CYTH4 — 55 ClinVar variants
All ClinVar germline CYTH4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
3 Benign · 3 Likely benign · 49 Uncertain significance
Full CYTH4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYTH4 p.Ala136Thr Uncertain significance Single submitter
- CYTH4 p.Ala9Glu Uncertain significance Single submitter
- CYTH4 p.Asn122Lys Uncertain significance Single submitter
- CYTH4 p.Cys321Tyr Uncertain significance Single submitter
- CYTH4 p.Glu241Lys Uncertain significance Single submitter
- CYTH4 p.Glu351Lys Uncertain significance Single submitter
- CYTH4 p.Gly14Arg Uncertain significance Single submitter
- CYTH4 p.Gly264Val Uncertain significance Single submitter
- CYTH4 p.Ile303Thr Uncertain significance Single submitter
- CYTH4 p.Leu188Phe Uncertain significance Single submitter
- CYTH4 p.Met58Ile Uncertain significance Single submitter
- CYTH4 p.Phe147Leu Uncertain significance Single submitter
- CYTH4 p.Phe213Leu Uncertain significance Single submitter
- CYTH4 p.Pro304Ser Uncertain significance Single submitter
- CYTH4 p.Pro6Thr Uncertain significance Single submitter
- CYTH4 p.Pro8Ala Uncertain significance Single submitter
- CYTH4 p.Ser237Ile Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- CYTH4 p.Asn107His Benign Multiple submitters
- CYTH4 p.Met74Val Benign Multiple submitters
- CYTH4 p.Ala166Thr Likely benign Single submitter
- CYTH4 p.Ala166Val Uncertain significance Single submitter
- CYTH4 p.Arg205Gln Uncertain significance Single submitter
- CYTH4 p.Arg212Cys Uncertain significance Single submitter
- CYTH4 p.Arg218Cys Uncertain significance Single submitter
- CYTH4 p.Arg218His Uncertain significance Single submitter
- CYTH4 p.Arg232Gln Uncertain significance Single submitter
- CYTH4 p.Arg232Trp Uncertain significance Single submitter
- CYTH4 p.Arg262Gln Uncertain significance Single submitter
- CYTH4 p.Arg26Gln Uncertain significance Single submitter
- CYTH4 p.Arg330Gln Uncertain significance Single submitter
- CYTH4 p.Arg376Cys Uncertain significance Single submitter
- CYTH4 p.Arg376His Uncertain significance Single submitter
- CYTH4 p.Arg386Gln Uncertain significance Single submitter
- CYTH4 p.Arg386Trp Uncertain significance Single submitter
- CYTH4 p.Asn217Ser Uncertain significance Single submitter
- CYTH4 p.Asp381Asn Uncertain significance Single submitter
- CYTH4 p.Asp48Asn Uncertain significance Single submitter
- CYTH4 p.Gln127Arg Uncertain significance Single submitter
- CYTH4 p.Gln146Leu Uncertain significance Single submitter
- CYTH4 p.Gln332Arg Uncertain significance Single submitter
- CYTH4 p.Glu104Lys Uncertain significance Single submitter
- CYTH4 p.Glu228Lys Uncertain significance Single submitter
- CYTH4 p.Gly250Ser Uncertain significance Single submitter
- CYTH4 p.Gly343Ser Uncertain significance Single submitter
- CYTH4 p.Ile334Val Uncertain significance Single submitter
- CYTH4 p.Leu253Phe Uncertain significance Single submitter
- CYTH4 p.Met216Val Uncertain significance Single submitter
- CYTH4 p.Ser13Asn Uncertain significance Single submitter
- CYTH4 p.Thr339Ile Uncertain significance Single submitter
- CYTH4 p.Tyr101Cys Uncertain significance Single submitter
- CYTH4 p.Val125Ile Uncertain significance Single submitter
- CYTH4 p.Val178Ile Uncertain significance Single submitter
- CYTH4 p.Val93Ile Likely benign Single submitter
All CYTH4 variants
Benign 3
- p.Asn107His Multiple submitters ⚠
- p.Leu88= Multiple submitters
- p.Met74Val Multiple submitters ⚠
Likely benign 3
- p.Ala166Thr Single submitter ⚠
- p.Asn222Asp Single submitter
- p.Val93Ile Single submitter ⚠
Uncertain significance 49
- p.Ala136Thr Single submitter ⚠
- p.Ala166Val Single submitter ⚠
- p.Ala9Glu Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg218Cys Single submitter ⚠
- p.Arg218His Single submitter ⚠
- p.Arg232Gln Single submitter ⚠
- p.Arg232Trp Single submitter ⚠
- p.Arg262Gln Single submitter ⚠
- p.Arg26Gln Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg376Cys Single submitter ⚠
- p.Arg376His Single submitter ⚠
- p.Arg386Gln Single submitter ⚠
- p.Arg386Trp Single submitter ⚠
- p.Asn122Lys Single submitter ⚠
- p.Asn217Ser Single submitter ⚠
- p.Asp381Asn Single submitter ⚠
- p.Asp48Asn Single submitter ⚠
- p.Cys321Tyr Single submitter ⚠
- p.Gln127Arg Single submitter ⚠
- p.Gln146Leu Single submitter ⚠
- p.Gln332Arg Single submitter ⚠
- p.Glu104Lys Single submitter ⚠
- p.Glu228Lys Single submitter ⚠
- p.Glu241Lys Single submitter ⚠
- p.Glu351Lys Single submitter ⚠
- p.Gly14Arg Single submitter ⚠
- p.Gly250Ser Single submitter ⚠
- p.Gly264Val Single submitter ⚠
- p.Gly343Ser Single submitter ⚠
- p.Ile303Thr Single submitter ⚠
- p.Ile334Val Single submitter ⚠
- p.Leu188Phe Single submitter ⚠
- p.Leu253Phe Single submitter ⚠
- p.Met216Val Single submitter ⚠
- p.Met58Ile Single submitter ⚠
- p.Phe147Leu Single submitter ⚠
- p.Phe213Leu Single submitter ⚠
- p.Pro304Ser Single submitter ⚠
- p.Pro6Thr Single submitter ⚠
- p.Pro8Ala Single submitter ⚠
- p.Ser13Asn Single submitter ⚠
- p.Ser237Ile Single submitter ⚠
- p.Thr339Ile Single submitter ⚠
- p.Tyr101Cys Single submitter ⚠
- p.Val125Ile Single submitter ⚠
- p.Val178Ile Single submitter ⚠