DAGLB — 177 ClinVar variants

All ClinVar germline DAGLB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 158 flagged for review →

6 Benign · 2 Benign/Likely benign · 11 Likely benign · 158 Uncertain significance

Full DAGLB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 158

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 100

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 58

The independent predictors disagree with each other — read with care.

All DAGLB variants

Benign 6

c.1570-9C>T Single submitter
p.Ala237= Single submitter
p.Ala656Thr Single submitter
p.Ile596Thr Single submitter
p.Leu451= Single submitter
p.Val659Ile Single submitter

Benign/Likely benign 2

p.Asn131= Multiple submitters
p.Gly632= Multiple submitters

Likely benign 11

p.Arg568His Single submitter
p.Asn541Asp Single submitter
p.Cys278= Single submitter
p.His529= Single submitter
p.Ile204Val Single submitter
p.Ile643Val Single submitter
p.Leu199Phe Single submitter
p.Leu239= Single submitter
p.Lys628Arg Single submitter
p.Ser668Asn Single submitter
p.Ser74Leu Single submitter

Uncertain significance 158

p.Asp247Glu Multiple submitters ⚠
p.Ala116Thr Single submitter ⚠
p.Ala12Thr Single submitter ⚠
p.Ala145Thr Single submitter ⚠
p.Ala145Val Single submitter ⚠
p.Ala146Gly Single submitter ⚠
p.Ala163Asp Single submitter ⚠
p.Ala213Val Single submitter ⚠
p.Ala256Val Single submitter ⚠
p.Ala361Val Single submitter ⚠
p.Ala388Thr Single submitter ⚠
p.Ala450Thr Single submitter ⚠
p.Ala467Thr Single submitter ⚠
p.Ala50Gly Single submitter ⚠
p.Ala53Ser Single submitter ⚠
p.Ala604Asp Single submitter ⚠
p.Ala618Gly Single submitter ⚠
p.Ala618Thr Single submitter ⚠
p.Ala624Val Single submitter ⚠
p.Ala657Asp Single submitter ⚠
p.Arg101Cys Single submitter ⚠
p.Arg211Gln Single submitter ⚠
p.Arg29Pro Single submitter ⚠
p.Arg312Gly Single submitter ⚠
p.Arg342Gly Single submitter ⚠
p.Arg402His Single submitter ⚠
p.Arg436Gln Single submitter ⚠
p.Arg436Trp Single submitter ⚠
p.Arg44Lys Single submitter ⚠
p.Arg472Gln Single submitter ⚠
p.Arg472Trp Single submitter ⚠
p.Arg499Ser Single submitter ⚠
p.Arg514Gln Single submitter ⚠
p.Arg514Gly Single submitter ⚠
p.Arg568Cys Single submitter ⚠
p.Arg655Thr Single submitter ⚠
p.Asn131Tyr Single submitter ⚠
p.Asn183His Single submitter ⚠
p.Asn277Lys Single submitter ⚠
p.Asn277Ser Single submitter ⚠
p.Asn327Asp Single submitter ⚠
p.Asn541Lys Single submitter ⚠
p.Asp126Asn Single submitter ⚠
p.Asp324Asn Single submitter ⚠
p.Asp324Tyr Single submitter ⚠
p.Asp381Gly Single submitter ⚠
p.Asp394Asn Single submitter ⚠
p.Asp48Glu Single submitter ⚠
p.Asp495Tyr Single submitter ⚠
p.Asp507Tyr Single submitter ⚠
p.Asp551Asn Single submitter ⚠
p.Cys125Trp Single submitter ⚠
p.Cys202Tyr Single submitter ⚠
p.Cys610Tyr Single submitter ⚠
p.Cys658Ser Single submitter ⚠
p.Cys71Phe Single submitter ⚠
p.Cys71Tyr Single submitter ⚠
p.Gln124His Single submitter ⚠
p.Gln257His Single submitter ⚠
p.Gln400Leu Single submitter ⚠
p.Gln557Arg Single submitter ⚠
