DACH1 — 80 ClinVar variants
All ClinVar germline DACH1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
1 Conflicting · 1 Benign · 1 Benign/Likely benign · 3 Likely benign · 74 Uncertain significance
Full DACH1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DACH1 p.Ala109Val Uncertain significance Single submitter
- DACH1 p.Ala36Val Uncertain significance Single submitter
- DACH1 p.Ala533Thr Uncertain significance Single submitter
- DACH1 p.Arg629Ser Uncertain significance Single submitter
- DACH1 p.Arg650Leu Uncertain significance Single submitter
- DACH1 p.Asn113Thr Uncertain significance Single submitter
- DACH1 p.Gln574Lys Uncertain significance Single submitter
- DACH1 p.Gln660Arg Uncertain significance Single submitter
- DACH1 p.Glu204Lys Uncertain significance Single submitter
- DACH1 p.Glu504Asp Uncertain significance Single submitter
- DACH1 p.Gly509Ser Uncertain significance Single submitter
- DACH1 p.Ile20Val Uncertain significance Single submitter
- DACH1 p.Ile338Val Uncertain significance Single submitter
- DACH1 p.Ile44Val Uncertain significance Single submitter
- DACH1 p.Ile521Thr Uncertain significance Single submitter
- DACH1 p.Leu108Val Uncertain significance Single submitter
- DACH1 p.Leu222Ser Uncertain significance Single submitter
- DACH1 p.Leu598Gln Uncertain significance Single submitter
- DACH1 p.Met190Thr Uncertain significance Single submitter
- DACH1 p.Met371Thr Uncertain significance Single submitter
- DACH1 p.Met519Leu Uncertain significance Single submitter
- DACH1 p.Phe602Cys Uncertain significance Single submitter
- DACH1 p.Pro176Gln Uncertain significance Single submitter
- DACH1 p.Pro306Leu Uncertain significance Single submitter
- DACH1 p.Pro320Ser Uncertain significance Single submitter
- DACH1 p.Pro47Leu Uncertain significance Single submitter
- DACH1 p.Pro548Leu Uncertain significance Single submitter
- DACH1 p.Thr11Ser Uncertain significance Single submitter
- DACH1 p.Thr175Ile Uncertain significance Single submitter
- DACH1 p.Thr703Pro Uncertain significance Single submitter
- DACH1 p.Thr703Ser Uncertain significance Single submitter
- DACH1 p.Val296Ile Uncertain significance Single submitter
- DACH1 p.Val498Ile Uncertain significance Single submitter
- DACH1 p.Cys188Tyr Uncertain significance No assertion criteria
Predictors split 39
The independent predictors disagree with each other — read with care.
- DACH1 p.Ala36Glu Uncertain significance Single submitter
- DACH1 p.Ala418Thr Uncertain significance Single submitter
- DACH1 p.Ala586Thr Uncertain significance Single submitter
- DACH1 p.Ala64Val Uncertain significance Single submitter
- DACH1 p.Ala661Glu Uncertain significance Single submitter
- DACH1 p.Ala68Asp Uncertain significance Single submitter
- DACH1 p.Arg435His Uncertain significance Single submitter
- DACH1 p.Arg470Gln Uncertain significance Single submitter
- DACH1 p.Asn359Lys Uncertain significance Single submitter
- DACH1 p.Asn91Lys Uncertain significance Single submitter
- DACH1 p.Gly116Ala Uncertain significance Single submitter
- DACH1 p.Gly117Cys Uncertain significance Single submitter
- DACH1 p.Gly118Asp Uncertain significance Single submitter
- DACH1 p.Gly118Cys Uncertain significance Single submitter
- DACH1 p.Gly165Cys Uncertain significance Single submitter
- DACH1 p.Gly696Glu Uncertain significance Single submitter
- DACH1 p.Gly76Cys Uncertain significance Single submitter
- DACH1 p.Gly78Asp Uncertain significance Single submitter
- DACH1 p.Gly86Ser Uncertain significance Single submitter
- DACH1 p.Gly97Ser Uncertain significance Single submitter
- DACH1 p.Ile566Met Uncertain significance Single submitter
- DACH1 p.Ile566Val Uncertain significance Single submitter
