CYP4Z1 — 77 ClinVar variants
All ClinVar germline CYP4Z1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Benign · 8 Likely benign · 68 Uncertain significance
Full CYP4Z1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYP4Z1 p.Ala99Val Uncertain significance Single submitter
- CYP4Z1 p.Arg161Gln Uncertain significance Single submitter
- CYP4Z1 p.Arg41Ser Uncertain significance Single submitter
- CYP4Z1 p.Arg472His Uncertain significance Single submitter
- CYP4Z1 p.Arg481Ser Uncertain significance Single submitter
- CYP4Z1 p.Arg487His Uncertain significance Single submitter
- CYP4Z1 p.Asn217His Uncertain significance Single submitter
- CYP4Z1 p.Asn250Ser Uncertain significance Single submitter
- CYP4Z1 p.Asp387Asn Uncertain significance Single submitter
- CYP4Z1 p.Gln242Lys Uncertain significance Single submitter
- CYP4Z1 p.Glu178Lys Uncertain significance Single submitter
- CYP4Z1 p.Glu371Lys Uncertain significance Single submitter
- CYP4Z1 p.Glu461Gly Uncertain significance Single submitter
- CYP4Z1 p.Gly122Asp Uncertain significance Single submitter
- CYP4Z1 p.Gly315Arg Uncertain significance Single submitter
- CYP4Z1 p.Gly401Val Uncertain significance Single submitter
- CYP4Z1 p.His170Asn Uncertain significance Single submitter
- CYP4Z1 p.His231Tyr Uncertain significance Single submitter
- CYP4Z1 p.His456Arg Uncertain significance Single submitter
- CYP4Z1 p.His479Tyr Uncertain significance Single submitter
- CYP4Z1 p.Ile369Thr Uncertain significance Single submitter
- CYP4Z1 p.Ile459Val Uncertain significance Single submitter
- CYP4Z1 p.Leu125Pro Uncertain significance Single submitter
- CYP4Z1 p.Leu253Phe Uncertain significance Single submitter
- CYP4Z1 p.Leu449Ile Uncertain significance Single submitter
- CYP4Z1 p.Lys104Thr Uncertain significance Single submitter
- CYP4Z1 p.Lys193Arg Uncertain significance Single submitter
- CYP4Z1 p.Lys71Arg Uncertain significance Single submitter
- CYP4Z1 p.Met155Thr Uncertain significance Single submitter
- CYP4Z1 p.Met186Ile Uncertain significance Single submitter
- CYP4Z1 p.Met226Ile Uncertain significance Single submitter
- CYP4Z1 p.Met39Thr Uncertain significance Single submitter
- CYP4Z1 p.Phe249Ser Uncertain significance Single submitter
- CYP4Z1 p.Ser267Phe Uncertain significance Single submitter
- CYP4Z1 p.Ser290Arg Uncertain significance Single submitter
- CYP4Z1 p.Ser293Asn Uncertain significance Single submitter
- CYP4Z1 p.Trp133Arg Uncertain significance Single submitter
- CYP4Z1 p.Val308Leu Uncertain significance Single submitter
- CYP4Z1 p.Val404Gly Uncertain significance Single submitter
- CYP4Z1 p.Val84Asp Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CYP4Z1 p.Ala214Thr Uncertain significance Single submitter
- CYP4Z1 p.Ala467Thr Uncertain significance Single submitter
- CYP4Z1 p.Arg225Cys Uncertain significance Single submitter
- CYP4Z1 p.Arg225Ser Uncertain significance Single submitter
- CYP4Z1 p.Arg264Trp Uncertain significance Single submitter
- CYP4Z1 p.Arg281Cys Uncertain significance Single submitter
- CYP4Z1 p.Arg384Trp Uncertain significance Single submitter
- CYP4Z1 p.Arg396Cys Uncertain significance Single submitter
- CYP4Z1 p.Asn433Ser Uncertain significance Single submitter
- CYP4Z1 p.His170Pro Uncertain significance Single submitter
- CYP4Z1 p.His438Arg Uncertain significance Single submitter
- CYP4Z1 p.Ile382Met Uncertain significance Single submitter
- CYP4Z1 p.Ile443Thr Uncertain significance Single submitter
