DAAM1 — 130 ClinVar variants
All ClinVar germline DAAM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 111 flagged for review →
1 Conflicting · 11 Benign · 9 Likely benign · 109 Uncertain significance
Full DAAM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 111
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAAM1 c.1969-1685T>C Uncertain significance Single submitter
- DAAM1 c.1969-1686T>G Uncertain significance Single submitter
- DAAM1 p.Ala37Val Uncertain significance Single submitter
- DAAM1 p.Ala44Pro Uncertain significance Single submitter
- DAAM1 p.Ala522Ser Uncertain significance Single submitter
- DAAM1 p.Ala525Asp Uncertain significance Single submitter
- DAAM1 p.Ala597Thr Uncertain significance Single submitter
- DAAM1 p.Ala799Thr Uncertain significance Single submitter
- DAAM1 p.Ala875Val Uncertain significance Single submitter
- DAAM1 p.Arg1004Leu Uncertain significance Single submitter
- DAAM1 p.Arg1031Cys Uncertain significance Single submitter
- DAAM1 p.Arg1049Cys Uncertain significance Single submitter
- DAAM1 p.Arg176Gln Uncertain significance Single submitter
- DAAM1 p.Arg195Gln Uncertain significance Single submitter
- DAAM1 p.Arg339Gln Uncertain significance Single submitter
- DAAM1 p.Arg407Ile Uncertain significance Single submitter
- DAAM1 p.Arg437Gln Uncertain significance Single submitter
- DAAM1 p.Arg743Gln Uncertain significance Single submitter
- DAAM1 p.Arg756Gly Uncertain significance Single submitter
- DAAM1 p.Arg796Ser Uncertain significance Single submitter
- DAAM1 p.Asn111Ser Uncertain significance Single submitter
- DAAM1 p.Asn821Ser Uncertain significance Single submitter
- DAAM1 p.Asp421Glu Uncertain significance Single submitter
- DAAM1 p.Asp664Gly Uncertain significance Single submitter
- DAAM1 p.Cys160Arg Uncertain significance Single submitter
- DAAM1 p.Gln1003Glu Uncertain significance Single submitter
- DAAM1 p.Gln485Glu Uncertain significance Single submitter
- DAAM1 p.Gln909Arg Uncertain significance Single submitter
- DAAM1 p.Glu171Lys Uncertain significance Single submitter
- DAAM1 p.Glu472Lys Uncertain significance Single submitter
- DAAM1 p.Glu881Val Uncertain significance Single submitter
- DAAM1 p.Gly157Asp Uncertain significance Single submitter
- DAAM1 p.Gly396Ala Uncertain significance Single submitter
-
DAAM1 p.Gly964Asp
Uncertain significance
Single submitter
DAAM1-related disorder
- DAAM1 p.Ile14Val Uncertain significance Single submitter
- DAAM1 p.Ile285Phe Uncertain significance Single submitter
- DAAM1 p.Ile409Val Uncertain significance Single submitter
- DAAM1 p.Ile731Val Uncertain significance Single submitter
- DAAM1 p.Ile840Val Uncertain significance Single submitter
- DAAM1 p.Ile853Val Uncertain significance Single submitter
- DAAM1 p.Leu162Phe Uncertain significance Single submitter
- DAAM1 p.Leu245Pro Uncertain significance Single submitter
- DAAM1 p.Leu557Pro Uncertain significance Single submitter
- DAAM1 p.Lys1048Arg Uncertain significance Single submitter
- DAAM1 p.Lys454Glu Uncertain significance Single submitter
- DAAM1 p.Lys468Arg Uncertain significance Single submitter
- DAAM1 p.Lys617Thr Uncertain significance Single submitter
- DAAM1 p.Met41Val Uncertain significance Single submitter
- DAAM1 p.Met47Leu Uncertain significance Single submitter
- DAAM1 p.Met879Val Uncertain significance Single submitter
- DAAM1 p.Met996Val Uncertain significance Single submitter
- DAAM1 p.Phe334Tyr Uncertain significance Single submitter
- DAAM1 p.Phe649Tyr Uncertain significance Single submitter
- DAAM1 p.Pro103Arg Uncertain significance Single submitter
- DAAM1 p.Pro426Ser Uncertain significance Single submitter
- DAAM1 p.Pro908Gln Uncertain significance Single submitter
- DAAM1 p.Pro910Ala Uncertain significance Single submitter
- DAAM1 p.Ser131Cys Uncertain significance Single submitter
- DAAM1 p.Ser136Arg Uncertain significance Single submitter