- DACH1 p.Ile625Val Uncertain significance Single submitter
- DACH1 p.Pro16Arg Uncertain significance Single submitter
- DACH1 p.Pro57Arg Uncertain significance Single submitter
- DACH1 p.Ser140Arg Uncertain significance Single submitter
- DACH1 p.Ser147Ile Uncertain significance Single submitter
- DACH1 p.Ser153Arg Uncertain significance Single submitter
- DACH1 p.Ser295Cys Uncertain significance Single submitter
- DACH1 p.Ser473Arg Uncertain significance Single submitter
- DACH1 p.Ser536Asn Uncertain significance Single submitter
- DACH1 p.Ser82Asn Uncertain significance Single submitter
- DACH1 p.Ser89Arg Uncertain significance Single submitter
- DACH1 p.Thr648Lys Uncertain significance Single submitter
- DACH1 p.Tyr173Cys Uncertain significance Single submitter
- DACH1 p.Tyr706Cys Uncertain significance Single submitter
- DACH1 p.Val436Phe Uncertain significance Single submitter
- DACH1 p.Val464Met Uncertain significance Single submitter
- DACH1 p.Val704Ala Uncertain significance Single submitter
All DACH1 variants
Conflicting classifications of pathogenicity 1
- c.1722+6C>T Single submitter
Benign 1
- p.Val375= Multiple submitters
Benign/Likely benign 1
- p.Gly79_Gly81del Multiple submitters
Uncertain significance 74
- p.= Single submitter
- p.Ala109Val Single submitter ⚠
- p.Ala36Glu Single submitter ⚠
- p.Ala36Val Single submitter ⚠
- p.Ala418Thr Single submitter ⚠
- p.Ala533Thr Single submitter ⚠
- p.Ala586Thr Single submitter ⚠
- p.Ala64Val Single submitter ⚠
- p.Ala661Glu Single submitter ⚠
- p.Ala68Asp Single submitter ⚠
- p.Arg435His Single submitter ⚠
- p.Arg470Gln Single submitter ⚠
- p.Arg629Ser Single submitter ⚠
- p.Arg650Leu Single submitter ⚠
- p.Asn113Thr Single submitter ⚠
- p.Asn359Lys Single submitter ⚠
- p.Asn91Lys Single submitter ⚠
- p.Gln574Lys Single submitter ⚠
- p.Gln660Arg Single submitter ⚠
- p.Glu204Lys Single submitter ⚠
- p.Glu504Asp Single submitter ⚠
- p.Gly116Ala Single submitter ⚠
- p.Gly117Cys Single submitter ⚠
- p.Gly118Asp Single submitter ⚠
- p.Gly118Cys Single submitter ⚠
- p.Gly165Cys Single submitter ⚠
- p.Gly509Ser Single submitter ⚠
- p.Gly696Glu Single submitter ⚠
- p.Gly76Cys Single submitter ⚠
- p.Gly78Asp Single submitter ⚠
- p.Gly86Ser Single submitter ⚠
- p.Gly97Ser Single submitter ⚠
- p.Ile20Val Single submitter ⚠
- p.Ile338Val Single submitter ⚠
- p.Ile44Val Single submitter ⚠
- p.Ile521Thr Single submitter ⚠
- p.Ile566Met Single submitter ⚠
- p.Ile566Val Single submitter ⚠
- p.Ile625Val Single submitter ⚠
- p.Leu108Val Single submitter ⚠
- p.Leu222Ser Single submitter ⚠
- p.Leu598Gln Single submitter ⚠
- p.Met190Thr Single submitter ⚠
- p.Met371Thr Single submitter ⚠
- p.Met519Leu Single submitter ⚠
- p.Phe602Cys Single submitter ⚠
- p.Pro16Arg Single submitter ⚠
- p.Pro176Gln Single submitter ⚠
- p.Pro306Leu Single submitter ⚠
- p.Pro320Ser Single submitter ⚠
- p.Pro47Leu Single submitter ⚠
- p.Pro548Leu Single submitter ⚠
- p.Pro57Arg Single submitter ⚠
- p.Ser140Arg Single submitter ⚠
- p.Ser147Ile Single submitter ⚠
- p.Ser153Arg Single submitter ⚠
- p.Ser295Cys Single submitter ⚠
- p.Ser473Arg Single submitter ⚠
- p.Ser536Asn Single submitter ⚠
- p.Ser82Asn Single submitter ⚠
- p.Ser89Arg Single submitter ⚠
- p.Thr11Ser Single submitter ⚠
- p.Thr175Ile Single submitter ⚠
- p.Thr648Lys Single submitter ⚠
- p.Thr703Pro Single submitter ⚠
- p.Thr703Ser Single submitter ⚠
- p.Tyr173Cys Single submitter ⚠
- p.Tyr706Cys Single submitter ⚠
- p.Val296Ile Single submitter ⚠
- p.Val436Phe Single submitter ⚠
- p.Val464Met Single submitter ⚠
- p.Val498Ile Single submitter ⚠
- p.Val704Ala Single submitter ⚠
- p.Cys188Tyr No assertion criteria ⚠