CYSLTR2 — 64 ClinVar variants
All ClinVar germline CYSLTR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
7 Benign · 8 Likely benign · 49 Uncertain significance
Full CYSLTR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYSLTR2 p.Met201Val Uncertain significance Multiple submitters
- CYSLTR2 p.Ala205Thr Uncertain significance Single submitter
- CYSLTR2 p.Arg226Gln Uncertain significance Single submitter
- CYSLTR2 p.Arg239Gln Uncertain significance Single submitter
- CYSLTR2 p.Asn297Ser Uncertain significance Single submitter
- CYSLTR2 p.Asn311Lys Uncertain significance Single submitter
- CYSLTR2 p.Asp108Tyr Uncertain significance Single submitter
- CYSLTR2 p.Asp84Asn Uncertain significance Single submitter
- CYSLTR2 p.Cys111Ser Uncertain significance Single submitter
- CYSLTR2 p.Glu232Gln Uncertain significance Single submitter
- CYSLTR2 p.Glu34Ala Uncertain significance Single submitter
- CYSLTR2 p.Gly182Ser Uncertain significance Single submitter
- CYSLTR2 p.Ile113Val Uncertain significance Single submitter
- CYSLTR2 p.Ile204Met Uncertain significance Single submitter
- CYSLTR2 p.Ile43Asn Uncertain significance Single submitter
- CYSLTR2 p.Leu132Arg Uncertain significance Single submitter
- CYSLTR2 p.Leu173Phe Uncertain significance Single submitter
- CYSLTR2 p.Leu192Ile Uncertain significance Single submitter
- CYSLTR2 p.Leu287Phe Uncertain significance Single submitter
- CYSLTR2 p.Leu80Pro Uncertain significance Single submitter
- CYSLTR2 p.Lys244Arg Uncertain significance Single submitter
- CYSLTR2 p.Pro19Leu Uncertain significance Single submitter
- CYSLTR2 p.Pro234Ser Uncertain significance Single submitter
- CYSLTR2 p.Pro302Ser Uncertain significance Single submitter
- CYSLTR2 p.Pro335Ser Uncertain significance Single submitter
- CYSLTR2 p.Ser102Phe Uncertain significance Single submitter
- CYSLTR2 p.Ser117Pro Uncertain significance Single submitter
- CYSLTR2 p.Ser169Thr Uncertain significance Single submitter
- CYSLTR2 p.Ser176Thr Uncertain significance Single submitter
- CYSLTR2 p.Ser70Phe Uncertain significance Single submitter
- CYSLTR2 p.Thr200Ala Uncertain significance Single submitter
- CYSLTR2 p.Thr252Ser Uncertain significance Single submitter
- CYSLTR2 p.Thr268Ala Uncertain significance Single submitter
- CYSLTR2 p.Tyr123His Uncertain significance Single submitter
- CYSLTR2 p.Tyr67Asp Uncertain significance Single submitter
- CYSLTR2 p.Tyr67His Uncertain significance Single submitter
- CYSLTR2 p.Val131Met Uncertain significance Single submitter
- CYSLTR2 p.Val227Phe Uncertain significance Single submitter
- CYSLTR2 p.Val276Met Uncertain significance Single submitter
- CYSLTR2 p.Val44Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CYSLTR2 p.Ala155Thr Uncertain significance Single submitter
- CYSLTR2 p.Arg243Gly Uncertain significance Single submitter
- CYSLTR2 p.His242Asp Uncertain significance Single submitter
- CYSLTR2 p.Leu118Ser Uncertain significance Single submitter
- CYSLTR2 p.Leu211Gln Uncertain significance Single submitter
- CYSLTR2 p.Met122Ile Uncertain significance Single submitter
- CYSLTR2 p.Pro66Ser Uncertain significance Single submitter
All CYSLTR2 variants
Benign 7
- p.Arg315Lys Multiple submitters
- p.Glu39Gln Multiple submitters
- p.His242Gln Multiple submitters
- p.His270= Multiple submitters
- p.Phe300= Multiple submitters
- p.Ser236Leu Multiple submitters
- p.Thr90= Multiple submitters
Likely benign 8
- p.Asn103Ser Multiple submitters
- p.Leu278Ile Multiple submitters
- p.Phe50Val Multiple submitters
- p.Gln9His Single submitter
- p.Ile166Thr Single submitter
- p.Ile249Val Single submitter
- p.Leu283= Single submitter
- p.Val14Ile Single submitter
Uncertain significance 49
- p.Met201Val Multiple submitters ⚠
- p.Ala155Thr Single submitter ⚠
- p.Ala205Thr Single submitter ⚠
- p.Arg226Gln Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg243Gly Single submitter ⚠
- p.Asn297Ser Single submitter ⚠
- p.Asn311Lys Single submitter ⚠
- p.Asp108Tyr Single submitter ⚠
- p.Asp84Asn Single submitter ⚠
- p.Cys111Ser Single submitter ⚠
- p.Cys259Gly Single submitter
- p.Glu232Gln Single submitter ⚠
- p.Glu34Ala Single submitter ⚠
- p.Gly182Ser Single submitter ⚠
- p.His242Asp Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Ile204Met Single submitter ⚠
- p.Ile43Asn Single submitter ⚠
- p.Leu118Ser Single submitter ⚠
- p.Leu132Arg Single submitter ⚠
- p.Leu173Phe Single submitter ⚠
- p.Leu192Ile Single submitter ⚠
- p.Leu211Gln Single submitter ⚠
- p.Leu287Phe Single submitter ⚠
- p.Leu80Pro Single submitter ⚠
- p.Lys244Arg Single submitter ⚠
- p.Met122Ile Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Pro234Ser Single submitter ⚠
- p.Pro302Ser Single submitter ⚠
- p.Pro335Ser Single submitter ⚠
- p.Pro66Ser Single submitter ⚠
- p.Ser102Phe Single submitter ⚠
- p.Ser117Pro Single submitter ⚠
- p.Ser169Thr Single submitter ⚠
- p.Ser176Thr Single submitter ⚠
- p.Ser70Phe Single submitter ⚠
- p.Thr200Ala Single submitter ⚠
- p.Thr252Ser Single submitter ⚠
- p.Thr268Ala Single submitter ⚠
- p.Thr71Ile Single submitter
- p.Tyr123His Single submitter ⚠
- p.Tyr67Asp Single submitter ⚠
- p.Tyr67His Single submitter ⚠
- p.Val131Met Single submitter ⚠
- p.Val227Phe Single submitter ⚠
- p.Val276Met Single submitter ⚠
- p.Val44Ala Single submitter ⚠