CYSRT1 — 34 ClinVar variants
All ClinVar germline CYSRT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
34 Uncertain significance
Full CYSRT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYSRT1 p.Ala76Ser Uncertain significance Single submitter
- CYSRT1 p.Ala98Asp Uncertain significance Single submitter
- CYSRT1 p.Arg110His Uncertain significance Single submitter
- CYSRT1 p.Arg134Cys Uncertain significance Single submitter
- CYSRT1 p.Arg134His Uncertain significance Single submitter
- CYSRT1 p.Arg96His Uncertain significance Single submitter
- CYSRT1 p.Asp2Glu Uncertain significance Single submitter
- CYSRT1 p.Gln29His Uncertain significance Single submitter
- CYSRT1 p.Gln29Leu Uncertain significance Single submitter
- CYSRT1 p.Gln4Glu Uncertain significance Single submitter
- CYSRT1 p.Glu41Asp Uncertain significance Single submitter
- CYSRT1 p.Glu53Asp Uncertain significance Single submitter
- CYSRT1 p.Glu5Lys Uncertain significance Single submitter
- CYSRT1 p.Glu62Lys Uncertain significance Single submitter
- CYSRT1 p.Gly27Arg Uncertain significance Single submitter
- CYSRT1 p.Gly68Asp Uncertain significance Single submitter
- CYSRT1 p.His21Tyr Uncertain significance Single submitter
- CYSRT1 p.Ile17Thr Uncertain significance Single submitter
- CYSRT1 p.Leu100Met Uncertain significance Single submitter
- CYSRT1 p.Pro106Leu Uncertain significance Single submitter
- CYSRT1 p.Pro122His Uncertain significance Single submitter
- CYSRT1 p.Pro130Ser Uncertain significance Single submitter
- CYSRT1 p.Pro77Ala Uncertain significance Single submitter
- CYSRT1 p.Ser40Leu Uncertain significance Single submitter
- CYSRT1 p.Thr55Ala Uncertain significance Single submitter
- CYSRT1 p.Thr61Asn Uncertain significance Single submitter
- CYSRT1 p.Thr61Ser Uncertain significance Single submitter
- CYSRT1 p.Val47Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CYSRT1 p.Cys118Arg Uncertain significance Single submitter
- CYSRT1 p.Cys138Tyr Uncertain significance Single submitter
- CYSRT1 p.Cys139Trp Uncertain significance Single submitter
- CYSRT1 p.Gly111Arg Uncertain significance Single submitter
- CYSRT1 p.Pro90Arg Uncertain significance Single submitter
- CYSRT1 p.Tyr12His Uncertain significance Single submitter
All CYSRT1 variants
Uncertain significance 34
- p.Ala76Ser Single submitter ⚠
- p.Ala98Asp Single submitter ⚠
- p.Arg110His Single submitter ⚠
- p.Arg134Cys Single submitter ⚠
- p.Arg134His Single submitter ⚠
- p.Arg96His Single submitter ⚠
- p.Asp2Glu Single submitter ⚠
- p.Cys118Arg Single submitter ⚠
- p.Cys138Tyr Single submitter ⚠
- p.Cys139Trp Single submitter ⚠
- p.Gln29His Single submitter ⚠
- p.Gln29Leu Single submitter ⚠
- p.Gln4Glu Single submitter ⚠
- p.Glu41Asp Single submitter ⚠
- p.Glu53Asp Single submitter ⚠
- p.Glu5Lys Single submitter ⚠
- p.Glu62Lys Single submitter ⚠
- p.Gly111Arg Single submitter ⚠
- p.Gly27Arg Single submitter ⚠
- p.Gly68Asp Single submitter ⚠
- p.His21Tyr Single submitter ⚠
- p.Ile17Thr Single submitter ⚠
- p.Leu100Met Single submitter ⚠
- p.Pro106Leu Single submitter ⚠
- p.Pro122His Single submitter ⚠
- p.Pro130Ser Single submitter ⚠
- p.Pro77Ala Single submitter ⚠
- p.Pro90Arg Single submitter ⚠
- p.Ser40Leu Single submitter ⚠
- p.Thr55Ala Single submitter ⚠
- p.Thr61Asn Single submitter ⚠
- p.Thr61Ser Single submitter ⚠
- p.Tyr12His Single submitter ⚠
- p.Val47Ala Single submitter ⚠