CYTH3 — 33 ClinVar variants
All ClinVar germline CYTH3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
33 Uncertain significance
Full CYTH3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYTH3 p.Ala389Val Uncertain significance Single submitter
- CYTH3 p.Arg175Gly Uncertain significance Single submitter
- CYTH3 p.Arg283Cys Uncertain significance Single submitter
- CYTH3 p.Arg284Trp Uncertain significance Single submitter
- CYTH3 p.Arg322Gln Uncertain significance Single submitter
- CYTH3 p.Arg66Gly Uncertain significance Single submitter
- CYTH3 p.Asn144Ser Uncertain significance Single submitter
- CYTH3 p.Asp142Tyr Uncertain significance Single submitter
- CYTH3 p.Asp347Ala Uncertain significance Single submitter
- CYTH3 p.Asp92Glu Uncertain significance Single submitter
- CYTH3 p.Gly11Ser Uncertain significance Single submitter
- CYTH3 p.His138Tyr Uncertain significance Single submitter
- CYTH3 p.Pro365Gln Uncertain significance Single submitter
- CYTH3 p.Thr114Asn Uncertain significance Single submitter
- CYTH3 p.Thr50Ala Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CYTH3 p.Arg223His Uncertain significance Single submitter
- CYTH3 p.Arg29Gln Uncertain significance Single submitter
- CYTH3 p.Arg359Gln Uncertain significance Single submitter
- CYTH3 p.Arg393Gln Uncertain significance Single submitter
- CYTH3 p.Asn331Ser Uncertain significance Single submitter
- CYTH3 p.Asp211Glu Uncertain significance Single submitter
- CYTH3 p.Asp347Asn Uncertain significance Single submitter
- CYTH3 p.Gln147His Uncertain significance Single submitter
- CYTH3 p.Ile35Val Uncertain significance Single submitter
- CYTH3 p.Ile375Met Uncertain significance Single submitter
- CYTH3 p.Leu25Val Uncertain significance Single submitter
- CYTH3 p.Lys32Asn Uncertain significance Single submitter
- CYTH3 p.Lys42Arg Uncertain significance Single submitter
- CYTH3 p.Lys42Gln Uncertain significance Single submitter
- CYTH3 p.Lys68Arg Uncertain significance Single submitter
- CYTH3 p.Met72Ile Uncertain significance Single submitter
- CYTH3 p.Val115Ile Uncertain significance Single submitter
- CYTH3 p.Val58Leu Uncertain significance Single submitter
All CYTH3 variants
Uncertain significance 33
- p.Ala389Val Single submitter ⚠
- p.Arg175Gly Single submitter ⚠
- p.Arg223His Single submitter ⚠
- p.Arg283Cys Single submitter ⚠
- p.Arg284Trp Single submitter ⚠
- p.Arg29Gln Single submitter ⚠
- p.Arg322Gln Single submitter ⚠
- p.Arg359Gln Single submitter ⚠
- p.Arg393Gln Single submitter ⚠
- p.Arg66Gly Single submitter ⚠
- p.Asn144Ser Single submitter ⚠
- p.Asn331Ser Single submitter ⚠
- p.Asp142Tyr Single submitter ⚠
- p.Asp211Glu Single submitter ⚠
- p.Asp347Ala Single submitter ⚠
- p.Asp347Asn Single submitter ⚠
- p.Asp92Glu Single submitter ⚠
- p.Gln147His Single submitter ⚠
- p.Gly11Ser Single submitter ⚠
- p.His138Tyr Single submitter ⚠
- p.Ile35Val Single submitter ⚠
- p.Ile375Met Single submitter ⚠
- p.Leu25Val Single submitter ⚠
- p.Lys32Asn Single submitter ⚠
- p.Lys42Arg Single submitter ⚠
- p.Lys42Gln Single submitter ⚠
- p.Lys68Arg Single submitter ⚠
- p.Met72Ile Single submitter ⚠
- p.Pro365Gln Single submitter ⚠
- p.Thr114Asn Single submitter ⚠
- p.Thr50Ala Single submitter ⚠
- p.Val115Ile Single submitter ⚠
- p.Val58Leu Single submitter ⚠