CYP4X1 — 76 ClinVar variants
All ClinVar germline CYP4X1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
5 Likely benign · 71 Uncertain significance
Full CYP4X1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP4X1 p.Ala11Val Uncertain significance Single submitter
- CYP4X1 p.Ala402Thr Uncertain significance Single submitter
- CYP4X1 p.Ala99Gly Uncertain significance Single submitter
- CYP4X1 p.Ala99Val Uncertain significance Single submitter
- CYP4X1 p.Arg246Cys Uncertain significance Single submitter
- CYP4X1 p.Arg265Ile Uncertain significance Single submitter
- CYP4X1 p.Arg281Lys Uncertain significance Single submitter
- CYP4X1 p.Arg41Gln Uncertain significance Single submitter
- CYP4X1 p.Arg483Ser Uncertain significance Single submitter
- CYP4X1 p.Asp387Gly Uncertain significance Single submitter
- CYP4X1 p.Cys21Ser Uncertain significance Single submitter
- CYP4X1 p.Gln174Glu Uncertain significance Single submitter
- CYP4X1 p.Gln248Arg Uncertain significance Single submitter
- CYP4X1 p.Gln58His Uncertain significance Single submitter
- CYP4X1 p.Glu154Lys Uncertain significance Single submitter
- CYP4X1 p.Glu7Ala Uncertain significance Single submitter
- CYP4X1 p.Gly456Arg Uncertain significance Single submitter
- CYP4X1 p.Gly56Val Uncertain significance Single submitter
- CYP4X1 p.His209Pro Uncertain significance Single submitter
- CYP4X1 p.His502Tyr Uncertain significance Single submitter
- CYP4X1 p.Ile30Leu Uncertain significance Single submitter
- CYP4X1 p.Ile410Met Uncertain significance Single submitter
- CYP4X1 p.Ile462Thr Uncertain significance Single submitter
- CYP4X1 p.Leu24Val Uncertain significance Single submitter
- CYP4X1 p.Leu334Val Uncertain significance Single submitter
- CYP4X1 p.Leu413Ile Uncertain significance Single submitter
- CYP4X1 p.Lys109Asn Uncertain significance Single submitter
- CYP4X1 p.Lys282Arg Uncertain significance Single submitter
- CYP4X1 p.Lys496Arg Uncertain significance Single submitter
- CYP4X1 p.Met66Val Uncertain significance Single submitter
- CYP4X1 p.Phe146Cys Uncertain significance Single submitter
- CYP4X1 p.Phe238Ser Uncertain significance Single submitter
- CYP4X1 p.Phe431Leu Uncertain significance Single submitter
- CYP4X1 p.Pro13Ala Uncertain significance Single submitter
- CYP4X1 p.Pro279Leu Uncertain significance Single submitter
- CYP4X1 p.Ser172Asn Uncertain significance Single submitter
- CYP4X1 p.Ser177Asn Uncertain significance Single submitter
- CYP4X1 p.Ser207Arg Uncertain significance Single submitter
- CYP4X1 p.Ser220Cys Uncertain significance Single submitter
- CYP4X1 p.Ser297Gly Uncertain significance Single submitter
- CYP4X1 p.Ser308Pro Uncertain significance Single submitter
- CYP4X1 p.Ser409Gly Uncertain significance Single submitter
- CYP4X1 p.Ser4Pro Uncertain significance Single submitter
- CYP4X1 p.Thr278Pro Uncertain significance Single submitter
- CYP4X1 p.Thr357Ala Uncertain significance Single submitter
- CYP4X1 p.Thr405Ala Uncertain significance Single submitter
- CYP4X1 p.Tyr33His Uncertain significance Single submitter
- CYP4X1 p.Tyr94Cys Uncertain significance Single submitter
- CYP4X1 p.Val178Met Uncertain significance Single submitter
- CYP4X1 p.Val306Ile Uncertain significance Single submitter
- CYP4X1 p.Val346Gly Uncertain significance Single submitter