p.Glu194Gly Single submitter ⚠
p.Glu254Lys Single submitter ⚠
p.Glu274Asp Single submitter ⚠
p.Glu534Lys Single submitter ⚠
p.Gly132Ser Single submitter ⚠
p.Gly169Arg Single submitter ⚠
p.Gly331Asp Single submitter ⚠
p.Gly331Ser Single submitter ⚠
p.Gly338Ala Single submitter ⚠
p.Gly423Arg Single submitter ⚠
p.Gly446Asp Single submitter ⚠
p.Gly45Arg Single submitter ⚠
p.Gly473Ala Single submitter ⚠
p.Gly530Ser Single submitter ⚠
p.Gly549Ala Single submitter ⚠
p.Gly549Arg Single submitter ⚠
p.Gly550Ala Single submitter ⚠
p.Gly550Ser Single submitter ⚠
p.His243Arg Single submitter ⚠
p.Ile151Thr Single submitter ⚠
p.Ile153Thr Single submitter ⚠
p.Ile204Thr Single submitter ⚠
p.Ile345Met Single submitter ⚠
p.Ile408Val Single submitter ⚠
p.Ile439Thr Single submitter ⚠
p.Ile487Met Single submitter ⚠
p.Ile512Ser Single submitter ⚠
p.Ile76Asn Single submitter ⚠
p.Leu200Phe Single submitter ⚠
p.Leu220Arg Single submitter ⚠
p.Leu334Met Single submitter ⚠
p.Leu362Pro Single submitter ⚠
p.Leu386Met Single submitter ⚠
p.Leu39Val Single submitter ⚠
p.Leu403Pro Single submitter ⚠
p.Leu560Val Single submitter ⚠
p.Leu59Phe Single submitter ⚠
p.Leu6Val Single submitter ⚠
p.Leu97Val Single submitter ⚠
p.Lys186Gln Single submitter ⚠
p.Lys366Glu Single submitter ⚠
p.Met109Val Single submitter ⚠
p.Met4Ile Single submitter ⚠
p.Met63Thr Single submitter ⚠
p.Met63Val Single submitter ⚠
p.Met645Ile Single submitter ⚠
p.Met94Leu Single submitter ⚠
p.Phe349Leu Single submitter ⚠
p.Phe358Cys Single submitter ⚠
p.Pro107Ser Single submitter ⚠
p.Pro157Ala Single submitter ⚠
p.Pro157Thr Single submitter ⚠
p.Pro164Ser Single submitter ⚠
p.Pro299Arg Single submitter ⚠
p.Pro433Ser Single submitter ⚠
p.Pro461Leu Single submitter ⚠
p.Pro633Ala Single submitter ⚠
p.Pro633Leu Single submitter ⚠
p.Ser178Pro Single submitter ⚠
p.Ser215Leu Single submitter ⚠
p.Ser430Asn Single submitter ⚠
p.Ser605Leu Single submitter ⚠
p.Ser627Cys Single submitter ⚠
p.Thr136Asn Single submitter ⚠
p.Thr187Ala Single submitter ⚠
p.Thr187Lys Single submitter ⚠
p.Thr228Ala Single submitter ⚠
p.Thr301Met Single submitter ⚠
p.Thr316Ala Single submitter ⚠
p.Thr384Arg Single submitter ⚠
p.Thr545Ala Single submitter ⚠
p.Thr545Lys Single submitter ⚠
p.Thr556Ile Single submitter ⚠
p.Thr567Met Single submitter ⚠
p.Trp569Cys Single submitter ⚠
p.Tyr318Cys Single submitter ⚠
p.Tyr40Cys Single submitter ⚠
p.Tyr616Cys Single submitter ⚠
p.Val110Leu Single submitter ⚠
p.Val129Gly Single submitter ⚠
p.Val130Leu Single submitter ⚠
p.Val192Leu Single submitter ⚠
p.Val192Met Single submitter ⚠
p.Val212Ala Single submitter ⚠
p.Val212Leu Single submitter ⚠
p.Val231Ala Single submitter ⚠
p.Val28Met Single submitter ⚠
p.Val392Leu Single submitter ⚠
p.Val395Met Single submitter ⚠
p.Val399Gly Single submitter ⚠
p.Val415Ile Single submitter ⚠
p.Val488Met Single submitter ⚠
p.Val491Ile Single submitter ⚠
p.Val496Gly Single submitter ⚠
p.Val651Met Single submitter ⚠
p.Val666Ile Single submitter ⚠
p.Val671Met Single submitter ⚠