- DAAM1 p.Ser326Pro Uncertain significance Single submitter
- DAAM1 p.Ser532Leu Uncertain significance Single submitter
- DAAM1 p.Ser58Gly Uncertain significance Single submitter
- DAAM1 p.Ser891Thr Uncertain significance Single submitter
- DAAM1 p.Val198Ile Uncertain significance Single submitter
- DAAM1 p.Val436Ile Uncertain significance Single submitter
- DAAM1 p.Val877Ile Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- DAAM1 p.Arg1011Gly Uncertain significance Multiple submitters
- DAAM1 p.Phe752Leu Uncertain significance Multiple submitters
- DAAM1 p.Ala452Thr Uncertain significance Single submitter
- DAAM1 p.Ala452Val Uncertain significance Single submitter
- DAAM1 p.Arg1004His Uncertain significance Single submitter
- DAAM1 p.Arg1008His Uncertain significance Single submitter
- DAAM1 p.Arg1049His Uncertain significance Single submitter
- DAAM1 p.Arg270Trp Uncertain significance Single submitter
- DAAM1 p.Arg437Leu Uncertain significance Single submitter
- DAAM1 p.Arg788His Uncertain significance Single submitter
- DAAM1 p.Arg995His Uncertain significance Single submitter
- DAAM1 p.Asn416His Uncertain significance Single submitter
- DAAM1 p.Asn608Asp Uncertain significance Single submitter
- DAAM1 p.Asp154Asn Uncertain significance Single submitter
- DAAM1 p.Gln242Arg Uncertain significance Single submitter
- DAAM1 p.Gln400His Uncertain significance Single submitter
- DAAM1 p.Gln485His Uncertain significance Single submitter
- DAAM1 p.Glu1019Gln Uncertain significance Single submitter
- DAAM1 p.Glu1022Lys Uncertain significance Single submitter
- DAAM1 p.Glu855Gly Uncertain significance Single submitter
- DAAM1 p.Glu94Lys Uncertain significance Single submitter
- DAAM1 p.Gly538Arg Uncertain significance Single submitter
- DAAM1 p.Gly546Val Uncertain significance Single submitter
- DAAM1 p.Gly595Arg Uncertain significance Single submitter
- DAAM1 p.Gly955Ser Uncertain significance Single submitter
- DAAM1 p.Ile107Val Uncertain significance Single submitter
- DAAM1 p.Ile177Thr Uncertain significance Single submitter
- DAAM1 p.Leu562Phe Uncertain significance Single submitter
- DAAM1 p.Leu569Ile Uncertain significance Single submitter
- DAAM1 p.Phe914Leu Uncertain significance Single submitter
- DAAM1 p.Pro558Leu Likely benign Single submitter
- DAAM1 p.Pro566Gln Uncertain significance Single submitter
- DAAM1 p.Pro578Gln Uncertain significance Single submitter
- DAAM1 p.Pro588Leu Uncertain significance Single submitter
- DAAM1 p.Pro619Arg Uncertain significance Single submitter
- DAAM1 p.Pro619Thr Uncertain significance Single submitter
- DAAM1 p.Pro714Ala Uncertain significance Single submitter
- DAAM1 p.Pro959Ala Uncertain significance Single submitter
- DAAM1 p.Ser766Leu Uncertain significance Single submitter
- DAAM1 p.Ser919Asn Uncertain significance Single submitter
- DAAM1 p.Thr259Ala Uncertain significance Single submitter
- DAAM1 p.Tyr170Cys Uncertain significance Single submitter
- DAAM1 p.Val230Met Uncertain significance Single submitter
- DAAM1 p.Val973Ala Uncertain significance Single submitter
All DAAM1 variants
Conflicting classifications of pathogenicity 1
- p.Ile134Val Single submitter Seizure ⚠
Benign 11
- p.Asn865His Multiple submitters
- p.Leu804= Multiple submitters
- p.Pro49= Multiple submitters
- c.1560+9T>G Single submitter
- p.Leu596= Single submitter
- p.Pro378= Single submitter
- c.1373-6G>A No assertion criteria DAAM1-related disorder
- p.Ala509= No assertion criteria DAAM1-related disorder
- p.Gln463= No assertion criteria DAAM1-related disorder
- p.Leu241= No assertion criteria DAAM1-related disorder
- p.Lys186= No assertion criteria DAAM1-related disorder
Likely benign 9
- p.Asp679= Multiple submitters
- c.1969-1681T>C Single submitter
- p.Arg869Gln Single submitter
- p.His323= Single submitter
- p.Leu690= Single submitter
