DAB2 — 118 ClinVar variants
All ClinVar germline DAB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →
8 Benign · 9 Likely benign · 101 Uncertain significance
Full DAB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 103
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAB2 p.Leu206Pro Uncertain significance Multiple submitters
- DAB2 p.Ala125Ser Uncertain significance Single submitter
- DAB2 p.Ala133Ser Uncertain significance Single submitter
- DAB2 p.Ala185Thr Uncertain significance Single submitter
- DAB2 p.Ala18Pro Uncertain significance Single submitter
- DAB2 p.Ala22Glu Uncertain significance Single submitter
- DAB2 p.Ala279Gly Uncertain significance Single submitter
- DAB2 p.Ala470Val Uncertain significance Single submitter
- DAB2 p.Ala577Thr Uncertain significance Single submitter
- DAB2 p.Ala668Thr Uncertain significance Single submitter
- DAB2 p.Arg267Gln Uncertain significance Single submitter
- DAB2 p.Arg661Gln Uncertain significance Single submitter
- DAB2 p.Arg762Lys Uncertain significance Single submitter
- DAB2 p.Asn226Ser Uncertain significance Single submitter
- DAB2 p.Asn291Asp Uncertain significance Single submitter
- DAB2 p.Asn352Ser Uncertain significance Single submitter
- DAB2 p.Asp700Asn Uncertain significance Single submitter
- DAB2 p.Cys263Ser Uncertain significance Single submitter
- DAB2 p.Gln212Lys Uncertain significance Single submitter
- DAB2 p.Gln345Arg Uncertain significance Single submitter
- DAB2 p.Gln469Glu Uncertain significance Single submitter
- DAB2 p.Gln659Arg Uncertain significance Single submitter
- DAB2 p.Glu695Gly Uncertain significance Single submitter
- DAB2 p.Gly139Arg Uncertain significance Single submitter
- DAB2 p.Gly217Val Uncertain significance Single submitter
- DAB2 p.Gly474Arg Uncertain significance Single submitter
- DAB2 p.Gly539Ser Uncertain significance Single submitter
- DAB2 p.Gly554Ala Uncertain significance Single submitter
- DAB2 p.Gly677Ala Uncertain significance Single submitter
- DAB2 p.Gly677Glu Uncertain significance Single submitter
- DAB2 p.Gly78Arg Uncertain significance Single submitter
- DAB2 p.His425Arg Uncertain significance Single submitter
- DAB2 p.His612Gln Uncertain significance Single submitter
- DAB2 p.Ile182Arg Uncertain significance Single submitter
- DAB2 p.Ile234Asn Uncertain significance Single submitter
- DAB2 p.Ile428Met Uncertain significance Single submitter
- DAB2 p.Ile632Met Uncertain significance Single submitter
- DAB2 p.Leu519Phe Uncertain significance Single submitter
- DAB2 p.Leu590Phe Uncertain significance Single submitter
- DAB2 p.Lys44Arg Uncertain significance Single submitter
- DAB2 p.Met73Val Uncertain significance Single submitter
- DAB2 p.Met760Leu Uncertain significance Single submitter
- DAB2 p.Pro157Ser Uncertain significance Single submitter
- DAB2 p.Pro308Thr Uncertain significance Single submitter
- DAB2 p.Pro335Ser Uncertain significance Single submitter
- DAB2 p.Pro424Arg Uncertain significance Single submitter
- DAB2 p.Ser306Leu Uncertain significance Single submitter
- DAB2 p.Ser749Pro Uncertain significance Single submitter
- DAB2 p.Thr151Ser Uncertain significance Single submitter
- DAB2 p.Thr301Pro Uncertain significance Single submitter
- DAB2 p.Thr548Ala Uncertain significance Single submitter
- DAB2 p.Tyr342His Uncertain significance Single submitter
- DAB2 p.Val128Met Uncertain significance Single submitter
- DAB2 p.Val159Phe Uncertain significance Single submitter
- DAB2 p.Val210Asp Uncertain significance Single submitter
- DAB2 p.Val381Ile Uncertain significance Single submitter
- DAB2 p.Val495Met Uncertain significance Single submitter
Predictors split 46
The independent predictors disagree with each other — read with care.
