CYRIB — 12 ClinVar variants
All ClinVar germline CYRIB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
12 Uncertain significance
Full CYRIB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYRIB p.Arg105Gly Uncertain significance Single submitter
- CYRIB p.Arg105Ser Uncertain significance Single submitter
- CYRIB p.Arg124Gln Uncertain significance Single submitter
- CYRIB p.Ser31Pro Uncertain significance Single submitter
- CYRIB p.Thr29Ala Uncertain significance Single submitter
- CYRIB p.Trp80Arg Uncertain significance Single submitter
- CYRIB p.Val41Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CYRIB variants
Uncertain significance 12
- p.Arg105Gly Single submitter ⚠
- p.Arg105Ser Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Gly175Arg Single submitter ⚠
- p.Pro70Ala Single submitter
- p.Ser31Pro Single submitter ⚠
- p.Thr112Ala Single submitter ⚠
- p.Thr29Ala Single submitter ⚠
- p.Trp80Arg Single submitter ⚠
- p.Tyr36Cys Single submitter
- p.Val270Leu Single submitter ⚠
- p.Val41Ala Single submitter ⚠