CYSLTR1 — 41 ClinVar variants
All ClinVar germline CYSLTR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Conflicting · 1 Likely benign · 39 Uncertain significance
Full CYSLTR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYSLTR1 p.Arg22His Uncertain significance Single submitter
- CYSLTR1 p.Arg253His Uncertain significance Single submitter
- CYSLTR1 p.Arg79His Uncertain significance Single submitter
- CYSLTR1 p.Arg79Leu Uncertain significance Single submitter
- CYSLTR1 p.Cys335Tyr Uncertain significance Single submitter
- CYSLTR1 p.Cys96Trp Uncertain significance Single submitter
- CYSLTR1 p.His261Tyr Uncertain significance Single submitter
- CYSLTR1 p.His312Asp Uncertain significance Single submitter
- CYSLTR1 p.Ile152Phe Uncertain significance Single submitter
- CYSLTR1 p.Ile334Leu Uncertain significance Single submitter
- CYSLTR1 p.Ile49Val Uncertain significance Single submitter
- CYSLTR1 p.Leu70Pro Uncertain significance Single submitter
- CYSLTR1 p.Leu7Val Uncertain significance Single submitter
- CYSLTR1 p.Leu90Val Uncertain significance Single submitter
- CYSLTR1 p.Lys330Arg Uncertain significance Single submitter
- CYSLTR1 p.Lys55Gln Uncertain significance Single submitter
- CYSLTR1 p.Met117Val Uncertain significance Single submitter
- CYSLTR1 p.Met247Leu Uncertain significance Single submitter
- CYSLTR1 p.Pro163Ala Uncertain significance Single submitter
- CYSLTR1 p.Pro266Ser Uncertain significance Single submitter
- CYSLTR1 p.Pro321Ala Uncertain significance Single submitter
- CYSLTR1 p.Ser245Cys Uncertain significance Single submitter
- CYSLTR1 p.Val203Ile Uncertain significance Single submitter
- CYSLTR1 p.Val317Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CYSLTR1 p.Arg97His Uncertain significance Single submitter
- CYSLTR1 p.Asn287Ser Uncertain significance Single submitter
- CYSLTR1 p.Asn6Asp Uncertain significance Single submitter
- CYSLTR1 p.Asn6Tyr Uncertain significance Single submitter
- CYSLTR1 p.Ile152Asn Uncertain significance Single submitter
- CYSLTR1 p.Lys165Asn Uncertain significance Single submitter
- CYSLTR1 p.Met62Val Uncertain significance Single submitter
- CYSLTR1 p.Phe91Leu Uncertain significance Single submitter
- CYSLTR1 p.Ser276Phe Uncertain significance Single submitter
- CYSLTR1 p.Thr17Pro Uncertain significance Single submitter
- CYSLTR1 p.Thr8Ala Uncertain significance Single submitter
- CYSLTR1 p.Val126Ile Uncertain significance Single submitter
- CYSLTR1 p.Val237Ile Uncertain significance Single submitter
- CYSLTR1 p.Val238Met Uncertain significance Single submitter
All CYSLTR1 variants
Conflicting classifications of pathogenicity 1
- p.Arg121Trp Single submitter ⚠
Likely benign 1
- p.Leu294= Single submitter
Uncertain significance 39
- p.Arg22His Single submitter ⚠
- p.Arg253His Single submitter ⚠
- p.Arg79His Single submitter ⚠
- p.Arg79Leu Single submitter ⚠
- p.Arg97His Single submitter ⚠
- p.Asn287Ser Single submitter ⚠
- p.Asn6Asp Single submitter ⚠
- p.Asn6Tyr Single submitter ⚠
- p.Cys335Tyr Single submitter ⚠
- p.Cys96Trp Single submitter ⚠
- p.His261Tyr Single submitter ⚠
- p.His312Asp Single submitter ⚠
- p.Ile152Asn Single submitter ⚠
- p.Ile152Phe Single submitter ⚠
- p.Ile334Leu Single submitter ⚠
- p.Ile49Val Single submitter ⚠
- p.Leu70Pro Single submitter ⚠
- p.Leu7Val Single submitter ⚠
- p.Leu90Val Single submitter ⚠
- p.Lys165Asn Single submitter ⚠
- p.Lys330Arg Single submitter ⚠
- p.Lys55Gln Single submitter ⚠
- p.Met117Val Single submitter ⚠
- p.Met247Leu Single submitter ⚠
- p.Met62Val Single submitter ⚠
- p.Phe91Leu Single submitter ⚠
- p.Pro163Ala Single submitter ⚠
- p.Pro266Ser Single submitter ⚠
- p.Pro321Ala Single submitter ⚠
- p.Ser245Cys Single submitter ⚠
- p.Ser276Phe Single submitter ⚠
- p.Thr17Pro Single submitter ⚠
- p.Thr8Ala Single submitter ⚠
- p.Val126Ile Single submitter ⚠
- p.Val203Ile Single submitter ⚠
- p.Val237Ile Single submitter ⚠
- p.Val238Met Single submitter ⚠
- p.Val317Leu Single submitter ⚠
- p.Asn23fs No assertion criteria prostate cancer