- DAB2 p.Arg296Cys Benign Multiple submitters
- DAB2 p.Gln523His Likely benign Multiple submitters
- DAB2 p.Thr505Ile Benign Multiple submitters
- DAB2 p.Val544Ile Benign Multiple submitters
- DAB2 p.Ala636Asp Uncertain significance Single submitter
- DAB2 p.Ala82Val Uncertain significance Single submitter
- DAB2 p.Arg353Trp Uncertain significance Single submitter
- DAB2 p.Arg661Trp Uncertain significance Single submitter
- DAB2 p.Arg669Gly Uncertain significance Single submitter
- DAB2 p.Asn387Lys Uncertain significance Single submitter
- DAB2 p.Asn705His Uncertain significance Single submitter
- DAB2 p.Asp164Glu Uncertain significance Single submitter
- DAB2 p.Asp224Val Uncertain significance Single submitter
- DAB2 p.Asp46Asn Uncertain significance Single submitter
- DAB2 p.Asp650Tyr Uncertain significance Single submitter
- DAB2 p.Glu141Asp Uncertain significance Single submitter
- DAB2 p.Gly152Arg Uncertain significance Single submitter
- DAB2 p.Gly334Trp Uncertain significance Single submitter
- DAB2 p.Gly380Arg Uncertain significance Single submitter
- DAB2 p.Gly411Asp Uncertain significance Single submitter
- DAB2 p.Gly496Glu Uncertain significance Single submitter
- DAB2 p.Gly535Arg Uncertain significance Single submitter
- DAB2 p.Gly554Asp Uncertain significance Single submitter
- DAB2 p.Leu708Trp Uncertain significance Single submitter
- DAB2 p.Lys413Met Uncertain significance Single submitter
- DAB2 p.Lys649Gln Uncertain significance Single submitter
- DAB2 p.Pro20Leu Uncertain significance Single submitter
- DAB2 p.Pro223Leu Uncertain significance Single submitter
- DAB2 p.Pro292Arg Uncertain significance Single submitter
- DAB2 p.Pro330Leu Uncertain significance Single submitter
- DAB2 p.Pro529Leu Uncertain significance Single submitter
- DAB2 p.Pro543Ser Uncertain significance Single submitter
- DAB2 p.Pro608Leu Uncertain significance Single submitter
- DAB2 p.Pro620Ser Uncertain significance Single submitter
- DAB2 p.Pro764Leu Uncertain significance Single submitter
- DAB2 p.Ser436Cys Uncertain significance Single submitter
- DAB2 p.Ser559Leu Uncertain significance Single submitter
- DAB2 p.Ser605Tyr Uncertain significance Single submitter
- DAB2 p.Ser680Cys Uncertain significance Single submitter
- DAB2 p.Thr221Ala Uncertain significance Single submitter
- DAB2 p.Thr289Ile Uncertain significance Single submitter
- DAB2 p.Thr437Ile Uncertain significance Single submitter
- DAB2 p.Tyr170Cys Uncertain significance Single submitter
- DAB2 p.Val463Ile Uncertain significance Single submitter
- DAB2 p.Val571Ile Uncertain significance Single submitter
- DAB2 p.Val666Gly Uncertain significance Single submitter
All DAB2 variants
Benign 8
- c.571-9T>A Multiple submitters
- p.Arg296= Multiple submitters
- p.Arg296Cys Multiple submitters ⚠
- p.Asn226= Multiple submitters
- p.Ser227= Multiple submitters
- p.Thr505Ile Multiple submitters ⚠
- p.Thr587Ala Multiple submitters
- p.Val544Ile Multiple submitters ⚠
Likely benign 9
- p.Gln523His Multiple submitters ⚠
- p.Pro529= Multiple submitters
- c.570+7T>C Single submitter
- p.Ala528Val Single submitter
- p.Arg762= Single submitter
- p.Gly192= Single submitter
- p.His89= Single submitter
- p.Ile430Val Single submitter
- p.Ser324Leu Single submitter
Uncertain significance 101
- p.Leu206Pro Multiple submitters ⚠