- CYP4Z1 p.Ile459Thr Uncertain significance Single submitter
- CYP4Z1 p.Leu17Pro Uncertain significance Single submitter
- CYP4Z1 p.Leu330Phe Uncertain significance Single submitter
- CYP4Z1 p.Leu375Phe Uncertain significance Single submitter
- CYP4Z1 p.Lys75Asn Uncertain significance Single submitter
- CYP4Z1 p.Met192Thr Uncertain significance Single submitter
- CYP4Z1 p.Phe246Cys Uncertain significance Single submitter
- CYP4Z1 p.Pro13Arg Uncertain significance Single submitter
- CYP4Z1 p.Pro421Arg Uncertain significance Single submitter
- CYP4Z1 p.Ser206Cys Uncertain significance Single submitter
- CYP4Z1 p.Ser219Asn Uncertain significance Single submitter
- CYP4Z1 p.Ser4Cys Uncertain significance Single submitter
- CYP4Z1 p.Thr310Met Uncertain significance Single submitter
- CYP4Z1 p.Thr365Ala Uncertain significance Single submitter
- CYP4Z1 p.Val464Met Uncertain significance Single submitter
All CYP4Z1 variants
Benign 1
- p.Arg281His Multiple submitters
Likely benign 8
- p.Arg176Cys Single submitter
- p.Gln181Glu Single submitter
- p.Glu266Lys Single submitter
- p.Leu491= Single submitter
- p.Met22Leu Single submitter
- p.Phe27Leu Single submitter
- p.Ser293= Single submitter
- p.Trp38Arg Single submitter
Uncertain significance 68
- p.Ala214Thr Single submitter ⚠
- p.Ala467Thr Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg161Gln Single submitter ⚠
- p.Arg225Cys Single submitter ⚠
- p.Arg225Ser Single submitter ⚠
- p.Arg264Trp Single submitter ⚠
- p.Arg281Cys Single submitter ⚠
- p.Arg384Trp Single submitter ⚠
- p.Arg396Cys Single submitter ⚠
- p.Arg41Ser Single submitter ⚠
- p.Arg472His Single submitter ⚠
- p.Arg481Ser Single submitter ⚠
- p.Arg487His Single submitter ⚠
- p.Asn217His Single submitter ⚠
- p.Asn250Ser Single submitter ⚠
- p.Asn433Ser Single submitter ⚠
- p.Asp387Asn Single submitter ⚠
- p.Gln242Lys Single submitter ⚠
- p.Glu178Lys Single submitter ⚠
- p.Glu371Lys Single submitter ⚠
- p.Glu461Gly Single submitter ⚠
- p.Gly122Asp Single submitter ⚠
- p.Gly315Arg Single submitter ⚠
- p.Gly401Val Single submitter ⚠
- p.His170Asn Single submitter ⚠
- p.His170Pro Single submitter ⚠
- p.His231Tyr Single submitter ⚠
- p.His438Arg Single submitter ⚠
- p.His456Arg Single submitter ⚠
- p.His479Tyr Single submitter ⚠
- p.Ile369Thr Single submitter ⚠
- p.Ile382Met Single submitter ⚠
- p.Ile443Thr Single submitter ⚠
- p.Ile459Thr Single submitter ⚠
- p.Ile459Val Single submitter ⚠
- p.Leu125Pro Single submitter ⚠
- p.Leu17Pro Single submitter ⚠
- p.Leu253Phe Single submitter ⚠
- p.Leu330Phe Single submitter ⚠
- p.Leu375Phe Single submitter ⚠
- p.Leu449Ile Single submitter ⚠
- p.Lys104Thr Single submitter ⚠
- p.Lys193Arg Single submitter ⚠
- p.Lys71Arg Single submitter ⚠
- p.Lys75Asn Single submitter ⚠
- p.Met155Thr Single submitter ⚠
- p.Met186Ile Single submitter ⚠
- p.Met192Thr Single submitter ⚠
- p.Met226Ile Single submitter ⚠
- p.Met39Thr Single submitter ⚠
- p.Phe246Cys Single submitter ⚠
- p.Phe249Ser Single submitter ⚠
- p.Pro13Arg Single submitter ⚠
- p.Pro421Arg Single submitter ⚠
- p.Ser206Cys Single submitter ⚠
- p.Ser219Asn Single submitter ⚠
- p.Ser267Phe Single submitter ⚠
- p.Ser290Arg Single submitter ⚠
- p.Ser293Asn Single submitter ⚠
- p.Ser4Cys Single submitter ⚠
- p.Thr310Met Single submitter ⚠
- p.Thr365Ala Single submitter ⚠
- p.Trp133Arg Single submitter ⚠
- p.Val308Leu Single submitter ⚠
- p.Val404Gly Single submitter ⚠
- p.Val464Met Single submitter ⚠
- p.Val84Asp Single submitter ⚠