- p.Pro558Leu Single submitter ⚠
- c.2694+8T>C No assertion criteria DAAM1-related disorder
- p.Gly8= No assertion criteria DAAM1-related disorder
- p.Pro556= No assertion criteria DAAM1-related disorder
Uncertain significance 109
- p.Arg1011Gly Multiple submitters ⚠
- p.Phe752Leu Multiple submitters ⚠
- c.1969-1685T>C Single submitter ⚠
- c.1969-1686T>G Single submitter ⚠
- p.Ala37Val Single submitter ⚠
- p.Ala44Pro Single submitter ⚠
- p.Ala452Thr Single submitter ⚠
- p.Ala452Val Single submitter ⚠
- p.Ala522Ser Single submitter ⚠
- p.Ala525Asp Single submitter ⚠
- p.Ala597Thr Single submitter ⚠
- p.Ala799Thr Single submitter ⚠
- p.Ala875Val Single submitter ⚠
- p.Arg1004His Single submitter ⚠
- p.Arg1004Leu Single submitter ⚠
- p.Arg1008His Single submitter ⚠
- p.Arg1031Cys Single submitter ⚠
- p.Arg1049Cys Single submitter ⚠
- p.Arg1049His Single submitter ⚠
- p.Arg176Gln Single submitter ⚠
- p.Arg195Gln Single submitter ⚠
- p.Arg270Trp Single submitter ⚠
- p.Arg339Gln Single submitter ⚠
- p.Arg407Ile Single submitter ⚠
- p.Arg437Gln Single submitter ⚠
- p.Arg437Leu Single submitter ⚠
- p.Arg743Gln Single submitter ⚠
- p.Arg756Gly Single submitter ⚠
- p.Arg788His Single submitter ⚠
- p.Arg796Ser Single submitter ⚠
- p.Arg995His Single submitter ⚠
- p.Asn111Ser Single submitter ⚠
- p.Asn416His Single submitter ⚠
- p.Asn608Asp Single submitter ⚠
- p.Asn821Ser Single submitter ⚠
- p.Asp154Asn Single submitter ⚠
- p.Asp421Glu Single submitter ⚠
- p.Asp664Gly Single submitter ⚠
- p.Cys160Arg Single submitter ⚠
- p.Gln1003Glu Single submitter ⚠
- p.Gln242Arg Single submitter ⚠
- p.Gln400His Single submitter ⚠
- p.Gln485Glu Single submitter ⚠
- p.Gln485His Single submitter ⚠
- p.Gln909Arg Single submitter ⚠
- p.Glu1019Gln Single submitter ⚠
- p.Glu1022Lys Single submitter ⚠
- p.Glu171Lys Single submitter ⚠
- p.Glu472Lys Single submitter ⚠
- p.Glu855Gly Single submitter ⚠
- p.Glu881Val Single submitter ⚠
- p.Glu94Lys Single submitter ⚠
- p.Gly157Asp Single submitter ⚠
- p.Gly396Ala Single submitter ⚠
- p.Gly538Arg Single submitter ⚠
- p.Gly546Val Single submitter ⚠
- p.Gly595Arg Single submitter ⚠
- p.Gly955Ser Single submitter ⚠
- p.Gly964Asp Single submitter DAAM1-related disorder ⚠
- p.Ile107Val Single submitter ⚠
- p.Ile14Val Single submitter ⚠
- p.Ile177Thr Single submitter ⚠
- p.Ile285Phe Single submitter ⚠
- p.Ile409Val Single submitter ⚠
- p.Ile731Val Single submitter ⚠
- p.Ile840Val Single submitter ⚠
- p.Ile853Val Single submitter ⚠
- p.Leu162Phe Single submitter ⚠
- p.Leu245Pro Single submitter ⚠
- p.Leu557Pro Single submitter ⚠
- p.Leu562Phe Single submitter ⚠
- p.Leu569Ile Single submitter ⚠
- p.Lys1048Arg Single submitter ⚠
- p.Lys454Glu Single submitter ⚠
- p.Lys468Arg Single submitter ⚠
- p.Lys617Thr Single submitter ⚠
- p.Met41Val Single submitter ⚠
- p.Met47Leu Single submitter ⚠
- p.Met879Val Single submitter ⚠
- p.Met996Val Single submitter ⚠
- p.Phe334Tyr Single submitter ⚠
- p.Phe649Tyr Single submitter ⚠
- p.Phe914Leu Single submitter ⚠
- p.Pro103Arg Single submitter ⚠
- p.Pro426Ser Single submitter ⚠
- p.Pro566Gln Single submitter ⚠
- p.Pro578Gln Single submitter ⚠
- p.Pro588Leu Single submitter ⚠
- p.Pro619Arg Single submitter ⚠
- p.Pro619Thr Single submitter ⚠
- p.Pro714Ala Single submitter ⚠
- p.Pro908Gln Single submitter ⚠
- p.Pro910Ala Single submitter ⚠
- p.Pro959Ala Single submitter ⚠
- p.Ser131Cys Single submitter ⚠
- p.Ser136Arg Single submitter ⚠
- p.Ser326Pro Single submitter ⚠
- p.Ser532Leu Single submitter ⚠
- p.Ser58Gly Single submitter ⚠
- p.Ser766Leu Single submitter ⚠
- p.Ser891Thr Single submitter ⚠
- p.Ser919Asn Single submitter ⚠
- p.Thr259Ala Single submitter ⚠
- p.Tyr170Cys Single submitter ⚠
- p.Val198Ile Single submitter ⚠
- p.Val230Met Single submitter ⚠
- p.Val436Ile Single submitter ⚠
- p.Val877Ile Single submitter ⚠
- p.Val973Ala Single submitter ⚠