Single submitter
- p.Arg47His Single submitter ⚠
- p.Gln288Lys Single submitter
- p.Ile271Thr Single submitter
- p.Lys448Glu Single submitter
- p.Thr333= Single submitter
- p.Val118Ala Single submitter
Uncertain significance 100
- c.199-1688G>A Single submitter
- c.199-1695A>T Single submitter
- c.199-1709T>G Single submitter
- c.199-1712G>A Single submitter
- c.199-1760A>T Single submitter
- p.Ala259Val Single submitter ⚠
- p.Ala291Asp Single submitter ⚠
- p.Ala432Asp Single submitter ⚠
- p.Arg146Cys Single submitter ⚠
- p.Arg149Leu Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Arg188His Single submitter ⚠
- p.Arg255His Single submitter ⚠
- p.Arg274Trp Single submitter ⚠
- p.Arg275Cys Single submitter ⚠
- p.Arg353Cys Single submitter ⚠
- p.Arg353His Single submitter ⚠
- p.Arg353Leu Single submitter ⚠
- p.Arg355Gln Single submitter ⚠
- p.Arg355Trp Single submitter ⚠
- p.Arg365Cys Single submitter ⚠
- p.Arg400His Single submitter ⚠
- p.Arg47Leu Single submitter ⚠
- p.Arg490Cys Single submitter ⚠
- p.Arg507Gly Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg57Leu Single submitter ⚠
- p.Arg57Trp Single submitter ⚠
- p.Asn449Ile Single submitter ⚠
- p.Asp121Tyr Single submitter ⚠
- p.Asp134Asn Single submitter ⚠
- p.Asp265Glu Single submitter ⚠
- p.Asp300Val Single submitter ⚠
- p.Asp373Glu Single submitter ⚠
- p.Asp374Asn Single submitter ⚠
- p.Asp374Val Single submitter ⚠
- p.Asp405Ala Single submitter ⚠
- p.Cys206Arg Single submitter ⚠
- p.Cys402Phe Single submitter ⚠
- p.Cys420Gly Single submitter ⚠
- p.Gln404Arg Single submitter ⚠
- p.Glu357Asp Single submitter ⚠
- p.Glu371Lys Single submitter ⚠
- p.Glu387Asp Single submitter ⚠
- p.Glu477Lys Single submitter ⚠
- p.Glu497Lys Single submitter ⚠
- p.Glu509Gly Single submitter ⚠
- p.Glu517Gln Single submitter ⚠
- p.Gly253Ala Single submitter ⚠
- p.Gly282Asp Single submitter ⚠
- p.Gly411Arg Single submitter ⚠
- p.Gly426Arg Single submitter ⚠
- p.His175Leu Single submitter ⚠
- p.His347Arg Single submitter ⚠
- p.His63Leu Single submitter ⚠
- p.Ile318Met Single submitter ⚠
- p.Ile318Val Single submitter ⚠
- p.Ile406Phe Single submitter ⚠
- p.Ile406Thr Single submitter ⚠
- p.Leu128Pro Single submitter ⚠
- p.Leu138Pro Single submitter ⚠
- p.Leu241Pro Single submitter ⚠
- p.Leu313Phe Single submitter ⚠
- p.Leu421Phe Single submitter ⚠
- p.Lys479Met Single submitter ⚠
- p.Met164Arg Single submitter ⚠
- p.Met478Val Single submitter ⚠
- p.Phe157Leu Single submitter ⚠
- p.Phe425Ser Single submitter ⚠
- p.Pro18Leu Single submitter ⚠
- p.Pro279Thr Single submitter ⚠
- p.Pro431Thr Single submitter ⚠
- p.Pro442Leu Single submitter ⚠
- p.Pro442Thr Single submitter ⚠
- p.Pro460Ser Single submitter ⚠
- p.Pro518Ala Single submitter ⚠
- p.Pro518Ser Single submitter ⚠
- p.Pro52Leu Single submitter ⚠
- p.Pro54Leu Single submitter ⚠
- p.Pro55Arg Single submitter ⚠
- p.Ser209Arg Single submitter ⚠
- p.Ser229Arg Single submitter ⚠
- p.Ser399Cys Single submitter ⚠
- p.Ser462Leu Single submitter ⚠
- p.Ser8Leu Single submitter ⚠
- p.Thr152Pro Single submitter ⚠
- p.Thr382Ala Single submitter ⚠
- p.Thr485Arg Single submitter ⚠
- p.Thr485Lys Single submitter ⚠
- p.Thr496Ser Single submitter ⚠
- p.Thr83Ile Single submitter ⚠
- p.Tyr247Cys Single submitter ⚠
- p.Tyr342Asn Single submitter ⚠
- p.Tyr39His Single submitter ⚠
- p.Val232Leu Single submitter ⚠
- p.Val25Ala Single submitter ⚠
- p.Val398Ala Single submitter ⚠
- p.Val424Ala Single submitter ⚠
- p.Arg275His No assertion criteria ⚠
- p.Leu375Val No assertion criteria ⚠