DAD1 — 21 ClinVar variants
All ClinVar germline DAD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
9 Benign · 12 Uncertain significance
Full DAD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 7
The independent predictors disagree with each other — read with care.
- DAD1 p.Ala93Gly Uncertain significance Single submitter
- DAD1 p.Gln22Arg Uncertain significance Single submitter
- DAD1 p.Leu46Arg Uncertain significance Single submitter
- DAD1 p.Ser10Leu Uncertain significance Single submitter
- DAD1 p.Ser4Trp Uncertain significance Single submitter
- DAD1 p.Ser7Cys Uncertain significance Single submitter
- DAD1 p.Val8Ala Uncertain significance Single submitter
All DAD1 variants
Benign 9
- c.212-128T>C Multiple submitters
- c.*44+172T>C Multiple submitters
- c.*44+72A>T Multiple submitters
- p.Ter114= Multiple submitters
- c.211+186C>G Single submitter
- c.212-210T>C Single submitter
- c.212-308del Single submitter
- c.*44+266A>G Single submitter
- c.*44+278del Single submitter
Uncertain significance 12
- p.Ala93Asp Single submitter ⚠
- p.Ala93Gly Single submitter ⚠
- p.Asn54Lys Single submitter ⚠
- p.Cys45Arg Single submitter ⚠
- p.Gln22Arg Single submitter ⚠
- p.Ile34Thr Single submitter ⚠
- p.Ile68Val Single submitter ⚠
- p.Leu46Arg Single submitter ⚠
- p.Ser10Leu Single submitter ⚠
- p.Ser4Trp Single submitter ⚠
- p.Ser7Cys Single submitter ⚠
- p.Val8Ala Single submitter ⚠