CYP4F8 — 57 ClinVar variants
All ClinVar germline CYP4F8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
6 Likely benign · 51 Uncertain significance
Full CYP4F8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP4F8 p.Ala40Asp Uncertain significance Single submitter
- CYP4F8 p.Arg108Gln Uncertain significance Single submitter
- CYP4F8 p.Arg241Gln Uncertain significance Single submitter
- CYP4F8 p.Arg55Gln Uncertain significance Single submitter
- CYP4F8 p.Glu321Gly Uncertain significance Single submitter
- CYP4F8 p.Gly135Trp Uncertain significance Single submitter
- CYP4F8 p.Gly336Ser Uncertain significance Single submitter
- CYP4F8 p.His43Arg Uncertain significance Single submitter
- CYP4F8 p.Leu132Pro Uncertain significance Single submitter
- CYP4F8 p.Leu64Val Uncertain significance Single submitter
- CYP4F8 p.Lys311Gln Uncertain significance Single submitter
- CYP4F8 p.Pro18Arg Uncertain significance Single submitter
- CYP4F8 p.Ser7Pro Uncertain significance Single submitter
- CYP4F8 p.Thr277Ile Uncertain significance Single submitter
- CYP4F8 p.Trp37Arg Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- CYP4F8 p.Ala269Val Uncertain significance Single submitter
- CYP4F8 p.Arg145Ile Uncertain significance Single submitter
- CYP4F8 p.Arg148Cys Likely benign Single submitter
- CYP4F8 p.Arg149Cys Likely benign Single submitter
- CYP4F8 p.Arg149His Likely benign Single submitter
- CYP4F8 p.Arg254Gln Likely benign Single submitter
- CYP4F8 p.Arg33His Uncertain significance Single submitter
- CYP4F8 p.Arg46Cys Uncertain significance Single submitter
- CYP4F8 p.Arg46His Uncertain significance Single submitter
- CYP4F8 p.Arg47Cys Uncertain significance Single submitter
- CYP4F8 p.Arg47His Uncertain significance Single submitter
- CYP4F8 p.Asn423Asp Uncertain significance Single submitter
- CYP4F8 p.Asp105Glu Uncertain significance Single submitter
- CYP4F8 p.Asp134Tyr Uncertain significance Single submitter
- CYP4F8 p.Asp134Val Uncertain significance Single submitter
- CYP4F8 p.Asp364Glu Uncertain significance Single submitter
- CYP4F8 p.Gln53Lys Uncertain significance Single submitter
- CYP4F8 p.Gln86Lys Uncertain significance Single submitter
- CYP4F8 p.Gly141Asp Uncertain significance Single submitter
- CYP4F8 p.Gly26Glu Uncertain significance Single submitter
- CYP4F8 p.Gly282Cys Uncertain significance Single submitter
- CYP4F8 p.Gly310Arg Uncertain significance Single submitter
- CYP4F8 p.Gly87Val Uncertain significance Single submitter
- CYP4F8 p.Leu11Phe Uncertain significance Single submitter
- CYP4F8 p.Leu136Ile Uncertain significance Single submitter
- CYP4F8 p.Lys161Glu Uncertain significance Single submitter
- CYP4F8 p.Phe124Leu Uncertain significance Single submitter
- CYP4F8 p.Phe298Ser Uncertain significance Single submitter
- CYP4F8 p.Phe51Leu Uncertain significance Single submitter
- CYP4F8 p.Pro162Leu Uncertain significance Single submitter
- CYP4F8 p.Pro218Leu Uncertain significance Single submitter
- CYP4F8 p.Pro52Leu Uncertain significance Single submitter
- CYP4F8 p.Pro54His Uncertain significance Single submitter
- CYP4F8 p.Pro94Ser Uncertain significance Single submitter
- CYP4F8 p.Pro97Ser Uncertain significance Single submitter
- CYP4F8 p.Tyr42Cys Uncertain significance Single submitter
- CYP4F8 p.Tyr84Cys Uncertain significance Single submitter
- CYP4F8 p.Val24Met Uncertain significance Single submitter
- CYP4F8 p.Val25Ile Uncertain significance Single submitter
- CYP4F8 p.Val25Phe Uncertain significance Single submitter
All CYP4F8 variants
Likely benign 6
- p.Arg148Cys Single submitter ⚠
- p.Arg149Cys Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Arg254Gln Single submitter ⚠
- p.Arg49Gln Single submitter
- p.Ser2Leu Single submitter
Uncertain significance 51
- p.Ala269Val Single submitter ⚠
- p.Ala40Asp Single submitter ⚠
- p.Arg108Gln Single submitter ⚠
- p.Arg145Ile Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg33His Single submitter ⚠
- p.Arg46Cys Single submitter ⚠
- p.Arg46His Single submitter ⚠
- p.Arg47Cys Single submitter ⚠
- p.Arg47His Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Asn423Asp Single submitter ⚠
- p.Asp105Glu Single submitter ⚠
- p.Asp134Tyr Single submitter ⚠
- p.Asp134Val Single submitter ⚠
- p.Asp364Glu Single submitter ⚠
- p.Gln53Lys Single submitter ⚠
- p.Gln86Lys Single submitter ⚠
- p.Glu321Gly Single submitter ⚠
- p.Gly135Trp Single submitter ⚠
- p.Gly141Asp Single submitter ⚠
- p.Gly26Glu Single submitter ⚠
- p.Gly282Cys Single submitter ⚠
- p.Gly310Arg Single submitter ⚠
- p.Gly336Ser Single submitter ⚠
- p.Gly87Val Single submitter ⚠
- p.His43Arg Single submitter ⚠
- p.Leu11Phe Single submitter ⚠
- p.Leu132Pro Single submitter ⚠
- p.Leu136Ile Single submitter ⚠
- p.Leu64Val Single submitter ⚠
- p.Lys161Glu Single submitter ⚠
- p.Lys311Gln Single submitter ⚠
- p.Phe124Leu Single submitter ⚠
- p.Phe298Ser Single submitter ⚠
- p.Phe51Leu Single submitter ⚠
- p.Pro162Leu Single submitter ⚠
- p.Pro18Arg Single submitter ⚠
- p.Pro218Leu Single submitter ⚠
- p.Pro52Leu Single submitter ⚠
- p.Pro54His Single submitter ⚠
- p.Pro94Ser Single submitter ⚠
- p.Pro97Ser Single submitter ⚠
- p.Ser7Pro Single submitter ⚠
- p.Thr277Ile Single submitter ⚠
- p.Trp37Arg Single submitter ⚠
- p.Tyr42Cys Single submitter ⚠
- p.Tyr84Cys Single submitter ⚠
- p.Val24Met Single submitter ⚠
- p.Val25Ile Single submitter ⚠
- p.Val25Phe Single submitter ⚠