- CYP4X1 p.Val407Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CYP4X1 p.Arg343Trp Uncertain significance Single submitter
- CYP4X1 p.Gly298Asp Uncertain significance Single submitter
- CYP4X1 p.His440Gln Uncertain significance Single submitter
- CYP4X1 p.His52Leu Uncertain significance Single submitter
- CYP4X1 p.Ile349Met Uncertain significance Single submitter
- CYP4X1 p.Ile455Thr Uncertain significance Single submitter
- CYP4X1 p.Leu472Val Uncertain significance Single submitter
- CYP4X1 p.Pro77Ala Uncertain significance Single submitter
- CYP4X1 p.Ser220Arg Uncertain significance Single submitter
- CYP4X1 p.Ser432Phe Uncertain significance Single submitter
- CYP4X1 p.Ser436Pro Uncertain significance Single submitter
- CYP4X1 p.Thr374Met Uncertain significance Single submitter
- CYP4X1 p.Thr467Asn Uncertain significance Single submitter
- CYP4X1 p.Val477Met Uncertain significance Single submitter
All CYP4X1 variants
Likely benign 5
- p.Ile261Val Single submitter
- p.Leu102Phe Single submitter
- p.Leu485Pro Single submitter
- p.Lys249Glu Single submitter
- p.Val381Ile Single submitter
Uncertain significance 71
- p.Ala11Val Single submitter ⚠
- p.Ala402Thr Single submitter ⚠
- p.Ala99Gly Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg226Cys Single submitter
- p.Arg246Cys Single submitter ⚠
- p.Arg265Ile Single submitter ⚠
- p.Arg281Lys Single submitter ⚠
- p.Arg343Trp Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg439Gly Single submitter
- p.Arg483Ser Single submitter ⚠
- p.Asp387Gly Single submitter ⚠
- p.Cys21Ser Single submitter ⚠
- p.Gln174Glu Single submitter ⚠
- p.Gln248Arg Single submitter ⚠
- p.Gln58His Single submitter ⚠
- p.Glu154Lys Single submitter ⚠
- p.Glu7Ala Single submitter ⚠
- p.Gly298Asp Single submitter ⚠
- p.Gly456Arg Single submitter ⚠
- p.Gly56Val Single submitter ⚠
- p.His209Pro Single submitter ⚠
- p.His440Gln Single submitter ⚠
- p.His502Tyr Single submitter ⚠
- p.His52Leu Single submitter ⚠
- p.Ile184Thr Single submitter
- p.Ile30Leu Single submitter ⚠
- p.Ile349Met Single submitter ⚠
- p.Ile410Met Single submitter ⚠
- p.Ile455Thr Single submitter ⚠
- p.Ile462Thr Single submitter ⚠
- p.Leu22Gln Single submitter
- p.Leu24Val Single submitter ⚠
- p.Leu334Val Single submitter ⚠
- p.Leu413Ile Single submitter ⚠
- p.Leu472Val Single submitter ⚠
- p.Lys109Asn Single submitter ⚠
- p.Lys282Arg Single submitter ⚠
- p.Lys496Arg Single submitter ⚠
- p.Met1Thr Single submitter
- p.Met66Val Single submitter ⚠
- p.Phe146Cys Single submitter ⚠
- p.Phe238Ser Single submitter ⚠
- p.Phe431Leu Single submitter ⚠
- p.Pro13Ala Single submitter ⚠
- p.Pro279Leu Single submitter ⚠
- p.Pro77Ala Single submitter ⚠
- p.Ser172Asn Single submitter ⚠
- p.Ser177Asn Single submitter ⚠
- p.Ser207Arg Single submitter ⚠
- p.Ser220Arg Single submitter ⚠
- p.Ser220Cys Single submitter ⚠
- p.Ser297Gly Single submitter ⚠
- p.Ser308Pro Single submitter ⚠
- p.Ser409Gly Single submitter ⚠
- p.Ser432Phe Single submitter ⚠
- p.Ser436Pro Single submitter ⚠
- p.Ser4Pro Single submitter ⚠
- p.Thr278Pro Single submitter ⚠
- p.Thr357Ala Single submitter ⚠
- p.Thr374Met Single submitter ⚠
- p.Thr405Ala Single submitter ⚠
- p.Thr467Asn Single submitter ⚠
- p.Tyr33His Single submitter ⚠
- p.Tyr94Cys Single submitter ⚠
- p.Val178Met Single submitter ⚠
- p.Val306Ile Single submitter ⚠
- p.Val346Gly Single submitter ⚠
- p.Val407Ala Single submitter ⚠
- p.Val477Met Single submitter ⚠