- p.Ala125Ser Single submitter ⚠
- p.Ala133Ser Single submitter ⚠
- p.Ala185Thr Single submitter ⚠
- p.Ala18Pro Single submitter ⚠
- p.Ala22Glu Single submitter ⚠
- p.Ala279Gly Single submitter ⚠
- p.Ala470Val Single submitter ⚠
- p.Ala577Thr Single submitter ⚠
- p.Ala636Asp Single submitter ⚠
- p.Ala668Thr Single submitter ⚠
- p.Ala82Val Single submitter ⚠
- p.Arg267Gln Single submitter ⚠
- p.Arg353Trp Single submitter ⚠
- p.Arg661Gln Single submitter ⚠
- p.Arg661Trp Single submitter ⚠
- p.Arg669Gly Single submitter ⚠
- p.Arg762Lys Single submitter ⚠
- p.Asn226Ser Single submitter ⚠
- p.Asn291Asp Single submitter ⚠
- p.Asn352Ser Single submitter ⚠
- p.Asn387Lys Single submitter ⚠
- p.Asn705His Single submitter ⚠
- p.Asp164Glu Single submitter ⚠
- p.Asp224Val Single submitter ⚠
- p.Asp46Asn Single submitter ⚠
- p.Asp650Tyr Single submitter ⚠
- p.Asp700Asn Single submitter ⚠
- p.Cys263Ser Single submitter ⚠
- p.Gln212Lys Single submitter ⚠
- p.Gln345Arg Single submitter ⚠
- p.Gln469Glu Single submitter ⚠
- p.Gln659Arg Single submitter ⚠
- p.Glu141Asp Single submitter ⚠
- p.Glu695Gly Single submitter ⚠
- p.Gly139Arg Single submitter ⚠
- p.Gly152Arg Single submitter ⚠
- p.Gly217Val Single submitter ⚠
- p.Gly334Trp Single submitter ⚠
- p.Gly380Arg Single submitter ⚠
- p.Gly411Asp Single submitter ⚠
- p.Gly474Arg Single submitter ⚠
- p.Gly496Glu Single submitter ⚠
- p.Gly535Arg Single submitter ⚠
- p.Gly539Ser Single submitter ⚠
- p.Gly554Ala Single submitter ⚠
- p.Gly554Asp Single submitter ⚠
- p.Gly677Ala Single submitter ⚠
- p.Gly677Glu Single submitter ⚠
- p.Gly78Arg Single submitter ⚠
- p.His425Arg Single submitter ⚠
- p.His612Gln Single submitter ⚠
- p.Ile182Arg Single submitter ⚠
- p.Ile234Asn Single submitter ⚠
- p.Ile428Met Single submitter ⚠
- p.Ile632Met Single submitter ⚠
- p.Leu519Phe Single submitter ⚠
- p.Leu590Phe Single submitter ⚠
- p.Leu708Trp Single submitter ⚠
- p.Lys180Ter Single submitter teratocarcinoma
- p.Lys413Met Single submitter ⚠
- p.Lys44Arg Single submitter ⚠
- p.Lys649Gln Single submitter ⚠
- p.Met73Val Single submitter ⚠
- p.Met760Leu Single submitter ⚠
- p.Phe398fs Single submitter
- p.Pro157Ser Single submitter ⚠
- p.Pro20Leu Single submitter ⚠
- p.Pro223Leu Single submitter ⚠
- p.Pro292Arg Single submitter ⚠
- p.Pro308Thr Single submitter ⚠
- p.Pro330Leu Single submitter ⚠
- p.Pro335Ser Single submitter ⚠
- p.Pro424Arg Single submitter ⚠
- p.Pro529Leu Single submitter ⚠
- p.Pro543Ser Single submitter ⚠
- p.Pro608Leu Single submitter ⚠
- p.Pro620Ser Single submitter ⚠
- p.Pro764Leu Single submitter ⚠
- p.Ser306Leu Single submitter ⚠
- p.Ser436Cys Single submitter ⚠
- p.Ser559Leu Single submitter ⚠
- p.Ser605Tyr Single submitter ⚠
- p.Ser680Cys Single submitter ⚠
- p.Ser749Pro Single submitter ⚠
- p.Thr151Ser Single submitter ⚠
- p.Thr221Ala Single submitter ⚠
- p.Thr289Ile Single submitter ⚠
- p.Thr301Pro Single submitter ⚠
- p.Thr437Ile Single submitter ⚠
- p.Thr548Ala Single submitter ⚠
- p.Tyr170Cys Single submitter ⚠
- p.Tyr342His Single submitter ⚠
- p.Val128Met Single submitter ⚠
- p.Val159Phe Single submitter ⚠
- p.Val210Asp Single submitter ⚠
- p.Val381Ile Single submitter ⚠
- p.Val463Ile Single submitter ⚠
- p.Val495Met Single submitter ⚠
- p.Val571Ile Single submitter ⚠
- p.Val666Gly Single submitter ⚠