CYTL1 — 29 ClinVar variants
All ClinVar germline CYTL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Likely benign · 28 Uncertain significance
Full CYTL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CYTL1 p.Arg134Gly Uncertain significance Single submitter
- CYTL1 p.Arg136His Uncertain significance Single submitter
- CYTL1 p.Arg21Leu Uncertain significance Single submitter
- CYTL1 p.Arg30Cys Uncertain significance Single submitter
- CYTL1 p.Cys107Phe Uncertain significance Single submitter
- CYTL1 p.Cys118Arg Uncertain significance Single submitter
- CYTL1 p.Glu49Gln Uncertain significance Single submitter
- CYTL1 p.Leu111Val Uncertain significance Single submitter
- CYTL1 p.Leu131Val Uncertain significance Single submitter
- CYTL1 p.Phe77Ser Uncertain significance Single submitter
- CYTL1 p.Pro18Arg Uncertain significance Single submitter
- CYTL1 p.Ser80Leu Uncertain significance Single submitter
- CYTL1 p.Thr23Ser Uncertain significance Single submitter
- CYTL1 p.Tyr28Cys Uncertain significance Single submitter
- CYTL1 p.Tyr28His Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CYTL1 p.Arg56Ile Uncertain significance Single submitter
- CYTL1 p.Arg75Gln Uncertain significance Single submitter
- CYTL1 p.Arg97Gln Uncertain significance Single submitter
- CYTL1 p.Leu13Phe Uncertain significance Single submitter
- CYTL1 p.Lys73Asn Uncertain significance Single submitter
- CYTL1 p.Lys93Asn Uncertain significance Single submitter
- CYTL1 p.Pro132Arg Uncertain significance Single submitter
- CYTL1 p.Pro50His Uncertain significance Single submitter
- CYTL1 p.Pro82Leu Uncertain significance Single submitter
- CYTL1 p.Ser48Pro Uncertain significance Single submitter
- CYTL1 p.Thr128Ile Uncertain significance Single submitter
- CYTL1 p.Thr129Met Uncertain significance Single submitter
- CYTL1 p.Val89Ile Uncertain significance Single submitter
All CYTL1 variants
Likely benign 1
- p.Arg134His Single submitter
Uncertain significance 28
- p.Arg134Gly Single submitter ⚠
- p.Arg136His Single submitter ⚠
- p.Arg21Leu Single submitter ⚠
- p.Arg30Cys Single submitter ⚠
- p.Arg56Ile Single submitter ⚠
- p.Arg75Gln Single submitter ⚠
- p.Arg97Gln Single submitter ⚠
- p.Cys107Phe Single submitter ⚠
- p.Cys118Arg Single submitter ⚠
- p.Glu49Gln Single submitter ⚠
- p.Leu111Val Single submitter ⚠
- p.Leu131Val Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Lys73Asn Single submitter ⚠
- p.Lys93Asn Single submitter ⚠
- p.Phe77Ser Single submitter ⚠
- p.Pro132Arg Single submitter ⚠
- p.Pro18Arg Single submitter ⚠
- p.Pro50His Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Ser48Pro Single submitter ⚠
- p.Ser80Leu Single submitter ⚠
- p.Thr128Ile Single submitter ⚠
- p.Thr129Met Single submitter ⚠
- p.Thr23Ser Single submitter ⚠
- p.Tyr28Cys Single submitter ⚠
- p.Tyr28His Single submitter ⚠
- p.Val89Ile Single submitter ⚠