CYTH2 — 34 ClinVar variants
All ClinVar germline CYTH2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
34 Uncertain significance
Full CYTH2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYTH2 p.Ala168Thr Uncertain significance Single submitter
- CYTH2 p.Arg262Gln Uncertain significance Single submitter
- CYTH2 p.Arg98His Uncertain significance Single submitter
- CYTH2 p.Asp3Glu Uncertain significance Single submitter
- CYTH2 p.Gln360Arg Uncertain significance Single submitter
- CYTH2 p.Glu38Asp Uncertain significance Single submitter
- CYTH2 p.Gly331Arg Uncertain significance Single submitter
- CYTH2 p.Gly55Ser Uncertain significance Single submitter
- CYTH2 p.Ile193Val Uncertain significance Single submitter
- CYTH2 p.Lys393Arg Uncertain significance Single submitter
- CYTH2 p.Lys394Arg Uncertain significance Single submitter
- CYTH2 p.Met163Val Uncertain significance Single submitter
- CYTH2 p.Thr184Met Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CYTH2 p.Ala385Val Uncertain significance Single submitter
- CYTH2 p.Arg212His Uncertain significance Single submitter
- CYTH2 p.Arg232Thr Uncertain significance Single submitter
- CYTH2 p.Arg344Gln Uncertain significance Single submitter
- CYTH2 p.Arg35Cys Uncertain significance Single submitter
- CYTH2 p.Arg61Gln Uncertain significance Single submitter
- CYTH2 p.Asn86Ser Uncertain significance Single submitter
- CYTH2 p.Glu211Ala Uncertain significance Single submitter
- CYTH2 p.Glu365Lys Uncertain significance Single submitter
- CYTH2 p.Glu39Gln Uncertain significance Single submitter
- CYTH2 p.Glu51Lys Uncertain significance Single submitter
- CYTH2 p.Glu54Lys Uncertain significance Single submitter
- CYTH2 p.Glu85Gly Uncertain significance Single submitter
- CYTH2 p.Glu94Lys Uncertain significance Single submitter
- CYTH2 p.Gly224Arg Uncertain significance Single submitter
- CYTH2 p.Met67Thr Uncertain significance Single submitter
- CYTH2 p.Pro13Leu Uncertain significance Single submitter
- CYTH2 p.Pro8Thr Uncertain significance Single submitter
- CYTH2 p.Tyr101Phe Uncertain significance Single submitter
- CYTH2 p.Val273Leu Uncertain significance Single submitter
- CYTH2 p.Val374Met Uncertain significance Single submitter
All CYTH2 variants
Uncertain significance 34
- p.Ala168Thr Single submitter ⚠
- p.Ala385Val Single submitter ⚠
- p.Arg212His Single submitter ⚠
- p.Arg232Thr Single submitter ⚠
- p.Arg262Gln Single submitter ⚠
- p.Arg344Gln Single submitter ⚠
- p.Arg35Cys Single submitter ⚠
- p.Arg61Gln Single submitter ⚠
- p.Arg98His Single submitter ⚠
- p.Asn86Ser Single submitter ⚠
- p.Asp3Glu Single submitter ⚠
- p.Gln360Arg Single submitter ⚠
- p.Glu211Ala Single submitter ⚠
- p.Glu365Lys Single submitter ⚠
- p.Glu38Asp Single submitter ⚠
- p.Glu39Gln Single submitter ⚠
- p.Glu51Lys Single submitter ⚠
- p.Glu54Lys Single submitter ⚠
- p.Glu85Gly Single submitter ⚠
- p.Glu94Lys Single submitter ⚠
- p.Gly224Arg Single submitter ⚠
- p.Gly331Arg Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.Ile193Val Single submitter ⚠
- p.Lys393Arg Single submitter ⚠
- p.Lys394Arg Single submitter ⚠
- p.Met163Val Single submitter ⚠
- p.Met67Thr Single submitter ⚠
- p.Pro13Leu Single submitter ⚠
- p.Pro8Thr Single submitter ⚠
- p.Thr184Met Single submitter ⚠
- p.Tyr101Phe Single submitter ⚠
- p.Val273Leu Single submitter ⚠
- p.Val374Met Single submitter ⚠